Elisa Gardiman
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View article: Neutrophils Display Novel Partners of Cytosolic Proliferating Cell Nuclear Antigen Involved in Interferon Response in COVID-19 Patients
Neutrophils Display Novel Partners of Cytosolic Proliferating Cell Nuclear Antigen Involved in Interferon Response in COVID-19 Patients Open
Introduction: Neutrophils are key players in the hyperinflammatory response during SARS-CoV-2 infection. The cytosolic proliferating cell nuclear antigen (PCNA) is a scaffolding protein highly dependent on the microenvironment status and k…
View article: Uncovering two neutrophil-committed progenitors that immediately precede promyelocytes during human neutropoiesis
Uncovering two neutrophil-committed progenitors that immediately precede promyelocytes during human neutropoiesis Open
Technological advances have greatly improved our knowledge of myelopoiesis, for example, with the discovery of granulocyte‒monocyte‒dendritic cell (DC) progenitors (GMDPs), monocyte‒DC progenitors (MDPs), common DC progenitors (CDPs) and c…
View article: Surface CD52, CD84, and PTGER2 mark mature PMN-MDSCs from cancer patients and G-CSF-treated donors
Surface CD52, CD84, and PTGER2 mark mature PMN-MDSCs from cancer patients and G-CSF-treated donors Open
Precise molecular characterization of circulating polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) is hampered by their mixed composition of mature and immature cells and lack of specific markers. Here, we focus on mature CD6…
View article: The slan antigen identifies the prototypical non-classical CD16+-monocytes in human blood
The slan antigen identifies the prototypical non-classical CD16+-monocytes in human blood Open
Introduction Peripheral monocytes in humans are conventionally divided into classical (CL, CD14 ++ CD16 − ), intermediate (INT, CD14 ++ CD16 + ) and non-classical (NC, CD14 dim/− CD16 ++ ) cells, based on their expression levels of CD14 an…
View article: Clinical and transcriptomic characteristics of a novel SMARCD2 mutation that disrupts neutrophil maturation and function
Clinical and transcriptomic characteristics of a novel SMARCD2 mutation that disrupts neutrophil maturation and function Open
We report a novel case of SMARCD2 (SWI/SNF‐related, matrix‐associated, actin‐dependent regulator of chromatin, subfamily D, member 2) mutation successfully treated with hematopoietic stem cell transplantation. The female patient presented …
View article: CD14+-Monocytes Exposed to Apolipoprotein CIII Express Tissue Factor
CD14+-Monocytes Exposed to Apolipoprotein CIII Express Tissue Factor Open
Apolipoprotein CIII (ApoCIII) represents a key regulator of plasma lipid metabolism and a recognized risk factor for atherosclerosis and cardiovascular diseases. Beyond the regulation of lipoprotein trafficking, ApoCIII is also involved in…
View article: SARS-CoV-2-Associated ssRNAs Activate Human Neutrophils in a TLR8-Dependent Fashion
SARS-CoV-2-Associated ssRNAs Activate Human Neutrophils in a TLR8-Dependent Fashion Open
COVID-19 disease is characterized by a dysregulation of the innate arm of the immune system. However, the mechanisms whereby innate immune cells, including neutrophils, become activated in patients are not completely understood. Recently, …
View article: Tumor‐associated neutrophils (TANs) in human carcinoma‐draining lymph nodes: a novel TAN compartment
Tumor‐associated neutrophils (TANs) in human carcinoma‐draining lymph nodes: a novel TAN compartment Open
Objectives The role of tumor‐associated neutrophils (TANs) in the nodal spread of cancer cells remains unexplored. The present study evaluates the occurrence and clinical significance of human nodal TANs. Methods The relevance, derivation,…
View article: Deciphering the fate of slan <sup>+</sup> ‐monocytes in human tonsils by gene expression profiling
Deciphering the fate of slan <sup>+</sup> ‐monocytes in human tonsils by gene expression profiling Open
Monocytic cells perform crucial homeostatic and defensive functions. However, their fate and characterization at the transcriptomic level in human tissues are partially understood, often as a consequence of the lack of specific markers all…
View article: Multisystem autoimmune disease caused by increased STAT3 phosphorylation and dysregulated gene expression
Multisystem autoimmune disease caused by increased STAT3 phosphorylation and dysregulated gene expression Open
Signal transducer and activator of transcription (STAT) 3 is a member of the STAT family, and plays a major role in various immunological mechanisms.[1][1] Mutations in STAT3 are associated with a broad spectrum of manifestations, includin…
View article: Cytokine production by human neutrophils: Revisiting the “dark side of the moon”
Cytokine production by human neutrophils: Revisiting the “dark side of the moon” Open
Polymorphonuclear neutrophils are the most numerous leucocytes present in human blood, and function as crucial players in innate immune responses. Neutrophils are indispensable for the defence towards microbes, as they effectively counter …
View article: A Reappraisal on the Potential Ability of Human Neutrophils to Express and Produce IL-17 Family Members In Vitro: Failure to Reproducibly Detect It
A Reappraisal on the Potential Ability of Human Neutrophils to Express and Produce IL-17 Family Members In Vitro: Failure to Reproducibly Detect It Open
Neutrophils are known to perform a series of effector functions that are crucial for the innate and adaptive responses, including the synthesis and secretion of a variety of cytokines. In light of the controversial data in the literature, …