Explanipedia

Daily prediction of next-day disease severity in critically ill patients: A prospective cohort study Open

Wenbo Zhang, Eline G. M. Cox, Èmese Robin Hélène Heijkoop, Manon Klaver, Peter H.J. van der Voort , et al. · 2025

Daily prediction models can predict next-day disease severity in overall, respiration, cardiovascular, and renal function amongst ICU patients. They offer clinical benefits within a range of probability thresholds and could support decisio…

Genetic association studies in critically ill patients: a systematic review Open

Wenbo Zhang, Nam Nguyen-Hoang, Sean C S Rivrud, Anne-Fleur Zandbergen, Yalan Yan , et al. · 2025

Human judgment error in the intensive care unit: a perspective on bias and noise Open

Ilse P Peringa, Eline G. M. Cox, Renske Wiersema, Iwan C.C. van der Horst, Rob R. Meijer , et al. · 2025

Quantification of facial cues for acute illness: a systematic scoping review Open

Iris Cramer, Eline G. M. Cox, Jip W T M de Kok, Jacqueline Koeze, Martje Visser , et al. · 2025

The definition of predictor and outcome variables in mortality prediction models: a scoping review and quality of reporting study Open

Eline G. M. Cox, Daniek A. M. Meijs, Laure Wynants, Jan-Willem E. M. Sels, Jacqueline Koeze , et al. · 2024

Boosting the accuracy of existing models by updating and extending: using a multicenter COVID-19 ICU cohort as a proxy Open

Daniek A. M. Meijs, Laure Wynants, Sander M. J. van Kuijk, Clarissa Scheeren, Anisa Hana , et al. · 2024

Bedside variables to guide decision-making in critically ill patients Open

Eline G. M. Cox · 2024

Patients admitted to the intensive care unit (ICU) suffer from various diseases and comorbidities. Only critically ill patients that require continuous care, organ support, or monitoring are admitted to the ICU. Frequent clinical examinati…

Facial appearance associates with longitudinal multi-organ failure: an ICU cohort study Open

Eline G. M. Cox, Bas C. T. van Bussel, Nerea Campillo Llamazares, Jan-Willem E. M. Sels, Marisa Onrust , et al. · 2024

Facial expression associates with longitudinal multi-organ failure: an ICU cohort study Open

Eline G. M. Cox, Bas C. T. van Bussel, Nerea Campillo Llamazares, Jan-Willem E. M. Sels, Marisa Onrust , et al. · 2024

Background Facial expression, at least unconsciously, may affect clinical decisions and treatments in the ICU. However, the association between objective clinical measurement of facial expression and multi-organ failure remains unknown. Th…

Genetic association studies in critically ill patients: protocol for a systematic review Open

Eline G. M. Cox, Wenbo Zhang, Peter H. J. van der Voort, Gerton Lunter, Frederik Keus , et al. · 2023

POS1356 ASSESSMENT OF THE EFFICACY OF COMBINATION OF ORAL ACETAMINOPHEN AND TOPICAL DICLOFENAC IN OSTEOARTHRITIS PAIN: INSIGHTS FROM A MODEL-BASED META-ANALYSIS Open

Vivek Sood, Liang Qin, Eline G. M. Cox, Iñaki F. Trocóniz, Oscar Della Pasqua · 2023

Background Osteoarthritis (OA) is a major cause of chronic pain and disability in older adults and currently affects approximately 300 million people worldwide ^[1]. In the absence of curative therapy, symptomatic drugs comprise …

Genetic association studies in critically ill patients: protocol for a systematic review Open

Eline G. M. Cox, Wenbo Zhang, Peter H. J. van der Voort, Gerton Lunter, Frederik Keus , et al. · 2023

Introduction Patients in the intensive care unit (ICU) are highly heterogeneous in characteristics, their clinical course and outcomes. Genetic variability may partly explain the variability and similarity in disease courses observed among…

External Validation of Mortality Prediction Models for Critical Illness Reveals Preserved Discrimination but Poor Calibration Open

Eline G. M. Cox, Renske Wiersema, Ruben J. Eck, Thomas Kaufmann, Anders Granholm , et al. · 2022

OBJECTIVES: In a recent scoping review, we identified 43 mortality prediction models for critically ill patients. We aimed to assess the performances of these models through external validation. DESIGN: Multicenter study. SETTING: External…

Trough anti-Xa activity after intermediate dose nadroparin for thrombosis prophylaxis in critically ill patients with COVID-19 and acute kidney injury Open

Ruben J. Eck, J. J. C. M. van de Leur, Renske Wiersema, Eline G. M. Cox, Wouter Bult , et al. · 2022

Right ventricular strain measurements in critically ill patients: an observational SICS sub-study Open

Madelon E. Vos, Eline G. M. Cox, Maaike R. Schagen, Bart Hiemstra, Adrian Wong , et al. · 2022

Calculated left ventricular outflow tract diameter for critically ill patients Open

Eline G. M. Cox, Jacqueline Koeze, Iwan C.C. van der Horst, Renske Wiersema · 2022

A fast and reliable left ventricular outflow diameter (LVOTd) estimation may aid in quickly estimating cardiac output. However, obtaining a correct LVOTd can be difficult in intensive care patients, potentially leading to errors and a card…

The simple observational critical care studies: estimations by students, nurses, and physicians of in-hospital and 6-month mortality Open

Eline G. M. Cox, Marisa Onrust, Madelon E. Vos, Wolter Paans, Willem Dieperink , et al. · 2021

De (on)nauwkeurigheid van de voorhoofdthermometer Open

Wolter Paans, Willem Dieperink, Eline G. M. Cox, Frank Doesburg · 2021

Temporal artery temperature measurements versus bladder temperature in critically ill patients, a prospective observational study Open

Eline G. M. Cox, Willem Dieperink, Renske Wiersema, Frank Doesburg, Ingeborg C. van der Meulen , et al. · 2020

Purpose Accurate measurement of body temperature is important for the timely detection of fever or hypothermia in critically ill patients. In this prospective study, we evaluated whether the agreement between temperature measurements obtai…

Bundled care in acute kidney injury in critically ill patients, a before-after educational intervention study Open

Jacqueline Koeze, Iwan C.C. van der Horst, Renske Wiersema, Frederik Keus, Willem Dieperink , et al. · 2020

Background Acute kidney injury (AKI) often occurs in critically ill patients. AKI is associated with mortality and morbidity. Interventions focusing on the reduction of AKI are suggested by the Kidney Disease: Improving Global Outcomes gui…

Six versus eight and twenty-eight scan sites for B-line assessment: differences in examination time and findings Open

Eline G. M. Cox, Renske Wiersema, Adrian Wong, Iwan C.C. van der Horst · 2020

Non-invasive oscillometric versus invasive arterial blood pressure measurements in critically ill patients: A post hoc analysis of a prospective observational study Open

Thomas Kaufmann, Eline G. M. Cox, Renske Wiersema, Bart Hiemstra, Ruben J. Eck , et al. · 2020

Should the ultrasound probe replace your stethoscope? A SICS-I sub-study comparing lung ultrasound and pulmonary auscultation in the critically ill Open

Eline G. M. Cox, Geert Koster, A. Baron, Thomas Kaufmann, Ruben J. Eck , et al. · 2020

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