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View article: Evolutionary analyses of the animal glycosyltransferase family 54 reveals two β1,4-N-acetylglucosaminyltransferase families
Evolutionary analyses of the animal glycosyltransferase family 54 reveals two β1,4-N-acetylglucosaminyltransferase families Open
N-acetylglucosaminyltransferases involved in branched N-glycans synthesis, a major post-translational modification, are gathered in the CAZy glycosyltransferase family 54. To date, the origin and evolution of this biosynthetic pathway are …
View article: A Rapid and Sensitive MicroPlate Assay (MPSA) Using an Alkyne‐Modified CMP‐Sialic Acid Donor to Evaluate Human Sialyltransferase Specificity
A Rapid and Sensitive MicroPlate Assay (MPSA) Using an Alkyne‐Modified CMP‐Sialic Acid Donor to Evaluate Human Sialyltransferase Specificity Open
Human sialyltransferases primarily utilize CMP‐Sias, especially transferring Neu5Ac from CMP‐Neu5Ac to various acceptors. Advances in chemical biology have led to the synthesis of novel CMP‐Sia donors suitable for bioorthogonal reactions i…
View article: Charged Amino Acids in the Transmembrane Helix Strongly Affect the Enzyme Activity of Aromatase
Charged Amino Acids in the Transmembrane Helix Strongly Affect the Enzyme Activity of Aromatase Open
Estrogens play critical roles in embryonic development, gonadal sex differentiation, behavior, and reproduction in vertebrates and in several human cancers. Estrogens are synthesized from testosterone and androstenedione by the endoplasmic…
View article: Towards Molecular Understanding of the Functional Role of UbiJ-UbiK2 Complex in Ubiquinone Biosynthesis by Multiscale Molecular Modelling Studies
Towards Molecular Understanding of the Functional Role of UbiJ-UbiK2 Complex in Ubiquinone Biosynthesis by Multiscale Molecular Modelling Studies Open
Ubiquinone (UQ) is a polyisoprenoid lipid found in the membranes of bacteria and eukaryotes. UQ has important roles, notably in respiratory metabolisms which sustain cellular bioenergetics. Most steps of UQ biosynthesis take place in the c…
View article: A fusion peptide in preS1 and the human protein disulfide isomerase ERp57 are involved in hepatitis B virus membrane fusion process
A fusion peptide in preS1 and the human protein disulfide isomerase ERp57 are involved in hepatitis B virus membrane fusion process Open
Cell entry of enveloped viruses relies on the fusion between the viral and plasma or endosomal membranes, through a mechanism that is triggered by a cellular signal. Here we used a combination of computational and experimental approaches t…
View article: Author response: A fusion peptide in preS1 and the human protein disulfide isomerase ERp57 are involved in hepatitis B virus membrane fusion process
Author response: A fusion peptide in preS1 and the human protein disulfide isomerase ERp57 are involved in hepatitis B virus membrane fusion process Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Cell entry of enveloped viruses relies on …
View article: A phylogenetic view and functional annotation of the animal β1,3-glycosyltransferases of the GT31 CAZy family
A phylogenetic view and functional annotation of the animal β1,3-glycosyltransferases of the GT31 CAZy family Open
The formation of β1,3-linkages on animal glycoconjugates is catalyzed by a subset of β1,3-glycosyltransferases grouped in the Carbohydrate-Active enZYmes family glycosyltransferase-31 (GT31). This family represents an extremely diverse set…
View article: COVTree: Coevolution in OVerlapped sequences by Tree analysis server
COVTree: Coevolution in OVerlapped sequences by Tree analysis server Open
Overlapping genes are commonplace in viruses and play an important role in their function and evolution. For these genes, molecular coevolution may be seen as a mechanism to decrease the evolutionary constraints of amino acid positions in …
View article: Coevolution analysis of amino-acids reveals diversified drug-resistance solutions in viral sequences: a case study of hepatitis B virus
Coevolution analysis of amino-acids reveals diversified drug-resistance solutions in viral sequences: a case study of hepatitis B virus Open
The study of mutational landscapes of viral proteins is fundamental for the understanding of the mechanisms of cross-resistance to drugs and the design of effective therapeutic strategies based on several drugs. Antiviral therapy with nucl…
View article: Novel Zebrafish Mono-α2,8-sialyltransferase (ST8Sia VIII): An Evolutionary Perspective of α2,8-Sialylation
Novel Zebrafish Mono-α2,8-sialyltransferase (ST8Sia VIII): An Evolutionary Perspective of α2,8-Sialylation Open
The mammalian mono-α2,8-sialyltransferase ST8Sia VI has been shown to catalyze the transfer of a unique sialic acid residues onto core 1 O-glycans leading to the formation of di-sialylated O-glycosylproteins and to a lesser extent to diSia…
View article: Novel Zebrafish Mono-α2,8-sialyltransferase (ST8Sia VIII):An Evolutionary Perspective of α2,8-Sialylation
Novel Zebrafish Mono-α2,8-sialyltransferase (ST8Sia VIII):An Evolutionary Perspective of α2,8-Sialylation Open
The mammalian mono-α2,8-sialyltransferase ST8Sia VI has been shown to catalyze the transfer of a unique sialic acid residues onto core 1 O-glycans leading to the formation of di-sialylated O-glycosylproteins and to a lesser extent to diSia…
View article: Reconstruction of the sialylation pathway in the ancestor of eukaryotes
Reconstruction of the sialylation pathway in the ancestor of eukaryotes Open
The biosynthesis of sialylated molecules of crucial relevance for eukaryotic cell life is achieved by sialyltransferases (ST) of the CAZy family GT29. These enzymes are widespread in the Deuterostoma lineages and more rarely described in P…
View article: Tomato Apical Leaf Curl Virus: A Novel, Monopartite Geminivirus Detected in Tomatoes in Argentina
Tomato Apical Leaf Curl Virus: A Novel, Monopartite Geminivirus Detected in Tomatoes in Argentina Open
Plant viruses that are members of the Geminiviridae family have circular single-stranded DNA (ssDNA) genome and are responsible for major crop diseases worldwide. We have identified and characterized a novel monopartite geminivirus infecti…
View article: Protein–protein interactions leave evolutionary footprints: High molecular coevolution at the core of interfaces
Protein–protein interactions leave evolutionary footprints: High molecular coevolution at the core of interfaces Open
Protein–protein interactions are essential to all aspects of life. Specific interactions result from evolutionary pressure at the interacting interfaces of partner proteins. However, evolutionary pressure is not homogeneous within the inte…
View article: Highlights of the 1st Argentine Symposium of Young Bioinformatics Researchers (1SAJIB) organized by the ISCB RSG-Argentina
Highlights of the 1st Argentine Symposium of Young Bioinformatics Researchers (1SAJIB) organized by the ISCB RSG-Argentina Open
The 1st Argentine Symposium of Young Bioinformatics Researchers took place on 9-10 May 2016 at Universidad de Buenos Aires, Buenos Aires, Argentina. This event evolved from a previous meeting series known as Argentine Student Council Sympo…
View article: Highlights of the 1st Argentine Symposium of Young Bioinformatics Researchers (1SAJIB) organized by the ISCB RSG-Argentina
Highlights of the 1st Argentine Symposium of Young Bioinformatics Researchers (1SAJIB) organized by the ISCB RSG-Argentina Open
The 1st Argentine Symposium of Young Bioinformatics Researchers took place on 9-10 May 2016 at Universidad de Buenos Aires, Buenos Aires, Argentina. This event evolved from a previous meeting series known as Argentine Student Council Sympo…
View article: Phylogenetic-Derived Insights into the Evolution of Sialylation in Eukaryotes: Comprehensive Analysis of Vertebrate β-Galactoside α2,3/6-Sialyltransferases (ST3Gal and ST6Gal)
Phylogenetic-Derived Insights into the Evolution of Sialylation in Eukaryotes: Comprehensive Analysis of Vertebrate β-Galactoside α2,3/6-Sialyltransferases (ST3Gal and ST6Gal) Open
Cell surface of eukaryotic cells is covered with a wide variety of sialylated molecules involved in diverse biological processes and taking part in cell–cell interactions. Although the physiological relevance of these sialylated glycoconju…