Explanipedia

Addressing misleading medical information on social media: a scoping review of current interventions Open

Emma Grundtvig Gram, Ray Moynihan, Tessa Copp, Patti Shih, Loai Albarqouni , et al. · 2025

Background Misleading information about medical products on social media may cause overuse. Objectives Explore interventions targeting the problem of misleading medical information and marketing on social media, with a focus on preventing …

Improving the Reporting on Health Equity in Observational Research (STROBE-Equity) Open

Omar Dewidar, Larissa Shamseer, G. J. Meléndez‐Torres, Elie A. Akl, Jacqueline Ramke , et al. · 2025

Importance Observational studies can provide valuable insights to inform decisions on health equity. Existing guidelines for reporting such studies, such as the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) …

Improving the reporting on health equity in observational research (STROBE-Equity): extension checklist and elaboration Open

Omar Dewidar, Larissa Shamseer, G. J. Meléndez‐Torres, Elie A. Akl, Jacqueline Ramke , et al. · 2025

Capturing the influx of living systematic reviews: a systematic methodological survey Open

Clareece R. Nevill, Aoife O’Mahony, Hasan Tahir, Will Robinson, Urvi Modha , et al. · 2025

Every year, a huge amount of health-related research is published and it is difficult for busy doctors and health care workers to keep up to date with all of the new evidence. To help with this, the research can be summarized by carrying o…

Minimal important differences of measurement instruments used in rheumatoid arthritis: a scoping review Open

Sally Yaacoub, Anas El Zouhbi, Michella Abi Zeid Daou, Vicky Nahra, Abir Mokbel , et al. · 2025

We identified the MID estimates for a substantive number of measurement instruments used in rheumatoid arthritis. There was considerable variability in the findings for the same instrument within and across studies.

Ultrasound-guided arterial cannulation in the paediatric population: a Cochrane review Open

Christian K Raphael, Nour A El Hage Chehade, Joanne Khabsa, Elie A. Akl, Marie Aouad-Maroun , et al. · 2025

Introducing a series of reviews assessing engagement in evidence syntheses Open

Jennifer Petkovic, Joanne Khabsa, Lyubov Lytvyn, Alex Todhunter‐Brown, Olivia Magwood , et al. · 2025

An international guideline training and certification programme Open

Holger J. Schünemann, Patrick Okwen, Elie A. Akl, Paul Chrisp, Philipp Dahm , et al. · 2025

Enhancing health equity considerations in guidelines: health equity extension of the GIN-McMaster Guideline Development Checklist Open

Omar Dewidar, Shahab Sayfi, Jordi Pardo Pardo, Vivian Welch, Grace C. Wright , et al. · 2025

This project was partially funded by Public Health Agency of Canada. The funder was not involved in the conceptualization or design or the conduct of the project.

Development of ROBUST-RCT: Risk Of Bias instrument for Use in SysTematic reviews-for Randomised Controlled Trials Open

Ying Wang, Sheri A. Keitz, Matthias Briel, Paul Glasziou, Romina Brignardello-Petersen , et al. · 2025

GRADE guidance 40: The GRADE evidence-to-decision framework for environmental and occupational health Open

Emily Senerth, Paul Whaley, Elie A. Akl, Brandy Beverly, Pablo Alonso‐Coello , et al. · 2025

Policymakers, regulators, and other stakeholders may use this GRADE EtD framework to approach decision-making about environmental and occupational exposures and interventions.

Update to the PRISMA guidelines for network meta-analyses and scoping reviews and development of guidelines for rapid reviews: a scoping review protocol Open

Areti Angeliki Veroniki, Brian Hutton, Adrienne Stevens, Joanne E. McKenzie, Matthew J. Page , et al. · 2025

Objective: The objective of this scoping review is to develop a list of items for potential inclusion in the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) reporting guidelines for network meta-analysis (NMA), …

Seven Principles for Integrating Health Equity Considerations in the Practice Guideline Enterprise Open

Omar Dewidar, Andrea Darzi, Shahab Sayfi, Jordi Pardo Pardo, Vivian Welch , et al. · 2025

Reliability And Usability of the Right-Coi&F Reporting Guideline: User Survey and Test of the Checklist Open

Yangqin Xun, Janne Estill, D.A. Sychev Sychev, I V Poddubnaya, Elena Yudina , et al. · 2025

Development of a framework to structure decision-making in environmental and occupational health: A systematic review and Delphi study Open

Emily Senerth, Paul Whaley, Elie A. Akl, Brandy Beverly, Pablo Alonso‐Coello , et al. · 2024

Findings of this mixed-methods study comprise a foundation for a GRADE EtD that is applicable for use in EOH decision-making, with implications for approaches to regulation of environmental and occupational exposures and the formulation of…

Using bibliometrics to detect questionable authorship and affiliation practices and their impact on global research metrics: A case study of 14 universities Open

Lokman I. Meho, Elie A. Akl · 2024

From 2019 to 2023, a subset of 80 highly published universities demonstrated research output increases exceeding 100%, compared to the global average of 20%. Among these, 14 institutions showed significant declines in first authorship rate…

Defining decision thresholds for judgments on health benefits and harms using the grading of recommendations assessment, development, and evaluation (GRADE) evidence to decision (EtD) frameworks: a randomized methodological study (GRADE-THRESHOLD) Open

Gian Paolo Morgano, Wojtek Wiercioch, Daniele Piovani, Ignacio Neumann, Robby Nieuwlaat , et al. · 2024

Decision thresholds (DTs) help with determining if effects of interventions should be considered absent, small, moderate or large. In this study we derived an overarching approach for these thresholds across conditions and outcomes. The re…

Guidance for engagement in health guideline development: A scoping review Open

Jennifer Petkovic, Alison Riddle, Lyubov Lytvyn, Joanne Khabsa, Elie A. Akl , et al. · 2024

Background Health guideline developers engage with interested people and groups to ensure that guidelines and their recommendations are relevant and useful to those who will be affected by them. These ‘interest‐holders’ include patients, p…

Extension of the PRISMA 2020 statement for living systematic reviews (PRISMA-LSR): checklist and explanation Open

Elie A. Akl, Joanne Khabsa, Claire Iannizzi, Vanessa Piechotta, Lara A Kahale , et al. · 2024

Publications of living systematic reviews (LSRs) are increasing rapidly. Guidance facilitating transparent, complete, and accurate reporting of LSRs is needed. This paper reports the development of an extension of the Preferred Reporting I…

“Interest‐holders”: A new term to replace “stakeholders” in the context of health research and policy Open

Elie A. Akl, Joanne Khabsa, Jennifer Petkovic, Olivia Magwood, Lyubov Lytvyn , et al. · 2024

Background Given the colonial connotations of the term “stakeholder”, its continued use may be perceived as disrespectful to Indigenous Peoples. While several groups have introduced alternative terms, each has its own limitations. The obje…

American Society of Hematology living guidelines on use of anticoagulation for thromboprophylaxis for patients with COVID-19: executive summary Open

Deborah Siegal, Eric Tseng, Holger J. Schünemann, Pantep Angchaisuksiri, Adam Cuker , et al. · 2024

Background COVID-19–related critical and acute illness is associated with an increased risk of venous thromboembolism (VTE). These evidence-based recommendations of the American Society of Hematology (ASH) are intended to support patients,…

Protocol: Assessing the impact of interest‐holder engagement on guideline development: A systematic review Open

Lyubov Lytvyn, Jennifer Petkovic, Joanne Khabsa, Olivia Magwood, Pauline Campbell , et al. · 2024

This is the protocol for a Campbell systematic review. The objectives are as follows. The objective of this review is to identify and synthesize empirical research on the impacts of interest‐holder engagement on the guideline development p…

GRADE guidance 39: using GRADE-ADOLOPMENT to adopt, adapt or create contextualized recommendations from source guidelines and evidence syntheses Open

Miloslav Klugar, Tamara Lotfi, Andrea Darzi, Marge Reinap, Jitka Klugarová , et al. · 2024

Using Bibliometrics to Detect Unconventional Authorship Practices and Examine Their Impact on Global Research Metrics, 2019-2023 Open

Lokman I. Meho, Elie A. Akl · 2024

Between 2019 and 2023, sixteen universities increased their research output by more than fifteen times the global average, alongside significant changes in authorship dynamics (e.g., decreased first authorship, increased numbers of hyperpr…

Using Bibliometrics to Detect Unconventional Authorship Practices and Examine Their Impact on Global Research Metrics, 2019-2023 Open

Lokman I. Meho, Elie A. Akl · 2024

Between 2019 and 2023, sixteen universities increased their research output by over fifteen times the global average, alongside significant changes in authorship dynamics (e.g., decreased first authorship, rise in hyperprolific authors, in…

Understanding contextual and practical factors to inform WHO recommendations on using chest imaging to monitor COVID-19 pulmonary sequelae: a qualitative study exploring stakeholders’ perspective Open

Gladys Honein‐AbouHaidar, Cynthia Rizkallah, Imad Bou Akl, Gian Paolo Morgano, Tereza Vrbová , et al. · 2024

Impact of a Mobile, Cloud-Based Care-Coordination Platform on Door-to-Balloon Time in Patients With STEMI: Initial Results Open

Ahmed Aldajani, Omar Chaabo, François Brouillette, Khalil Anchouche, Y. Lachance , et al. · 2024

Care-coordination platforms may optimize ST-elevation myocardial infarction (STEMI) treatment delays. This study aimed to assess the impact of Stenoa use on treatment delays in STEMI patients. We conducted a retrospective cohort study on l…

Reporting Conflicts of Interest and Funding in Health Care Guidelines: The RIGHT-COI&F Checklist Open

Yangqin Xun, Janne Estill, Joanne Khabsa, Iván D. Flórez, Gordon Guyatt , et al. · 2024

The Fundamental Research Funds for the Central Universities of China.

GRADE Guidance 40: the GRADE evidence-to-decision framework for environmental and occupational health Open

Emily Senerth, Paul Whaley, Elie A. Akl, Brandy Beverly, Pablo Alonso‐Coello , et al. · 2024

Decision considerations in EOH are accommodated within the GRADE EtD framework.• Limited uptake of the GRADE EtD in EOH is likely due to other factors and not incompatibility of the EtD framework with EOH decision-making considerations.• G…

The effects of public health and social measures (PHSM) implemented during the COVID‐19 pandemic: An overview of systematic reviews Open

Racha Fadlallah, Fadi El‐Jardali, Lama Bou Karroum, Nour Kalach, Reem Hoteit , et al. · 2024

Introduction To systematically review the effectiveness and unintended health and socioeconomic consequences of public health and social measures (PHSM) aimed at reducing the scale and risk of transmission of coronavirus disease 2019 (COVI…

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