Elina Mukherjee
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View article: Supplementary Figure S3 from SARC028 Samples Reveal an Interplay between TGF-β, IFN Signaling, and Low HLA Class I Expression as Contributors to Ewing Sarcoma Checkpoint Blockade Resistance
Supplementary Figure S3 from SARC028 Samples Reveal an Interplay between TGF-β, IFN Signaling, and Low HLA Class I Expression as Contributors to Ewing Sarcoma Checkpoint Blockade Resistance Open
Supplementary Figure S3. Correlation between tumor response and fold change in immune cell infiltration.
View article: Supplementary Figure S4 from SARC028 Samples Reveal an Interplay between TGF-β, IFN Signaling, and Low HLA Class I Expression as Contributors to Ewing Sarcoma Checkpoint Blockade Resistance
Supplementary Figure S4 from SARC028 Samples Reveal an Interplay between TGF-β, IFN Signaling, and Low HLA Class I Expression as Contributors to Ewing Sarcoma Checkpoint Blockade Resistance Open
Supplementary Figure S4. Enrichment of immunosuppressive proteins occurs in the Ewing TME following treatment with pembrolizumab.
View article: Supplementary Figure S8 from SARC028 Samples Reveal an Interplay between TGF-β, IFN Signaling, and Low HLA Class I Expression as Contributors to Ewing Sarcoma Checkpoint Blockade Resistance
Supplementary Figure S8 from SARC028 Samples Reveal an Interplay between TGF-β, IFN Signaling, and Low HLA Class I Expression as Contributors to Ewing Sarcoma Checkpoint Blockade Resistance Open
Supplementary Figure S8. Differentially expressed genes in Ewing sarcoma tumor cells associated with each cellular neighborhood.
View article: Supplementary Figure S6 from SARC028 Samples Reveal an Interplay between TGF-β, IFN Signaling, and Low HLA Class I Expression as Contributors to Ewing Sarcoma Checkpoint Blockade Resistance
Supplementary Figure S6 from SARC028 Samples Reveal an Interplay between TGF-β, IFN Signaling, and Low HLA Class I Expression as Contributors to Ewing Sarcoma Checkpoint Blockade Resistance Open
Supplementary Figure S6. Identification of groups of patients based on the frequency of spatially resolved cellular neighborhoods.
View article: Supplementary Figure S5 from SARC028 Samples Reveal an Interplay between TGF-β, IFN Signaling, and Low HLA Class I Expression as Contributors to Ewing Sarcoma Checkpoint Blockade Resistance
Supplementary Figure S5 from SARC028 Samples Reveal an Interplay between TGF-β, IFN Signaling, and Low HLA Class I Expression as Contributors to Ewing Sarcoma Checkpoint Blockade Resistance Open
Supplementary Figure S5. Correlations between protein levels in stroma at baseline and changes in tumor size from pre- to post-treatment.
View article: Supplementary Table S2 from SARC028 Samples Reveal an Interplay between TGF-β, IFN Signaling, and Low HLA Class I Expression as Contributors to Ewing Sarcoma Checkpoint Blockade Resistance
Supplementary Table S2 from SARC028 Samples Reveal an Interplay between TGF-β, IFN Signaling, and Low HLA Class I Expression as Contributors to Ewing Sarcoma Checkpoint Blockade Resistance Open
Supplementary Table S2. Genes included in the CosMx Human Universal Cell Characterization RNA Panel.
View article: Supplementary Table S1 from SARC028 Samples Reveal an Interplay between TGF-β, IFN Signaling, and Low HLA Class I Expression as Contributors to Ewing Sarcoma Checkpoint Blockade Resistance
Supplementary Table S1 from SARC028 Samples Reveal an Interplay between TGF-β, IFN Signaling, and Low HLA Class I Expression as Contributors to Ewing Sarcoma Checkpoint Blockade Resistance Open
Supplementary Table S1. Proteins included in the Nanostring GeoMx immuno-oncology panel.
View article: Supplementary Figure S9 from SARC028 Samples Reveal an Interplay between TGF-β, IFN Signaling, and Low HLA Class I Expression as Contributors to Ewing Sarcoma Checkpoint Blockade Resistance
Supplementary Figure S9 from SARC028 Samples Reveal an Interplay between TGF-β, IFN Signaling, and Low HLA Class I Expression as Contributors to Ewing Sarcoma Checkpoint Blockade Resistance Open
Supplementary Figure S9. HLA class I expression is modifiable and upregulated in Ewing sarcoma cells following interferon-gamma (IFNγ) treatment.
View article: Supplementary Figure S1 from SARC028 Samples Reveal an Interplay between TGF-β, IFN Signaling, and Low HLA Class I Expression as Contributors to Ewing Sarcoma Checkpoint Blockade Resistance
Supplementary Figure S1 from SARC028 Samples Reveal an Interplay between TGF-β, IFN Signaling, and Low HLA Class I Expression as Contributors to Ewing Sarcoma Checkpoint Blockade Resistance Open
Supplementary Figure S1. NKX2.2 staining in Ewing tumor TMA samples.
View article: Supplementary Figure S2 from SARC028 Samples Reveal an Interplay between TGF-β, IFN Signaling, and Low HLA Class I Expression as Contributors to Ewing Sarcoma Checkpoint Blockade Resistance
Supplementary Figure S2 from SARC028 Samples Reveal an Interplay between TGF-β, IFN Signaling, and Low HLA Class I Expression as Contributors to Ewing Sarcoma Checkpoint Blockade Resistance Open
Supplementary Figure S2. Quantification of immune cell subsets utilizing multiplex immunohistochemistry.
View article: Supplementary Figure S7 from SARC028 Samples Reveal an Interplay between TGF-β, IFN Signaling, and Low HLA Class I Expression as Contributors to Ewing Sarcoma Checkpoint Blockade Resistance
Supplementary Figure S7 from SARC028 Samples Reveal an Interplay between TGF-β, IFN Signaling, and Low HLA Class I Expression as Contributors to Ewing Sarcoma Checkpoint Blockade Resistance Open
Supplementary Figure S7. Spatial distribution of cells from each patient tumor biopsy and enumeration of the proportion of cells with in each spatially resolved cell neighborhoods in each biopsy.
View article: Figure 5 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma
Figure 5 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma Open
TGFβ inhibition during radiotherapy increases immune infiltration of Ewing sarcomas. A, Experimental schematic depicting the four treatment groups. B, Immunophenotyping was performed on single-cell suspensions derived from TC…
View article: Figure S4 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma
Figure S4 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma Open
Figure S4. CT imaging of mouse tumors demonstrates bony destruction when tumors are established in para-tibial location.
View article: Table S1 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma
Table S1 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma Open
Gene lists from comparisons
View article: Figure S14 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma
Figure S14 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma Open
Figure S14. The TC32 EwS cell line demonstrates increased sensitivity to radiation therapy compared to the A673 cell line in vitro.
View article: Table S3 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma
Table S3 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma Open
Cell counts
View article: Figure S16 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma
Figure S16 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma Open
Figure S16. Survival of mice treated with ± RER and ± radiation therapy.
View article: Figure S7 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma
Figure S7 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma Open
Figure S7. Bulk RNA sequencing was performed on TC32 Ewing sarcoma tumors developed in either hu-CD34+ or NSG mouse models.
View article: Figure S11 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma
Figure S11 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma Open
Figure S11. Distinct tumor transcriptional signatures following radiation therapy are noted in Ewing sarcomas developed in hu-cD34+ versus NSG mouse models.
View article: Figure S8 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma
Figure S8 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma Open
Figure S8. Ewing sarcoma tumors developed in hu-CD34+ mice demonstrate upregulation of ECM pathways.
View article: Figure 4 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma
Figure 4 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma Open
The trivalent ligand trap (RER) effectively depletes TGFβ in vivo.A, Schematic of the mechanism of action of TGFβ1 ligand trap RER and interaction with TGBRII receptor. B, Comparison of TGFβ1 levels in the serum of mic…
View article: Figure S15 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma
Figure S15 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma Open
Figure S15. Flow cytometry gating strategy.
View article: Figure S19 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma
Figure S19 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma Open
Figure S19. TGFβ signaling is decreased in tumors of mice that receive RER following radiation therapy as compared to mice that are treated with radiation therapy (RT) alone.
View article: Figure 2 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma
Figure 2 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma Open
Ewing sarcomas developed in the hu-CD34+ model are biologically and transcriptionally distinct from tumors developed in an immunodeficient model. A, Orthotopic Ewing sarcomas are successfully established in a humanized (h…
View article: Figure S18 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma
Figure S18 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma Open
Figure S18. Representative H&E images of mouse lungs used for metastatic quantification.
View article: Data from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma
Data from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma Open
Ewing sarcoma is an aggressive cancer diagnosed in adolescents and young adults. Inhibition of TGFβ is being tested in limited clinical trials for relapsed Ewing sarcoma. TGFβ is an immunosuppressive cytokine that exists in latent and acti…
View article: Figure S6 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma
Figure S6 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma Open
Figure S6. Human natural killer (NK) cells are present in the peripheral blood of humanized mice.
View article: Figure S1 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma
Figure S1 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma Open
Figure S1. TGFβ1 expression is present in the immune cell compartment of human Ewing tumors.
View article: Figure S17 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma
Figure S17 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma Open
Figure S17. EWS::FLI1 expression in tumors established in hu-mice.
View article: Figure S13 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma
Figure S13 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma Open
Figure S13. Radiation therapy induces upregulation of inflammatory pathways in Ewing sarcoma tumors developed in a hu-CD34+ mouse model.