Eliran Arbib
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View article: 336 Significant myeloid and dendritic cellular enrichment of omidubicel graft suggests fast homeostatic proliferation of lymphoid populations
336 Significant myeloid and dendritic cellular enrichment of omidubicel graft suggests fast homeostatic proliferation of lymphoid populations Open
Background Allogeneic hematopoietic cell transplantation is a potentially curative treatment for hematologic malignancies and nonmalignant disorders. Rapid immune reconstitution (IR) following transplantation has been associated with impro…
View article: 401 GDA-201, nicotinamide (NAM) expanded NK cells derived from peripheral apheresis, show unique culture kinetics and increased expansion
401 GDA-201, nicotinamide (NAM) expanded NK cells derived from peripheral apheresis, show unique culture kinetics and increased expansion Open
Background Nicotinamide (NAM), an allosteric inhibitor of NAD-dependent enzymes, is a master regulator of NAD-related signaling pathways. Ex-vivo expansion of Natural Killer (NK) cells using Gamida-cell's proprietary nicotinamide platform …
View article: Microbiota-dependent and -independent postnatal development of salivary immunity
Microbiota-dependent and -independent postnatal development of salivary immunity Open
While saliva regulates the interplay between the microbiota and the oral immune system, the mechanisms establishing postnatal salivary immunity are ill-defined. Here, we show that high levels of neutrophils and neonatal Fc receptor (FcRn)-…
View article: S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repair
S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repair Open
The mTORC1 substrate, S6 Kinase 1 (S6K1), is involved in the regulation of cell growth, ribosome biogenesis, glucose homeostasis, and adipogenesis. Accumulating evidence has suggested a role for mTORC1 signaling in the DNA damage response.…
View article: Author response: S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repair
Author response: S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repair Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The mTORC…
View article: Systemic hypoxia inhibits T cell response by limiting mitobiogenesis via matrix substrate-level phosphorylation arrest
Systemic hypoxia inhibits T cell response by limiting mitobiogenesis via matrix substrate-level phosphorylation arrest Open
Systemic oxygen restriction (SOR) is prevalent in numerous clinical conditions, including chronic obstructive pulmonary disease (COPD), and is associated with increased susceptibility to viral infections. However, the influence of SOR on T…
View article: Author response: Systemic hypoxia inhibits T cell response by limiting mitobiogenesis via matrix substrate-level phosphorylation arrest
Author response: Systemic hypoxia inhibits T cell response by limiting mitobiogenesis via matrix substrate-level phosphorylation arrest Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Systemic oxygen restriction (SOR) is preva…
View article: Systemic hypoxia inhibits T cell response by limiting mitobiogenesis via matrix substrate-level phosphorylation arrest
Systemic hypoxia inhibits T cell response by limiting mitobiogenesis via matrix substrate-level phosphorylation arrest Open
SUMMARY Systemic oxygen restriction (SOR) is prevalent in numerous clinical conditions including chronic obstructive pulmonary disease (COPD). However, the influence of SOR on T cell protective immunity remains uncharacterized. Here we sho…