Elina K. Cook
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View article: Neutrophil-mediated innate immune resistance to bacterial pneumonia is dependent on Tet2 function
Neutrophil-mediated innate immune resistance to bacterial pneumonia is dependent on Tet2 function Open
Individuals with clonal hematopoiesis of indeterminate potential (CHIP) are at increased risk of aging related health conditions and all-cause mortality, but whether CHIP affects risk of infection is much less clear. Using UK Biobank data,…
View article: Infection risk associated with clonal hematopoiesis of indeterminate potential is partly mediated by hematologic cancer transformation in the UK Biobank
Infection risk associated with clonal hematopoiesis of indeterminate potential is partly mediated by hematologic cancer transformation in the UK Biobank Open
View article: Association of Clonal Hematopoiesis of Indeterminate Potential with Worse Kidney Function and Anemia in Two Cohorts of Patients with Advanced Chronic Kidney Disease
Association of Clonal Hematopoiesis of Indeterminate Potential with Worse Kidney Function and Anemia in Two Cohorts of Patients with Advanced Chronic Kidney Disease Open
Background Clonal hematopoiesis of indeterminate potential (CHIP) is an inflammatory premalignant disorder resulting from acquired genetic mutations in hematopoietic stem cells. This condition is common in aging populations and associated …
View article: Overview of the Canadian Clinician Investigator Trainees’ research presented at the 2019 CSCI-CITAC Joint Meeting
Overview of the Canadian Clinician Investigator Trainees’ research presented at the 2019 CSCI-CITAC Joint Meeting Open
The 2019 Annual General Meeting and Young Investigators’ Forum of the Canadian Society for Clinical Investigation / Société Canadienne de Recherche Clinique (CSCI/SCRC) and Clinician Investigator Trainee Association of Canada / Association…
View article: Mutation of the Epigenetic Regulatortet2 Is Associated with Increased Inflammation in Pulmonary Arterial Hypertension
Mutation of the Epigenetic Regulatortet2 Is Associated with Increased Inflammation in Pulmonary Arterial Hypertension Open
View article: Piloting a long distance clinician scientist trainee mentorship match in Canada
Piloting a long distance clinician scientist trainee mentorship match in Canada Open
Clinician scientists are physicians who are uniquely trained to bridge the gap between scientific discovery and clinical practice. However, the challenges of integrating research and medicine are often not directly addressed in the clinici…
View article: Novel Mutations and Decreased Expression of the Epigenetic Regulator <i>TET2</i> in Pulmonary Arterial Hypertension
Novel Mutations and Decreased Expression of the Epigenetic Regulator <i>TET2</i> in Pulmonary Arterial Hypertension Open
Background: Pulmonary arterial hypertension (PAH) is a lethal vasculopathy. Hereditary cases are associated with germline mutations in BMPR2 and 16 other genes; however, these mutations occur in <25% of patients with idiopathic PAH and are…
View article: Newsletter Fall 2019: Clinician Investigator Trainee Association of Canada (CITAC)
Newsletter Fall 2019: Clinician Investigator Trainee Association of Canada (CITAC) Open
A message from Elina Cook (President): Demystifying and promoting the MD-PhD/MSc world—our progress Clinician Investigator Trainee Association of Canada (CITAC) seeks to promote, support and advocate for trainees whose goal is to become ph…
View article: Comorbid and inflammatory characteristics of genetic subtypes of clonal hematopoiesis
Comorbid and inflammatory characteristics of genetic subtypes of clonal hematopoiesis Open
Key Points CH may be associated with broader ill health (worse performance status, increased and potentially novel comorbidities). Serum interleukin-6 is elevated in people with CH and genetic subtypes, providing a view of the human system…
View article: Newsletter Spring 2019: Clinician Investigator Trainee Association of Canada (CITAC)
Newsletter Spring 2019: Clinician Investigator Trainee Association of Canada (CITAC) Open
Message from the President: Demystifying and promoting the MD-PhD/MD+ world Since its inception in 2006, the Clinician-Investigator Trainee Association of Canada (CITAC) has investigated, supported and promoted the needs of Canadian traine…
View article: Scientific Overview on CSCI-CITAC Annual General Meeting and 2016 Young Investigators' Forum
Scientific Overview on CSCI-CITAC Annual General Meeting and 2016 Young Investigators' Forum Open
The 2016 Annual General Meeting of the Canadian Society of Clinician Investigators (CSCI) and Clinician Investigator Trainee Association of Canada/Association des Cliniciens-Chercheurs en Formation du Canada (CITAC/ACCFC) was a national co…
View article: Randomized Phase II Study of Azacitidine Alone or in Combination With Lenalidomide or With Vorinostat in Higher-Risk Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia: North American Intergroup Study SWOG S1117
Randomized Phase II Study of Azacitidine Alone or in Combination With Lenalidomide or With Vorinostat in Higher-Risk Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia: North American Intergroup Study SWOG S1117 Open
Purpose Azacitidine is standard, first-line therapy in higher-risk myelodysplastic syndromes (MDS). Whether azacitidine-based combinations with lenalidomide or vorinostat produce superior overall response rates (ORRs) to azacitidine is not…
View article: Early biomarker for radiation-induced wounds: day one post-irradiation assessment using hemoglobin concentration measured from diffuse optical reflectance spectroscopy
Early biomarker for radiation-induced wounds: day one post-irradiation assessment using hemoglobin concentration measured from diffuse optical reflectance spectroscopy Open
Normal tissue radiation toxicities are evaluated subjectively and cannot predict the development of severe side-effects. Using a hand-held diffuse reflectance optical spectroscopy probe, we measured optical parameters in mouse skin 1-4 day…