Elisa Arthofer
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View article: Class Frizzled GPCRs in GtoPdb v.2025.3
Class Frizzled GPCRs in GtoPdb v.2025.3 Open
Receptors of the Class Frizzled (FZD, nomenclature as agreed by the NC-IUPHAR subcommittee on the Class Frizzled GPCRs [184]), are GPCRs highly conserved across species and were originally identified in Drosophila [21]. While SMO shows str…
View article: Figure S3 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion
Figure S3 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion Open
Figure S3 shows that p53 loss diminishes H3K9me3 at transcriptionally upregulated repetitive elements
View article: Data from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion
Data from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion Open
Epigenetic therapies facilitate transcription of immunogenic repetitive elements that cull cancer cells through “viral mimicry” responses. Paradoxically, cancer-initiating events also facilitate transcription of repetitive elements. Contri…
View article: Table S3 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion
Table S3 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion Open
Table S3: Antibodies used in this study
View article: Figure S6 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion
Figure S6 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion Open
Figure S6 that shows Acquisition of viral mimicry tolerance affects antitumor adaptive immune responses
View article: Figure S7 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion
Figure S7 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion Open
Figure S7 that shows the impact of viral mimicry conditioning on therapeutic approaches
View article: Figure S2 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion
Figure S2 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion Open
Figure S2 shows that Trp53 mutation facilitates transcriptional dysregulation of retrotransposons in murine oviductal epithelial cells and ovarian surface epithelial cells.
View article: Table S4 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion
Table S4 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion Open
Table S4: Primer sequences used in this study
View article: Table S2 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion
Table S2 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion Open
Table S2: Guide RNAs used for CRISPR gene editing in this study
View article: Figure S4 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion
Figure S4 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion Open
Figure S4 shows that p53 loss increases cytosolic accumulation of RNA:DNA and dsRNA
View article: Figure S5 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion
Figure S5 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion Open
Figure S5 that shows Viral mimicry conditioning diminishes Type I IFN
View article: Table S1 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion
Table S1 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion Open
Table S1: Patient cohort characteristics
View article: Figure S1 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion
Figure S1 from Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion Open
Figure S1 Shows that TP53 mutation facilitates transcriptional dysregulation of retrotransposons in STICs and human fallopian tube secretory epithelial cells
View article: Class Frizzled GPCRs in GtoPdb v.2023.1
Class Frizzled GPCRs in GtoPdb v.2023.1 Open
Receptors of the Class Frizzled (FZD, nomenclature as agreed by the NC-IUPHAR subcommittee on the Class Frizzled GPCRs [180]), are GPCRs originally identified in Drosophila [20], which are highly conserved across species. While SMO shows s…
View article: Supplementary Table from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a <i>TP53</i>-Dependent Manner
Supplementary Table from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a <i>TP53</i>-Dependent Manner Open
Supplementary Table from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a TP53-Dependent Manner
View article: Supplementary Figure from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a <i>TP53</i>-Dependent Manner
Supplementary Figure from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a <i>TP53</i>-Dependent Manner Open
Supplementary Figure from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a TP53-Dependent Manner
View article: Supplementary Data from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a <i>TP53</i>-Dependent Manner
Supplementary Data from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a <i>TP53</i>-Dependent Manner Open
Supplementary Data from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a TP53-Dependent Manner
View article: Supplementary Data from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a <i>TP53</i>-Dependent Manner
Supplementary Data from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a <i>TP53</i>-Dependent Manner Open
Supplementary Data from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a TP53-Dependent Manner
View article: Supplementary Table from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a <i>TP53</i>-Dependent Manner
Supplementary Table from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a <i>TP53</i>-Dependent Manner Open
Supplementary Table from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a TP53-Dependent Manner
View article: Supplementary Data from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a <i>TP53</i>-Dependent Manner
Supplementary Data from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a <i>TP53</i>-Dependent Manner Open
Supplementary Data from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a TP53-Dependent Manner
View article: Supplementary Data from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a <i>TP53</i>-Dependent Manner
Supplementary Data from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a <i>TP53</i>-Dependent Manner Open
Supplementary Data from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a TP53-Dependent Manner
View article: Supplementary Figure from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a <i>TP53</i>-Dependent Manner
Supplementary Figure from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a <i>TP53</i>-Dependent Manner Open
Supplementary Figure from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a TP53-Dependent Manner
View article: Data from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a <i>TP53</i>-Dependent Manner
Data from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a <i>TP53</i>-Dependent Manner Open
Epithelial ovarian carcinomas are particularly deadly due to intratumoral heterogeneity, resistance to standard-of-care therapies, and poor response to alternative treatments such as immunotherapy. Targeting the ovarian carcinoma epigenome…
View article: Supplementary Data from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a <i>TP53</i>-Dependent Manner
Supplementary Data from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a <i>TP53</i>-Dependent Manner Open
Supplementary Data from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a TP53-Dependent Manner
View article: Supplementary Data from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a <i>TP53</i>-Dependent Manner
Supplementary Data from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a <i>TP53</i>-Dependent Manner Open
Supplementary Data from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a TP53-Dependent Manner
View article: Data from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a <i>TP53</i>-Dependent Manner
Data from Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a <i>TP53</i>-Dependent Manner Open
Epithelial ovarian carcinomas are particularly deadly due to intratumoral heterogeneity, resistance to standard-of-care therapies, and poor response to alternative treatments such as immunotherapy. Targeting the ovarian carcinoma epigenome…
View article: A genetically engineered, stem-cell-derived cellular vaccine
A genetically engineered, stem-cell-derived cellular vaccine Open
Despite rapid clinical translation of COVID-19 vaccines in response to the global pandemic, an opportunity remains for vaccine technology innovation to address current limitations and meet challenges of inevitable future pandemics. We desc…
View article: Inhibiting DNA methylation and RNA editing upregulates immunogenic RNA to transform the tumor microenvironment and prolong survival in ovarian cancer
Inhibiting DNA methylation and RNA editing upregulates immunogenic RNA to transform the tumor microenvironment and prolong survival in ovarian cancer Open
Background Novel therapies are urgently needed for ovarian cancer (OC), the fifth deadliest cancer in women. Preclinical work has shown that DNA methyltransferase inhibitors (DNMTis) can reverse the immunosuppressive tumor microenvironment…
View article: A Novel CRISPR-Engineered, Stem Cell-Derived Cellular Vaccine
A Novel CRISPR-Engineered, Stem Cell-Derived Cellular Vaccine Open
COVID-19 has forced rapid clinical translation of novel vaccine technologies, principally mRNA vaccines, that have resulted in meaningful efficacy and adequate safety in response to the global pandemic. Notwithstanding this success, there …
View article: Class Frizzled GPCRs in GtoPdb v.2021.3
Class Frizzled GPCRs in GtoPdb v.2021.3 Open
Receptors of the Class Frizzled (FZD, nomenclature as agreed by the NC-IUPHAR subcommittee on the Class Frizzled GPCRs [175]), are GPCRs originally identified in Drosophila [19], which are highly conserved across species. While SMO shows s…