Egon A. Ozer
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View article: Flavin affinity for the reductase HpaC differentially sensitizes Neisseria gonorrhoeae during Type IV pilus-dependent killing
Flavin affinity for the reductase HpaC differentially sensitizes Neisseria gonorrhoeae during Type IV pilus-dependent killing Open
The Neisseria gonorrhoeae Type IV pilus is a dynamic fiber involved in host cell attachment, DNA transformation, twitching motility, and evading the innate immune system. We previously reported that pilus expression affects iron homeostasi…
View article: Culture and Adaptation of <i>Pseudomonas aeruginosa</i> During Early Infection in Children With Cystic Fibrosis
Culture and Adaptation of <i>Pseudomonas aeruginosa</i> During Early Infection in Children With Cystic Fibrosis Open
Background Relatively little is known about Pseudomonas aeruginosa lineages during early infection in individuals with cystic fibrosis (CF). The Early Pseudomonas Infection Control Clinical Trial (EPIC-CT), which treated individuals with C…
View article: Intra-Host Evolution of SARS-CoV-2 During Persistent Infection of Pediatric COVID-19 Patients
Intra-Host Evolution of SARS-CoV-2 During Persistent Infection of Pediatric COVID-19 Patients Open
The Coronavirus disease 2019 (COVID-19) pandemic had a profound global impact, yet children exhibited distinct clinical and epidemiological patterns compared to adults. Pediatric cases of severe acute respiratory syndrome coronavirus 2 (SA…
View article: Pharmacodynamic insights to support pneumonia treatment in a patient co-infected with two carbapenem-resistant bacteria
Pharmacodynamic insights to support pneumonia treatment in a patient co-infected with two carbapenem-resistant bacteria Open
Identifying optimal antibiotic therapy for patients infected with extensively resistant bacteria is challenging, particularly when there are multiple organisms at the infection site. Personalized time-kill assays (TKAs) can be used to test…
View article: Large language models accurately identify immunosuppression in intensive care unit patients
Large language models accurately identify immunosuppression in intensive care unit patients Open
Objective Rule-based structured data algorithms and natural language processing (NLP) approaches applied to unstructured clinical notes have limited accuracy and poor generalizability for identifying immunosuppression. Large language model…
View article: <i>Scheffersomyces spartinae</i> Fungemia among Pediatric Patients, Pakistan, 2020–2024
<i>Scheffersomyces spartinae</i> Fungemia among Pediatric Patients, Pakistan, 2020–2024 Open
Prevalence of emerging fungal infections is increasing, particularly among immunocompromised persons, children, and older persons. We report 108 cases of Scheffersomyces spartinae infection in pediatric patients from Karachi and other citi…
View article: Draft genome sequences of <i>Stenotrophomonas maltophilia</i> strains UPSm1, UPSm3, and UPSm5 and <i>Stenotrophomonas pavanii</i> strain UPSm2
Draft genome sequences of <i>Stenotrophomonas maltophilia</i> strains UPSm1, UPSm3, and UPSm5 and <i>Stenotrophomonas pavanii</i> strain UPSm2 Open
We report the draft genome sequences of Stenotrophomonas maltophilia strains UPSm1, UPSm3, and UPSm5 and Stenotrophomonas pavanii strain UPSm2, all of which had been isolated from the respiratory tract of human patients. The genome assembl…
View article: Individual target pharmacokinetic/pharmacodynamic attainment rates among cefepime-treated patients admitted to the ICU with hospital-acquired pneumonia with and without ECMO
Individual target pharmacokinetic/pharmacodynamic attainment rates among cefepime-treated patients admitted to the ICU with hospital-acquired pneumonia with and without ECMO Open
Cefepime (FEP) is used for hospital- and ventilator-associated pneumonia when Pseudomonas aeruginosa is involved. However, its pharmacokinetics (PK) in severe pneumonia necessitating extracorporeal membrane oxygenation (ECMO) remain unclea…
View article: Shared interactions of six neurotropic viruses with 38 human proteins: a computational and literature-based exploration of viral interactions and hijacking of human proteins in neuropsychiatric disorders
Shared interactions of six neurotropic viruses with 38 human proteins: a computational and literature-based exploration of viral interactions and hijacking of human proteins in neuropsychiatric disorders Open
The study indicates a substantial number of energetically favorable interactions between human proteins and selected viral proteins, underscoring the complexity and breadth of viral strategies to hijack host cellular mechanisms. Further in…
View article: P-1224. Individual Target Pharmacokinetic/Pharmacodynamic Attainment Rates among Cefepime-treated Patients Admitted to the ICU with Hospital-Acquired Pneumonia with and without ECMO
P-1224. Individual Target Pharmacokinetic/Pharmacodynamic Attainment Rates among Cefepime-treated Patients Admitted to the ICU with Hospital-Acquired Pneumonia with and without ECMO Open
Background The impact of extracorporeal membrane oxygenation (EMCO) on cefepime (FEP) pharmacokinetics (PK) in the absence of renal replacement therapy (RRT) is unclear. Figure 1. Observed versus predicted cefepime plasma concentrations in…
View article: The impact of remdesivir on SARS-CoV-2 evolution in vivo
The impact of remdesivir on SARS-CoV-2 evolution in vivo Open
The impact of remdesivir on SARS-CoV-2 diversity and evolution in vivo has remained unclear. In this single-center, retrospective cohort study, we assessed SARS-CoV-2 diversification and diversity over time in a cohort of hospitalized pati…
View article: Updated Surveillance Metrics and History of the COVID-19 Pandemic (2020-2023) in East Asia and the Pacific Region: Longitudinal Trend Analysis
Updated Surveillance Metrics and History of the COVID-19 Pandemic (2020-2023) in East Asia and the Pacific Region: Longitudinal Trend Analysis Open
Background This study updates the COVID-19 pandemic surveillance in East Asia and the Pacific region that we first conducted in 2020 with 2 additional years of data for the region. Objective First, we aimed to measure whether there was an …
View article: Transtemporal Endoscopic Deep Plane Face Lift
Transtemporal Endoscopic Deep Plane Face Lift Open
Background: Facial aging involves multifactorial changes affecting the bone, superficial musculoaponeurotic system, fat pads, and skin, primarily manifesting as the downward displacement of these structures. The transtemporal endoscopic de…
View article: Updated Surveillance Metrics and History of the COVID-19 Pandemic (2020-2023) in Canada: Longitudinal Trend Analysis
Updated Surveillance Metrics and History of the COVID-19 Pandemic (2020-2023) in Canada: Longitudinal Trend Analysis Open
Background This study provides an update on the status of the COVID-19 pandemic in Canada, building upon our initial analysis conducted in 2020 by incorporating an additional 2 years of data. Objective This study aims to (1) summarize the …
View article: Linezolid-resistant Enterococcus faecium clinical isolates from Pakistan: a genomic analysis
Linezolid-resistant Enterococcus faecium clinical isolates from Pakistan: a genomic analysis Open
Our findings show the circulation of CC17 sequence types with a known outbreak potential and we identified molecular mechanisms of resistance that were not previously reported from Pakistan.
View article: The global population stru cture of Lacticaseibacillus rhamnosus and its application to an investigation of a rare case of infective endocarditis
The global population stru cture of Lacticaseibacillus rhamnosus and its application to an investigation of a rare case of infective endocarditis Open
Background Lacticaseibacillus (formerly Lactobacillus ) rhamnosus is widely used in probiotics or food supplements to promote microbiome health and may also be part of the normal microbiota of the human gastrointestinal tract. However, it …
View article: South Asia’s COVID-19 History and Surveillance: Updated Epidemiological Assessment
South Asia’s COVID-19 History and Surveillance: Updated Epidemiological Assessment Open
Background This study updates our findings from the COVID-19 pandemic surveillance we first conducted in South Asia in 2020 with 2 additional years of data for the region. We assess whether COVID-19 had transitioned from pandemic to endemi…
View article: Updated Surveillance Metrics and History of the COVID-19 Pandemic (2020-2023) in Sub-Saharan Africa: Longitudinal Trend Analysis
Updated Surveillance Metrics and History of the COVID-19 Pandemic (2020-2023) in Sub-Saharan Africa: Longitudinal Trend Analysis Open
Background This study updates the initial COVID-19 pandemic surveillance in sub-Saharan Africa (SSA) from 2020 by providing 2 additional years of data for the region. Objective First, we aimed to measure whether there was an expansion or c…
View article: Surveillance Metrics and History of the COVID-19 Pandemic in Central Asia: Updated Epidemiological Assessment
Surveillance Metrics and History of the COVID-19 Pandemic in Central Asia: Updated Epidemiological Assessment Open
Background This study updates the COVID-19 pandemic surveillance in Central Asia we conducted during the first year of the pandemic by providing 2 additional years of data for the region. The historical context provided through additional …
View article: Deviations in RSV epidemiological patterns and population structures in the United States following the COVID-19 pandemic
Deviations in RSV epidemiological patterns and population structures in the United States following the COVID-19 pandemic Open
Respiratory Syncytial Virus (RSV) is a leading cause of acute respiratory tract infection, with the greatest impact on infants, immunocompromised individuals, and older adults. RSV prevalence decreased substantially in the United States (U…
View article: Updated Surveillance Metrics and History of the COVID-19 Pandemic (2020-2023) in Latin America and the Caribbean: Longitudinal Trend Analysis
Updated Surveillance Metrics and History of the COVID-19 Pandemic (2020-2023) in Latin America and the Caribbean: Longitudinal Trend Analysis Open
Background In May 2020, the World Health Organization (WHO) declared Latin America and the Caribbean (LAC) the epicenter of the COVID-19 pandemic, with over 40% of worldwide COVID-19–related deaths at the time. This high disease burden was…
View article: Updated Surveillance Metrics and History of the COVID-19 Pandemic (2020-2023) in the Middle East and North Africa: Longitudinal Trend Analysis
Updated Surveillance Metrics and History of the COVID-19 Pandemic (2020-2023) in the Middle East and North Africa: Longitudinal Trend Analysis Open
Background This study updates the COVID-19 pandemic surveillance in the Middle East and North Africa (MENA) we first conducted in 2020 with 2 additional years of data for the region. Objective The objective of this study is to determine wh…
View article: Updated Surveillance Metrics and History of the COVID-19 Pandemic (2020-2023) in Europe: Longitudinal Trend Analysis
Updated Surveillance Metrics and History of the COVID-19 Pandemic (2020-2023) in Europe: Longitudinal Trend Analysis Open
Background In this study, we built upon our initial research published in 2020 by incorporating an additional 2 years of data for Europe. We assessed whether COVID-19 had shifted from the pandemic to endemic phase in the region when the Wo…
View article: Prolonged exposure to lung-derived cytokines is associated with activation of microglia in patients with COVID-19
Prolonged exposure to lung-derived cytokines is associated with activation of microglia in patients with COVID-19 Open
BACKGROUNDSurvivors of pneumonia, including SARS-CoV-2 pneumonia, are at increased risk for cognitive dysfunction and dementia. In rodent models, cognitive dysfunction following pneumonia has been linked to the systemic release of lung-der…
View article: Genomic characterization of SARS-CoV-2 in Guinea, West Africa
Genomic characterization of SARS-CoV-2 in Guinea, West Africa Open
SARS-CoV-2 has claimed several million lives since its emergence in late 2019. The ongoing evolution of the virus has resulted in the periodic emergence of new viral variants with distinct fitness advantages, including enhanced transmissio…
View article: Author Response: Quantity of SARS-CoV-2 RNA copies exhaled per minute during natural breathing over the course of COVID-19 infection
Author Response: Quantity of SARS-CoV-2 RNA copies exhaled per minute during natural breathing over the course of COVID-19 infection Open
SARS-CoV-2 is spread through exhaled breath of infected individuals. A fundamental question in understanding transmission of SARS-CoV-2 is how much virus an individual is exhaling into the environment while they breathe, over the course of…
View article: Quantity of SARS-CoV-2 RNA copies exhaled per minute during natural breathing over the course of COVID-19 infection
Quantity of SARS-CoV-2 RNA copies exhaled per minute during natural breathing over the course of COVID-19 infection Open
SARS-CoV-2 is spread through exhaled breath of infected individuals. A fundamental question in understanding transmission of SARS-CoV-2 is how much virus an individual is exhaling into the environment while they breathe, over the course of…