Elif Soyak Aytekin
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View article: Beyond the Classical Triad: Atypical Presentations and Regulatory T Cell Phenotyping in a Cohort of IPEX Patients
Beyond the Classical Triad: Atypical Presentations and Regulatory T Cell Phenotyping in a Cohort of IPEX Patients Open
View article: Amyloidosis in Human Inborn Errors of Immunity Predicts Poor Prognosis
Amyloidosis in Human Inborn Errors of Immunity Predicts Poor Prognosis Open
View article: Improvement in symptom severity, asthma control, and quality of life in pediatric patients with seasonal allergic rhinitis
Improvement in symptom severity, asthma control, and quality of life in pediatric patients with seasonal allergic rhinitis Open
Objectives: To evaluate the allergic rhinitis (AR) symptoms, asthma control, and quality of life (QoL) outcomes following treatment in children with seasonal allergic rhinitis (SAR), with and without asthma. Methods: Children diagnosed wit…
View article: Changes in anaphylaxis trends and characteristics in emergency department admissions in Türkiye: From 2015 to 2021 based on the Ministry of Health database
Changes in anaphylaxis trends and characteristics in emergency department admissions in Türkiye: From 2015 to 2021 based on the Ministry of Health database Open
View article: Correction to: Genetic Evaluation of the Patients with Clinically Diagnosed Inborn Errors of Immunity by Whole Exome Sequencing: Results from a Specialized Research Center for Immunodeficiency in Türkiye
Correction to: Genetic Evaluation of the Patients with Clinically Diagnosed Inborn Errors of Immunity by Whole Exome Sequencing: Results from a Specialized Research Center for Immunodeficiency in Türkiye Open
View article: Inborn Errors of Immunity in Adults with Autoimmune Liver Diseases
Inborn Errors of Immunity in Adults with Autoimmune Liver Diseases Open
We detect ID in about one-fifth of the patients with AILD. The present study showed a significant risk of IEI that is blurred by the shadow of immune suppressive treatments. We suggest that the AILD patients with ID will benefit from the i…
View article: The treatment journey of children with moderate to severe atopic dermatitis in Türkiye: unmet needs
The treatment journey of children with moderate to severe atopic dermatitis in Türkiye: unmet needs Open
Background. Atopic dermatitis (AD) substantially burdens individuals, families, and healthcare systems. We aimed to document the treatment journey of pediatric patients with moderate-to-severe AD in a referral center based in our country. …
View article: Genetic evaluation of the patients with clinically diagnosed inborn errors of immunity by whole exome sequencing: Results from a specialized research center for immunodeficiency in Türkiye
Genetic evaluation of the patients with clinically diagnosed inborn errors of immunity by whole exome sequencing: Results from a specialized research center for immunodeficiency in Türkiye Open
Molecular diagnosis of inborn errors of immunity (IEI) poses critical implications for patient’s long-term prognosis, treatment options, and genetic counseling. Over the past decade, the broader utilization of next-generation sequencing (N…
View article: Evaluation of Klebsiella infections in the tertiary neonatal intensive care unit
Evaluation of Klebsiella infections in the tertiary neonatal intensive care unit Open
Aim: In this study, we aimed to determine the frequency, demographic characteristics, associated risk factors, resistance patterns and factors affecting mortality and morbidity of Klebsiella infections in hospitalized neonatal patients.Mat…
View article: Diagnostic accuracy of the <scp>ALEX<sup>2</sup></scp> test in peanut‐sensitized children
Diagnostic accuracy of the <span>ALEX<sup>2</sup></span> test in peanut‐sensitized children Open
To the editor, The fundamental concept when diagnosing allergies is that detection of immunoglobulin E (IgE) sensitization and the presence of allergy are not identical. Complementary to conventional testing that is based on allergen extra…
View article: APECED and the place of AIRE in the puzzle of the immune network associated with autoimmunity
APECED and the place of AIRE in the puzzle of the immune network associated with autoimmunity Open
In the last 20 years, discoveries about the autoimmune regulator (AIRE) protein and its critical role in immune tolerance have provided fundamental insights into understanding the molecular basis of autoimmunity. This review provides a com…
View article: Diagnostic accuracy of the ALEX2 test in peanut sensitized children
Diagnostic accuracy of the ALEX2 test in peanut sensitized children Open
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View article: Diagnostic accuracy of the ALEX2 test in peanut sensitized children
Diagnostic accuracy of the ALEX2 test in peanut sensitized children Open
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View article: Diagnostic accuracy of the ALEX2 test in peanut sensitized children
Diagnostic accuracy of the ALEX2 test in peanut sensitized children Open
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View article: Diagnostic accuracy of the ALEX2 test in peanut sensitized children
Diagnostic accuracy of the ALEX2 test in peanut sensitized children Open
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View article: Combining sIgE to multiplexed peanut components with skin prick testing improves diagnostic accuracy for peanut allergy
Combining sIgE to multiplexed peanut components with skin prick testing improves diagnostic accuracy for peanut allergy Open
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View article: Diagnostic accuracy of the ALEX2 test in peanut sensitized children
Diagnostic accuracy of the ALEX2 test in peanut sensitized children Open
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View article: Recurrent Oral Aphtha, Diarrhea, Pneumonia, And Respiratory Distress Since Infancy: STAT1 GOF defect
Recurrent Oral Aphtha, Diarrhea, Pneumonia, And Respiratory Distress Since Infancy: STAT1 GOF defect Open
Backgrounds: Mutations in DNA-binding domains of STAT1 lead to delayed STAT1 dephosphorylation and afterwards gain-of-function. The clinical phenotype is broad and can include chronic mucocutaneous candidiasis and/or combined immunodeficie…
View article: Obesity is a risk factor for decrease in lung function after COVID‐19 infection in children with asthma
Obesity is a risk factor for decrease in lung function after COVID‐19 infection in children with asthma Open
Introduction It is not clear whether asthma, the most frequent chronic disease in childhood, is a risk for severe SARS‐CoV‐2 infection in the pediatric population and how SARS‐CoV‐2 infection affects the lung functions in these patients. P…
View article: Hematopoietic stem cell transplantation complicated with EBV associated hemophagocytic lymphohistiocytosis in a patient with DOCK2 deficiency
Hematopoietic stem cell transplantation complicated with EBV associated hemophagocytic lymphohistiocytosis in a patient with DOCK2 deficiency Open
Background. Dedicator of cytokinesis 2 (DOCK2) deficiency is a rare autosomal recessive combined immunodeficiency presenting with very early onset, severe bacterial and viral infections. In DOCK2 deficiency; T, B and NK cell numbers are de…
View article: Allergic reactions during childhood vaccination and management
Allergic reactions during childhood vaccination and management Open
Background. Vaccination is one of the most effective public health tools to prevent a variety of infectious diseases. However, concerns about vaccine related adverse effects cause difficulties in clinical practice. Methods. This review was…
View article: Parental Perspectives on the Implementation of House Dust Mite Avoidance Measures for Children with House Dust Mite Sensitization
Parental Perspectives on the Implementation of House Dust Mite Avoidance Measures for Children with House Dust Mite Sensitization Open
Objective: The avoidance of house dust mite (HDM) is crucial in the management of HDM allergies. We aimed to demonstrate the implementation and perspective of the parents whose children had HDM allergy/sensitization to HDM avoidance measur…
View article: Author response for "Multicentric Castleman disease in a DOCK8‐deficient patient with Orf virus infection"
Author response for "Multicentric Castleman disease in a DOCK8‐deficient patient with Orf virus infection" Open
View article: Author response for "Multicentric Castleman disease in a DOCK8‐deficient patient with Orf virus infection"
Author response for "Multicentric Castleman disease in a DOCK8‐deficient patient with Orf virus infection" Open
View article: Clinical and laboratory findings in patients with leukocyte adhesion deficiency type I: A multicenter study in Turkey
Clinical and laboratory findings in patients with leukocyte adhesion deficiency type I: A multicenter study in Turkey Open
Leukocyte adhesion deficiency type I is a rare primary immunodeficiency disorder characterized by mutations in the ITGB2 gene encoding CD18. We present clinical and immunological features of 15 patients with leukocyte adhesion deficiency t…
View article: Differential diagnosis of primary immunodeficiency in patients with BCGitis and BCGosis: A single‐centre study
Differential diagnosis of primary immunodeficiency in patients with BCGitis and BCGosis: A single‐centre study Open
BCG infections occur more frequently in patients with underlying primary immunodeficiency disease (PIDD). In this study, we aimed to evaluate the ratio of PIDD in the patients with BCG infections. Patients with BCG infections were analyzed…
View article: Genomic Spectrum and Phenotypic Heterogeneity of Human IL-21 Receptor Deficiency
Genomic Spectrum and Phenotypic Heterogeneity of Human IL-21 Receptor Deficiency Open
View article: Clinical and Laboratory Findings in Patients with Leukocyte Adhesion Deficiency Type I: A Multicenter Study in Turkey
Clinical and Laboratory Findings in Patients with Leukocyte Adhesion Deficiency Type I: A Multicenter Study in Turkey Open
Leukocyte adhesion deficiency type I is rare primary immunodeficiency disorder characterized by mutations in the ITGB2 gene encoding CD18. We present clinical and immunological features of 15 patients with leukocyte adhesion deficiency typ…
View article: A RARE INVOLVEMENT OF CENTRAL NERVOUS SYSTEM INVOLVEMENT DUE TO CTLA-4 GENE DEFECT
A RARE INVOLVEMENT OF CENTRAL NERVOUS SYSTEM INVOLVEMENT DUE TO CTLA-4 GENE DEFECT Open
Cytotoxic T-lymphocyte antigen-4 (CTLA-4) haploinsufficiency is the defect of one of the checkpoint inhibitory molecules and defined as a primary immunodeficiency characterized by immune dysregulation. A 26-year-old female with a history o…
View article: Flow Cytometric Analysis of T Cell Vβ Repertoire in Common Variable Immunodeficiency Patients with TACI Mutations
Flow Cytometric Analysis of T Cell Vβ Repertoire in Common Variable Immunodeficiency Patients with TACI Mutations Open
Objective: TCR (T Cell Receptor) which is expressed on T cells is responsible for recognizing antigens presented by HLA molecules of the APCs (Antigen Presenting Cells) and initiation of the immune response. It has been reported that TACI …