Elisa Greggio
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View article: LRRK2 and the fragile synapse: a molecular prelude to Parkinson’s disease?
LRRK2 and the fragile synapse: a molecular prelude to Parkinson’s disease? Open
Parkinson’s disease (PD) is a multisystem disorder presenting motor and non-motor symptoms. Motor dysfunction is the most debilitating, caused by the degeneration of dopamine-producing neurons. Increasing evidence indicates that synapse de…
View article: LRRK2 regulates synaptic function through modulation of actin cytoskeletal dynamics
LRRK2 regulates synaptic function through modulation of actin cytoskeletal dynamics Open
Parkinson’s disease (PD) is a multisystemic disorder that manifests through motor and non-motor symptoms. Motor dysfunction is the most debilitating and it is caused by the degeneration of dopamine-producing neurons in the substantia nigra…
View article: Author response: LRRK2 regulates synaptic function through modulation of actin cytoskeletal dynamics
Author response: LRRK2 regulates synaptic function through modulation of actin cytoskeletal dynamics Open
View article: Leucine-rich repeat kinase 2 impairs the release sites of Parkinson's disease vulnerable dopamine axons
Leucine-rich repeat kinase 2 impairs the release sites of Parkinson's disease vulnerable dopamine axons Open
The end-stage pathology of Parkinson's disease (PD) involves the loss of dopamine-producing neurons in the substantia nigra pars compacta (SNc). However, synaptic deregulation of these neurons begins much earlier. Understanding the mechani…
View article: Leucine-rich repeat kinase 2 impairs the release sites of Parkinson's disease vulnerable dopamine axons
Leucine-rich repeat kinase 2 impairs the release sites of Parkinson's disease vulnerable dopamine axons Open
The end-stage pathology of Parkinson's disease (PD) involves the loss of dopamine-producing neurons in the substantia nigra pars compacta (SNc). However, synaptic deregulation of these neurons begins much earlier. Understanding the mechani…
View article: Nuclear ASC speck formation in microglia is associated with inflammasome priming and is exacerbated in LRRK2-G2019S Parkinson’s disease
Nuclear ASC speck formation in microglia is associated with inflammasome priming and is exacerbated in LRRK2-G2019S Parkinson’s disease Open
Neuroinflammation is increasingly recognized as a central pathological mechanism in Parkinson’s disease (PD), a progressive neurodegenerative disorder characterized by the selective loss of dopaminergic neurons and variety of motor and non…
View article: Developing nanobodies as allosteric molecular chaperones of glucocerebrosidase function
Developing nanobodies as allosteric molecular chaperones of glucocerebrosidase function Open
View article: LRRK2 mediates haloperidol-induced changes in indirect pathway striatal projection neurons
LRRK2 mediates haloperidol-induced changes in indirect pathway striatal projection neurons Open
Haloperidol is used to manage psychotic symptoms in several neurological disorders through mechanisms that involve antagonism of dopamine D2 receptors that are highly expressed in the striatum. Significant side effects of haloperidol, know…
View article: PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific manner
PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific manner Open
View article: Sequestosome-1 (SQSTM1/p62) as a target in dopamine catabolite-mediated cellular dyshomeostasis
Sequestosome-1 (SQSTM1/p62) as a target in dopamine catabolite-mediated cellular dyshomeostasis Open
View article: LRRK2 mediates haloperidol-induced changes in indirect pathway striatal projection neurons
LRRK2 mediates haloperidol-induced changes in indirect pathway striatal projection neurons Open
Haloperidol is used to manage psychotic symptoms in several neurological disorders through mechanisms that involve antagonism of dopamine D2 receptors that are highly expressed in the striatum. Significant side effects of haloperidol, know…
View article: PAK6 promotes neuronal autophagy by regulating TFEB nuclear translocation.
PAK6 promotes neuronal autophagy by regulating TFEB nuclear translocation. Open
Autophagy is a highly conserved homeostatic process essential for the bulk degradation of cytoplasmic components and aggregated proteins. Multiple evidence indicates that impairment of (macro)autophagy leads to neurodegeneration, such as P…
View article: PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific manner
PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific manner Open
P21 activated kinase 6 (PAK6) is a serine-threonine kinase with physiological expression enriched in the brain and overexpressed in a number of human tumors. While the role of PAK6 in cancer cells has been extensively investigated, the phy…
View article: PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific manner
PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific manner Open
P21 activated kinase 6 (PAK6) is a serine-threonine kinase with physiological expression enriched in the brain and overexpressed in a number of human tumors. While the role of PAK6 in cancer cells has been extensively investigated, the phy…
View article: Prospective Role of PAK6 and 14-3-3γ as Biomarkers for Parkinson’s Disease
Prospective Role of PAK6 and 14-3-3γ as Biomarkers for Parkinson’s Disease Open
Background: Parkinson’s disease is a progressive neurodegenerative disorder mainly distinguished by sporadic etiology, although a genetic component is also well established. Variants in the LRRK2 gene are associated with both familiar and …
View article: LRRK2 regulates synaptic function through modulation of actin cytoskeletal dynamics
LRRK2 regulates synaptic function through modulation of actin cytoskeletal dynamics Open
Parkinson’s disease (PD) is a multisystemic disorder that manifests through motor and non-motor symptoms. Motor dysfunction is the most debilitating and it is caused by the degeneration of dopamine-producing neurons in the substantia nigra…
View article: Reviewer #1 (Public Review): LRRK2 regulates synaptic function through BDNF signaling and actin cytoskeleton
Reviewer #1 (Public Review): LRRK2 regulates synaptic function through BDNF signaling and actin cytoskeleton Open
Parkinson's disease (PD) is a multisystemic disorder that manifests through motor and non-motor symptoms. Motor dysfunction is the most debilitating and it is caused by the degeneration of dopamine-producing neurons in the substantia nigra…
View article: Reviewer #2 (Public Review): LRRK2 regulates synaptic function through BDNF signaling and actin cytoskeleton
Reviewer #2 (Public Review): LRRK2 regulates synaptic function through BDNF signaling and actin cytoskeleton Open
Parkinson's disease (PD) is a multisystemic disorder that manifests through motor and non-motor symptoms. Motor dysfunction is the most debilitating and it is caused by the degeneration of dopamine-producing neurons in the substantia nigra…
View article: LRRK2 regulates synaptic function through BDNF signaling and actin cytoskeleton
LRRK2 regulates synaptic function through BDNF signaling and actin cytoskeleton Open
Parkinson’s disease (PD) is a multisystemic disorder that manifests through motor and non-motor symptoms. Motor dysfunction is the most debilitating and it is caused by the degeneration of dopamine-producing neurons in the substantia nigra…
View article: Identification and characterization of nanobodies acting as molecular chaperones for glucocerebrosidase through a novel allosteric mechanism
Identification and characterization of nanobodies acting as molecular chaperones for glucocerebrosidase through a novel allosteric mechanism Open
The enzyme glucocerebrosidase (GCase) catalyses the hydrolysis of glucosylceramide to glucose and ceramide within lysosomes. Homozygous or compound heterozygous mutations in the GCase-sencoding GBA1 gene cause the lysosomal storage disorde…
View article: Investigation of microglial diversity in a LRRK2 G2019S mouse model of Parkinson's disease
Investigation of microglial diversity in a LRRK2 G2019S mouse model of Parkinson's disease Open
View article: Correction: Human frataxin, the Friedreich ataxia deficient protein, interacts with mitochondrial respiratory chain
Correction: Human frataxin, the Friedreich ataxia deficient protein, interacts with mitochondrial respiratory chain Open
View article: PAK6-mediated phosphorylation of PPP2R2C regulates LRRK2-PP2A complex formation
PAK6-mediated phosphorylation of PPP2R2C regulates LRRK2-PP2A complex formation Open
Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of inherited and sporadic Parkinson’s disease (PD) and previous work suggests that dephosphorylation of LRRK2 at a cluster of heterologous phosphosites is associated to d…
View article: Human frataxin, the Friedreich ataxia deficient protein, interacts with mitochondrial respiratory chain
Human frataxin, the Friedreich ataxia deficient protein, interacts with mitochondrial respiratory chain Open
View article: Investigation of microglial diversity in a mouse model of Parkinson’s disease pathology
Investigation of microglial diversity in a mouse model of Parkinson’s disease pathology Open
Microglia, the central nervous system resident immune cells, are now recognized to critically impact homeostasis maintenance and contribute to the outcomes of various pathological conditions including Parkinson’s disease (PD). Microglia ar…
View article: Prospective role of PAK6 and 14-3-3γ as biomarkers for Parkinson’s disease
Prospective role of PAK6 and 14-3-3γ as biomarkers for Parkinson’s disease Open
Parkinson’s disease (PD) is a progressive neurodegenerative disorder mainly distinguished by sporadic aetiology, although a genetic component is also well established. Variants in the LRRK2 gene are associated with both familiar and sporad…
View article: Inhibition of the Exocyst Complex Attenuates the LRRK2 Pathological Effects
Inhibition of the Exocyst Complex Attenuates the LRRK2 Pathological Effects Open
Pathological mutations in leucine-rich repeat kinase 2 (LRRK2) gene are the major genetic cause of Parkinson’s disease (PD). Multiple lines of evidence link LRRK2 to the control of vesicle dynamics through phosphorylation of a subset of RA…
View article: Prospective role of PAK6 and 14-3-3γ as biomarkers for Parkinson’s disease
Prospective role of PAK6 and 14-3-3γ as biomarkers for Parkinson’s disease Open
2. Abstract Background Parkinson’s disease is a progressive neurodegenerative disorder mainly distinguished by sporadic aetiology, although a genetic component is also well established. Variants in the LRRK2 gene are associated with both f…
View article: DOPAL initiates αSynuclein-dependent impaired proteostasis and degeneration of neuronal projections in Parkinson’s disease
DOPAL initiates αSynuclein-dependent impaired proteostasis and degeneration of neuronal projections in Parkinson’s disease Open
View article: DJ-1 promotes energy balance by regulating both mitochondrial and autophagic homeostasis
DJ-1 promotes energy balance by regulating both mitochondrial and autophagic homeostasis Open
The protein DJ-1 is mutated in rare familial forms of recessive Parkinson's disease and in parkinsonism accompanied by amyotrophic lateral sclerosis symptoms and dementia. DJ-1 is considered a multitasking protein able to confer protection…