Elisa Enriquez-Hesles
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View article: Increased alcohol dehydrogenase 1 activity promotes longevity
Increased alcohol dehydrogenase 1 activity promotes longevity Open
View article: Chronological lifespan extension and nucleotide salvage inhibition in yeast by isonicotinamide supplementation
Chronological lifespan extension and nucleotide salvage inhibition in yeast by isonicotinamide supplementation Open
Isonicotinamide (INAM) is an isomer of the NAD + precursor nicotinamide (NAM) that stimulates the enzymatic activity of Sir2, an NAD + -dependent histone deacetylase from the budding yeast, Saccharomyces cerevisiae . Supplementing INAM int…
View article: A cell-nonautonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism
A cell-nonautonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism Open
Caloric restriction (CR) improves health span and life span of organisms ranging from yeast to mammals. Understanding the mechanisms involved will uncover future interventions for aging-associated diseases. In budding yeast, Saccharomyces …
View article: A cell non-autonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism
A cell non-autonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism Open
Caloric restriction (CR) improves healthspan and lifespan of organisms ranging from yeast to mammals. Understanding the mechanisms involved will uncover future interventions for aging associated diseases. In budding yeast, Saccharomyces ce…
View article: Managing Cancer Cachexia: Multi-Disciplinary Healthcare Perspectives
Managing Cancer Cachexia: Multi-Disciplinary Healthcare Perspectives Open
BackgroundCachexia is a syndrome which is a common feature in more than 80% of patients with advanced cancer and globally accounts for over two million deaths per annum.At present there are no standard treatment guidelines for cancer cache…
View article: Spontaneous mutations in CYC8 and MIG1 suppress the short chronological lifespan of budding yeast lacking SNF1/AMPK
Spontaneous mutations in CYC8 and MIG1 suppress the short chronological lifespan of budding yeast lacking SNF1/AMPK Open
Chronologically aging yeast cells are prone to adaptive regrowth, whereby mutants with a survival advantage spontaneously appear and re-enter the cell cycle in stationary phase cultures. Adaptive regrowth is especially noticeable with shor…
View article: Epigenetics of cancer-associated muscle catabolism
Epigenetics of cancer-associated muscle catabolism Open
Cancer patients are commonly affected by cachexia, a wasting process involving muscle and fat. Specifically, loss of the muscle compartment has been associated with poor prognosis and suboptimal response to therapy. Nutritional support has…
View article: Nuclear Factor of Activated T Cells-dependent Down-regulation of the Transcription Factor Glioma-associated Protein 1 (GLI1) Underlies the Growth Inhibitory Properties of Arachidonic Acid
Nuclear Factor of Activated T Cells-dependent Down-regulation of the Transcription Factor Glioma-associated Protein 1 (GLI1) Underlies the Growth Inhibitory Properties of Arachidonic Acid Open