Eli Peled
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View article: Effect of bone marrow blood versus peripheral blood on the hemostatic balance of osteoblasts and endothelial cells
Effect of bone marrow blood versus peripheral blood on the hemostatic balance of osteoblasts and endothelial cells Open
Bone and bone-marrow (BM) have the same blood supply and thus may be considered as one organ. We previously demonstrated that the microcirculation hemostatic balance that includes heparanase, tissue factor (TF), TF pathway inhibitor (TFPI)…
View article: Revisiting Antibiotic-Impregnated Cement Spacer for Diabetic Osteomyelitis of the Foot
Revisiting Antibiotic-Impregnated Cement Spacer for Diabetic Osteomyelitis of the Foot Open
Introduction: Despite the rising global awareness and improvement of socioeconomic and living standards, the prevalence of diabetic osteomyelitis (DOM) and its complications has been increasing rapidly. This study aims to investigate the l…
View article: Steroids and Malignancy Increase Local Heparanase and Decrease Markers of Osteoblast Activity in Bone Tissue Microcirculation
Steroids and Malignancy Increase Local Heparanase and Decrease Markers of Osteoblast Activity in Bone Tissue Microcirculation Open
Bone metastasis and steroids are known to activate the coagulation system and induce osteoporosis, pathological bone fractures, and bone pain. Heparanase is a protein known to enhance the hemostatic system and to promote angiogenesis, meta…
View article: Development of a local controlled release system for therapeutic proteins in the treatment of skeletal muscle injuries and diseases
Development of a local controlled release system for therapeutic proteins in the treatment of skeletal muscle injuries and diseases Open
The present study aims to develop and characterize a controlled-release delivery system for protein therapeutics in skeletal muscle regeneration following an acute injury. The therapeutic protein, a membrane-GPI anchored protein called Cri…
View article: A combined cell and growth factor delivery for the repair of a critical size tibia defect using biodegradable hydrogel implants
A combined cell and growth factor delivery for the repair of a critical size tibia defect using biodegradable hydrogel implants Open
The ability to repair critical-sized long-bone injuries using growth factor and cell delivery was investigated using hydrogel biomaterials. Physiological doses of the recombinant human bone morphogenic protein-2 (rhBMP2) were delivered in …
View article: Interobserver and intraobserver agreement for Letournel acetabular fracture classification system using 3-dimensional printed solid models
Interobserver and intraobserver agreement for Letournel acetabular fracture classification system using 3-dimensional printed solid models Open
The Judet-Letournel classification demonstrated only moderate rates of agreement. The use of 3-D printed models increased the inter-observer agreement rates with respect to fracture classification, but decreased it with respect to the pref…
View article: Heparan sulfate chains contribute to the anticoagulant milieu in malignant pleural effusion
Heparan sulfate chains contribute to the anticoagulant milieu in malignant pleural effusion Open
Background While malignant pleural effusion (MPE) is a common and significant cause of morbidity in patients with cancer, current treatment options are limited. Human heparanase, involved in angiogenesis and metastasis, cleaves heparan sul…
View article: Depletion of B cells rejuvenates the peripheral B‐cell compartment but is insufficient to restore immune competence in aging
Depletion of B cells rejuvenates the peripheral B‐cell compartment but is insufficient to restore immune competence in aging Open
Aging is associated with increasing prevalence and severity of infections caused by a decline in bone marrow (BM) lymphopoiesis and reduced B‐cell repertoire diversity. The current study proposes a strategy to enhance immune responsiveness…
View article: Positive outcomes following gait therapy intervention for hip osteoarthritis: A longitudinal study
Positive outcomes following gait therapy intervention for hip osteoarthritis: A longitudinal study Open
Footwear‐generated biomechanical manipulation of lower‐limb joints was shown to beneficially impact gait and quality of life in knee osteoarthritis patients, but has not been tested in hip osteoarthritis patients. We examined a customized …
View article: Salvage of Diabetic Foot Osteomyelitis With Antibiotic Impregnated Cement Spacer- Long Term Follow Up
Salvage of Diabetic Foot Osteomyelitis With Antibiotic Impregnated Cement Spacer- Long Term Follow Up Open
Category: Diabetes Introduction/Purpose: Diabetic foot infections (DFI) with osteomyelitis often requires minor amputation as a mean to achieve adequate debridement and infection eradication. In the past years we have developed and used a …
View article: Reduction of hip joint reaction force via medio‐lateral foot center of pressure manipulation in bilateral hip osteoarthritis patients
Reduction of hip joint reaction force via medio‐lateral foot center of pressure manipulation in bilateral hip osteoarthritis patients Open
Loading/excessive loading of the hip joint has been linked to onset and progression of hip osteoarthritis. Footwear‐generated biomechanical manipulation in the frontal plane has been previously shown in a cohort of healthy subjects to caus…