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View article: Mitochondrial dysfunction in PRRSV-2-infected macrophages
Mitochondrial dysfunction in PRRSV-2-infected macrophages Open
Introduction Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically devastating viruses for the global swine industry. PRRSV has a known tropism for lung macrophages, where it causes impaired immune res…
View article: Establishment of Immune Biobank for Vaccine Immunogenicity Prediction Using In Vitro and In Silico Methods Against Porcine Reproductive and Respiratory Syndrome Virus
Establishment of Immune Biobank for Vaccine Immunogenicity Prediction Using In Vitro and In Silico Methods Against Porcine Reproductive and Respiratory Syndrome Virus Open
Background/Objectives: Porcine reproductive and respiratory syndrome virus (PRRSV) remains one of the most economically significant pathogens in the global swine industry. Despite the availability of commercial vaccines for over three deca…
View article: Differential Effects of Selenium Compounds on Mitochondrial Function in PRRSV-Infected Porcine Alveolar Macrophages
Differential Effects of Selenium Compounds on Mitochondrial Function in PRRSV-Infected Porcine Alveolar Macrophages Open
Selenium (Se) is a trace mineral with antioxidant and anti-inflammatory properties. Se deficiency increases oxidative stress and immunosuppression. In swine, dietary Se supplementation enhances immunity and growth, and previous studies sug…
View article: Establishment of Immune Biobank for Vaccine Immunogenicity Prediction Using <em>In Vitro</em> and <em>In Silico</em> Methods Against Porcine Reproductive and Respiratory Syndrome Virus
Establishment of Immune Biobank for Vaccine Immunogenicity Prediction Using <em>In Vitro</em> and <em>In Silico</em> Methods Against Porcine Reproductive and Respiratory Syndrome Virus Open
Background/Objectives: Porcine reproductive and respiratory syndrome virus (PRRSV) remains one of the most economically significant pathogens in the global swine industry. Despite the availability of commercial vaccines for over three deca…
View article: Defining cellular diversity at the swine maternal–fetal interface using spatial transcriptomics and organoids
Defining cellular diversity at the swine maternal–fetal interface using spatial transcriptomics and organoids Open
The placenta is a dynamic, embryo-derived organ essential for fetal growth and development. While all eutherian mammals have placentas composed of fetal-derived trophoblasts that mediate maternal–fetal exchange, their anatomical and histol…
View article: Differential Effects of Selenium Compounds on Mitochondrial Function in PRRSV-Infected Porcine Alveolar Macrophages
Differential Effects of Selenium Compounds on Mitochondrial Function in PRRSV-Infected Porcine Alveolar Macrophages Open
Selenium (Se) is an essential trace mineral with antioxidant and anti-inflammatory properties. Se deficiency increases oxidative stress and immunosuppression. In swine, dietary Se supplementation enhances immune function and growth, and pr…
View article: Challenges and Lessons Learned from a Field Trial on the Understanding of the Porcine Respiratory Disease Complex
Challenges and Lessons Learned from a Field Trial on the Understanding of the Porcine Respiratory Disease Complex Open
Background/Objectives: The porcine respiratory disease complex (PRDC) is a multifaceted, polymicrobial syndrome resulting from a combination of environmental stressors, primary infections (e.g., PRRSV) and secondary infectious agents (viru…
View article: Challenges and Lessons Learned from a Field Trial on the Understanding of the Porcine Respiratory Disease Complex
Challenges and Lessons Learned from a Field Trial on the Understanding of the Porcine Respiratory Disease Complex Open
The Porcine Respiratory Disease Complex (PRDC) is a multifaceted, polymicrobial syndrome resulting from a combination of environmental stressors, primary infections (e.g., PRRSV) and secondary infectious agents (viruses and bacteria). PRDC…
View article: Case Report: The effect of asplenia on the response to influenza vaccination and passive transfer of immunity in an adult female pig
Case Report: The effect of asplenia on the response to influenza vaccination and passive transfer of immunity in an adult female pig Open
Asplenia is an important cause of morbidity and mortality in humans. However, there are only very rare examples of this condition reported in domesticated species. Here we present a case of asplenia, diagnosed at necropsy, in a crossbred a…
View article: Prolonged airway explant culture enables study of health, disease, and viral pathogenesis
Prolonged airway explant culture enables study of health, disease, and viral pathogenesis Open
In vitro models play a major role in studying airway physiology and disease. However, the native lung's complex tissue architecture and nonepithelial cell lineages are not preserved in these models. Ex vivo tissue models could overcome in …
View article: Prolonged airway explant culture enables study of health, disease, and viral pathogenesis
Prolonged airway explant culture enables study of health, disease, and viral pathogenesis Open
In vitro models play a major role in studying airway physiology and disease. However, the native lung’s complex tissue architecture and nonepithelial cell lineages are not preserved in these models. Ex vivo tissue models could overcome in …
View article: High-throughput 96-well plate-based porcine antibody isolation protocol
High-throughput 96-well plate-based porcine antibody isolation protocol Open
For decades, scientists have used column chromatography to purify an array of analytes. The same chromatography system has also been deployed for the isolation and purification of antibodies to increase sensitivity and specificity of detec…
View article: Human long noncoding RNA <i>VILMIR</i> is induced by major respiratory viral infections and modulates the host interferon response
Human long noncoding RNA <i>VILMIR</i> is induced by major respiratory viral infections and modulates the host interferon response Open
Long noncoding RNAs (lncRNAs) are a newer class of noncoding transcripts identified as key regulators of biological processes. Here, we aimed to identify novel lncRNA targets that play critical roles in major human respiratory viral infect…
View article: Defining Cellular Diversity at the Swine Maternal-Fetal Interface Using Spatial Transcriptomics and Organoids
Defining Cellular Diversity at the Swine Maternal-Fetal Interface Using Spatial Transcriptomics and Organoids Open
The placenta is a dynamic, embryo-derived organ essential for fetal growth and development. While all eutherian mammals have placentas composed of fetal-derived trophoblasts that mediate maternal-fetal exchange, their anatomical and histol…
View article: High-throughput 96-well plate-based porcine antibody isolation protocol v1
High-throughput 96-well plate-based porcine antibody isolation protocol v1 Open
This protocol describes a modified column chromatography technique to isolate both IgG and IgA from pregnant/lactating swine to use in a variety of immunoassays. This high throughput method allows for both a rapid and consistent isotype yi…
View article: Human long noncoding RNA,<i>VILMIR,</i>is induced by major respiratory viral infections and modulates the host interferon response
Human long noncoding RNA,<i>VILMIR,</i>is induced by major respiratory viral infections and modulates the host interferon response Open
Long noncoding RNAs (lncRNAs) are a newer class of noncoding transcripts identified as key regulators of biological processes. Here we aimed to identify novel lncRNA targets that play critical roles in major human respiratory viral infecti…
View article: Prolonged airway explant culture enables study of health, disease, and viral pathogenesis
Prolonged airway explant culture enables study of health, disease, and viral pathogenesis Open
In vitro models play a major role in studying airway physiology and disease. However, the native lung’s complex tissue architecture and non-epithelial cell lineages are not preserved in these models. Ex vivo tissue models could overcome in…
View article: A rapid, high-throughput, viral infectivity assay using automated brightfield microscopy with machine learning
A rapid, high-throughput, viral infectivity assay using automated brightfield microscopy with machine learning Open
Infectivity assays are essential for the development of viral vaccines, antiviral therapies, and the manufacture of biologicals. Traditionally, these assays take 2-7 days and require several manual processing steps after infection. We desc…
View article: Testable Candidate Immune Correlates of Protection for Porcine Reproductive and Respiratory Syndrome Virus Vaccination
Testable Candidate Immune Correlates of Protection for Porcine Reproductive and Respiratory Syndrome Virus Vaccination Open
Porcine reproductive and respiratory syndrome virus (PRRSV) is an on-going problem for the worldwide pig industry. Commercial and experimental vaccinations often demonstrate reduced pathology and improved growth performance; however, speci…
View article: Effect of BIO-PLYTM, a Platelet-Rich Plasma Derived Biologic on PRRSV-2-Infected Macrophages
Effect of BIO-PLYTM, a Platelet-Rich Plasma Derived Biologic on PRRSV-2-Infected Macrophages Open
Porcine Reproductive and Respiratory Syndrome (PRRS) is the one of the most devastating diseases impacting the swine industry worldwide. Control and prevention methods rely on biosafety measures and vaccination. As an RNA virus with a high…
View article: Heterologous vaccine immunogenicity, efficacy, and immune correlates of protection of a modified-live virus porcine reproductive and respiratory syndrome virus vaccine
Heterologous vaccine immunogenicity, efficacy, and immune correlates of protection of a modified-live virus porcine reproductive and respiratory syndrome virus vaccine Open
Although porcine reproductive and respiratory syndrome virus (PRRSV) vaccines have been available in North America for almost 30 years, many vaccines face a significant hurdle: they must provide cross-protection against the highly diverse …
View article: From Open Access to Circular Health: Ilaria Capua’s Journey through Science and Politics
From Open Access to Circular Health: Ilaria Capua’s Journey through Science and Politics Open
This paper highlights the career of an exceptional woman virologist, Dr. Ilaria Capua. It recollects her major achievements, awards and noteworthy events that have shaped her scientific and political career. It retraces Dr. Capua’s major c…
View article: The health benefits of selenium in food animals: a review
The health benefits of selenium in food animals: a review Open
Selenium is an essential trace mineral important for the maintenance of homeostasis in animals and humans. It evinces a strong antioxidant, anti-inflammatory and potential antimicrobial capacity. Selenium biological function is primarily a…
View article: A Rapid, High Throughput, Viral Infectivity Assay using Automated Brightfield Microscopy with Machine Learning
A Rapid, High Throughput, Viral Infectivity Assay using Automated Brightfield Microscopy with Machine Learning Open
Infectivity assays are essential for the development of viral vaccines, antiviral therapies and the manufacture of biologicals. Traditionally, these assays take 2–7 days and require several manual processing steps after infection. We descr…
View article: A Liquid Metal Mediated Metallic Coating for Antimicrobial and Antiviral Fabrics (Adv. Mater. 45/2021)
A Liquid Metal Mediated Metallic Coating for Antimicrobial and Antiviral Fabrics (Adv. Mater. 45/2021) Open
Antiviral Coatings During the COVID-19 pandemic, robust and effective antimicrobial and antiviral fabrics have been required. In article 2104298, Michael D. Dickey, Vi Khanh Truong, Tae-il Kim, and co-workers propose an easy-to-control and…
View article: Corrigendum: Complement-Opsonized HIV Modulates Pathways Involved in Infection of Cervical Mucosal Tissues: A Transcriptomic and Proteomic Study
Corrigendum: Complement-Opsonized HIV Modulates Pathways Involved in Infection of Cervical Mucosal Tissues: A Transcriptomic and Proteomic Study Open
CORRECTION article Front. Immunol., 08 July 2021Sec. Viral Immunology Volume 12 - 2021 | https://doi.org/10.3389/fimmu.2021.730130
View article: Whole Genome or Single Genes? A Phylodynamic and Bibliometric Analysis of PRRSV
Whole Genome or Single Genes? A Phylodynamic and Bibliometric Analysis of PRRSV Open
Diversity, ecology, and evolution of viruses are commonly determined through phylogenetics, an accurate tool for the identification and study of lineages with different pathological characteristics within the same species. In the case of P…
View article: Complement-Opsonized HIV Modulates Pathways Involved in Infection of Cervical Mucosal Tissues: A Transcriptomic and Proteomic Study
Complement-Opsonized HIV Modulates Pathways Involved in Infection of Cervical Mucosal Tissues: A Transcriptomic and Proteomic Study Open
Genital mucosal transmission is the most common route of HIV spread. The initial responses triggered at the site of viral entry are reportedly affected by host factors, especially complement components present at the site, and this will ha…
View article: The Local and Systemic Humoral Immune Response Against Homologous and Heterologous Strains of the Type 2 Porcine Reproductive and Respiratory Syndrome Virus
The Local and Systemic Humoral Immune Response Against Homologous and Heterologous Strains of the Type 2 Porcine Reproductive and Respiratory Syndrome Virus Open
The humoral immune response plays a crucial role in the combat and protection against many pathogens including the economically most important, highly prevalent, and diverse pig pathogen PRRSV – the Porcine Reproductive and Respiratory Syn…
View article: Maternal Autogenous Inactivated Virus Vaccination Boosts Immunity to PRRSV in Piglets
Maternal Autogenous Inactivated Virus Vaccination Boosts Immunity to PRRSV in Piglets Open
Maternal-derived immunity is a critical component for the survival and success of offspring in pigs to protect from circulating pathogens such as Type 2 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV-2). The purpose of this stu…