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View article: Differences in incidence of post-induction hypotension depending on the time of day: a post-hoc propensity score matched analysis
Differences in incidence of post-induction hypotension depending on the time of day: a post-hoc propensity score matched analysis Open
Post-induction hypotension was more frequent in the morning compared to the afternoon. While this finding is in line with the presumed physiological mechanisms, it may be affected by unmeasured confounding. These findings should be replica…
View article: The role of blood pressure versus oxygen administration on cerebral oxygenation during and after anaesthesia induction
The role of blood pressure versus oxygen administration on cerebral oxygenation during and after anaesthesia induction Open
BACKGROUND The effect of anaesthesia induction on cerebral perfusion is complex due to the coinciding respiratory and haemodynamic changes that occur. OBJECTIVE To examine how changes in blood pressure and oxygen administration are related…
View article: Pre‐operative reference ranges for <scp>ROTEM</scp> <sup>®</sup> sigma in patients undergoing cardiac surgery: a secondary analysis of two prospective trial cohorts
Pre‐operative reference ranges for <span>ROTEM</span> <sup>®</sup> sigma in patients undergoing cardiac surgery: a secondary analysis of two prospective trial cohorts Open
Summary Introduction Rotational thromboelastometry (ROTEM ® ) is used widely in cardiac surgery. Reference ranges are derived from healthy volunteers but may not be interchangeable with those from patients undergoing cardiac surgery. Furth…
View article: Anesthesia Management for the Personalized External Aortic Root Support (PEARS) Procedure: A Single-Center Experience
Anesthesia Management for the Personalized External Aortic Root Support (PEARS) Procedure: A Single-Center Experience Open
The PEARS procedure appears to be a viable alternative for preventive replacement of the aorta in selected patients with aortic aneurysms. Anesthesia is safe; in particular, profound deliberate hypotension can be used without relevant comp…
View article: The hypotension prediction index versus mean arterial pressure in predicting intraoperative hypotension
The hypotension prediction index versus mean arterial pressure in predicting intraoperative hypotension Open
BACKGROUND The hypotension prediction index (HPI) predicts hypotension, with randomised trials showing a significant reduction in hypotension-related metrics. However, the reliability of previous validation studies is debated, and it's unc…
View article: Interpretation of Viscoelastic Hemostatic Assays in Cardiac Surgery Patients: Importance of Clinical Context
Interpretation of Viscoelastic Hemostatic Assays in Cardiac Surgery Patients: Importance of Clinical Context Open
BACKGROUND: Rotational thromboelastometry (ROTEM) is widely used for point-of-care coagulation testing to reduce blood transfusions. Accurate interpretation of ROTEM data is crucial and requires substantial training. This study investigate…
View article: The influence of anesthetic drug strategy on the incidence of post-induction hypotension in elective, non-cardiac surgery – A prospective observational cohort study
The influence of anesthetic drug strategy on the incidence of post-induction hypotension in elective, non-cardiac surgery – A prospective observational cohort study Open
This study was registered in the Dutch Medical Research in Humans (OMON) register on 18 June 2019 (ID: NL7810). The study was approved by the Medical Ethics Committee of the Amsterdam UMC, location AMC, the Netherlands in December 2018 (NL…
View article: Defining Postinduction Hemodynamic Instability With an Automated Classification Model
Defining Postinduction Hemodynamic Instability With an Automated Classification Model Open
BACKGROUND: Postinduction hypotension (PIH) may be associated with increased morbidity and mortality. In earlier studies, the definition of PIH is solely based on different absolute or relative thresholds. However, the time-course (eg, how…
View article: A comparison between invasive and noninvasive measurement of the Hypotension Prediction Index
A comparison between invasive and noninvasive measurement of the Hypotension Prediction Index Open
BACKGROUND Clinical trials and validation studies demonstrate promising hypotension prediction capability by the Hypotension Prediction Index (HPI). Most studies that evaluate HPI derive it from invasive blood pressure readings, but a dire…
View article: High PEEP/low FiO2 ventilation is associated with lower mortality in COVID–19
High PEEP/low FiO2 ventilation is associated with lower mortality in COVID–19 Open
High PEEP ventilation was associated with improved ICU survival in patients with COVID-ARDS.
View article: Detecting aortic valve stenosis based on the non-invasive blood pressure waveform—a proof of concept study
Detecting aortic valve stenosis based on the non-invasive blood pressure waveform—a proof of concept study Open
The incidence of aortic valve stenosis (AoS) increases with age, and once diagnosed, symptomatic severe AoS has a yearly mortality rate of 25%. AoS is diagnosed with transthoracic echocardiography (TTE), however, this gold standard is time…
View article: Performance of a Machine Learning Algorithm to Predict Hypotension in Spontaneously Breathing Non-Ventilated Post-Anesthesia and ICU Patients
Performance of a Machine Learning Algorithm to Predict Hypotension in Spontaneously Breathing Non-Ventilated Post-Anesthesia and ICU Patients Open
Background: Hypotension is common in the post-anesthesia care unit (PACU) and intensive care unit (ICU), and is associated with adverse patient outcomes. The Hypotension Prediction Index (HPI) algorithm has been shown to accurately predict…
View article: Dynamic cerebral autoregulation during step-wise increases in blood pressure during anaesthesia
Dynamic cerebral autoregulation during step-wise increases in blood pressure during anaesthesia Open
BACKGROUND Classically, cerebral autoregulation (CA) entails cerebral blood flow (CBF) remaining constant by cerebrovascular tone adapting to fluctuations in mean arterial pressure (MAP) between ∼60 and ∼150 mmHg. However, this is not an o…
View article: Immediate reduction in left ventricular ejection time following TAVI is associated with improved quality of life
Immediate reduction in left ventricular ejection time following TAVI is associated with improved quality of life Open
Background TAVI has shown to result in immediate and sustained hemodynamic alterations and improvement in health-related quality of life (HRQoL), but previous studies have been suboptimal to predict who might benefit from TAVI. The relatio…
View article: Cardiorespiratory monitoring in the delivery room using transcutaneous electromyography
Cardiorespiratory monitoring in the delivery room using transcutaneous electromyography Open
Objective To assess feasibility of transcutaneous electromyography of the diaphragm (dEMG) as a monitoring tool for vital signs and diaphragm activity in the delivery room (DR). Design Prospective observational study. Setting Delivery room…