Elin Manell
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View article: Therapeutic Reprogramming of Glioblastoma Phenotypic States Using Multifunctional Heparin Nanoparticles
Therapeutic Reprogramming of Glioblastoma Phenotypic States Using Multifunctional Heparin Nanoparticles Open
Glioblastomas (GB) are the most common and deadly primary malignant brain tumors due to their infiltrative growth and resistance to conventional therapies. GB cell plasticity and differentiation into drug‐resistant mesenchymal‐like (MES) s…
View article: A new principle to attenuate ischemia-reperfusion injury in kidney transplantation
A new principle to attenuate ischemia-reperfusion injury in kidney transplantation Open
Ischemia-reperfusion injury in transplantation remains a significant clinical challenge with regard to both short-term and long-term complications. In this study, we developed a new amphiphilic construct, polyethylene glycol (PEG)-conjugat…
View article: A novel variation of the mixed lymphocyte reaction for measuring T cell responses to skin-specific antigens of pigs
A novel variation of the mixed lymphocyte reaction for measuring T cell responses to skin-specific antigens of pigs Open
Skin and vascularized composite allografts (VCA) containing skin are transplanted to restore form and function of tissues after major injuries. Skin has long been recognized as being particularly immunogenic, causing high risk of rejection…
View article: Application of enzyme-linked immunosorbent assay to detect antimicrobial peptides in human intestinal lumen
Application of enzyme-linked immunosorbent assay to detect antimicrobial peptides in human intestinal lumen Open
View article: A battery-less implantable glucose sensor based on electrical impedance spectroscopy
A battery-less implantable glucose sensor based on electrical impedance spectroscopy Open
View article: Age Rather Than Supplementation with Oat β-Glucan Influences Development of the Intestinal Microbiota and SCFA Concentrations in Suckling Piglets
Age Rather Than Supplementation with Oat β-Glucan Influences Development of the Intestinal Microbiota and SCFA Concentrations in Suckling Piglets Open
The effects of early supplementation with oat β-glucan during the suckling period on piglet gut microbiota composition, concentrations of short-chain fatty acids, and gut physiological markers were assessed. Fifty piglets from five litters…
View article: Training Pigs for Oral Glucose Tolerance Test—Six Years’ Experience of a Refined Model
Training Pigs for Oral Glucose Tolerance Test—Six Years’ Experience of a Refined Model Open
Animal models of human diseases are important in biomedical research. When using animals for scientific purposes, the 3Rs (replace, reduce, refine) should be considered. Refinement of animal models is essential to ensure best use of animal…
View article: Correction to: Bioavailability of subcutaneous and intramuscular administrated buprenorphine in New Zealand White rabbits
Correction to: Bioavailability of subcutaneous and intramuscular administrated buprenorphine in New Zealand White rabbits Open
An amendment to this paper has been published and can be accessed via the original article.
View article: Exploring the GLP-1–GLP-1R axis in porcine pancreas and gastrointestinal tract in vivo by ex vivo autoradiography
Exploring the GLP-1–GLP-1R axis in porcine pancreas and gastrointestinal tract in vivo by ex vivo autoradiography Open
Introduction Glucagon-like peptide-1 (GLP-1) increases insulin secretion from pancreatic beta-cells and GLP-1 receptor (GLP-1R) agonists are widely used as treatment for type 2 diabetes mellitus. Studying occupancy of the GLP-1R in various…
View article: Bioavailability of subcutaneous and intramuscular administrated buprenorphine in New Zealand White rabbits
Bioavailability of subcutaneous and intramuscular administrated buprenorphine in New Zealand White rabbits Open
View article: The effect of housing environment on bone healing in a critical radius defect in New Zealand White rabbits
The effect of housing environment on bone healing in a critical radius defect in New Zealand White rabbits Open
In animal studies on bone healing, the effect of housing space and physical activity are seldom taken into account. Bone formation was evaluated in New Zealand White rabbits (mean ± SEM BW: 3.9 ± 0.11 kg) with a critical bone defect after …
View article: Additional file 1 of Bioavailability of subcutaneous and intramuscular administrated buprenorphine in New Zealand White rabbits
Additional file 1 of Bioavailability of subcutaneous and intramuscular administrated buprenorphine in New Zealand White rabbits Open
Additional file 1.
View article: Refinement of porcine models in diabetes and transplantation research
Refinement of porcine models in diabetes and transplantation research Open
Animal models are widely used in biomedical research aiming to prevent and improve treatments of diseases. The 3Rs (replace, reduce, refine) are considered when working with laboratory animals. Socialisation and training of pigs in researc…
View article: Pancreatic perfusion and its response to glucose as measured by simultaneous PET/MRI
Pancreatic perfusion and its response to glucose as measured by simultaneous PET/MRI Open
View article: Establishment of a Refined Oral Glucose Tolerance Test in Pigs, and Assessment of Insulin, Glucagon and Glucagon-Like Peptide-1 Responses
Establishment of a Refined Oral Glucose Tolerance Test in Pigs, and Assessment of Insulin, Glucagon and Glucagon-Like Peptide-1 Responses Open
Diabetes mellitus is increasing worldwide and reliable animal models are important for progression of the research field. The pig is a commonly used large animal model in diabetes research and the present study aimed to refine a model for …