Elisa Kreibich
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View article: Mouse promoters are characterised by low occupancy and high turnover of RNA polymerase II
Mouse promoters are characterised by low occupancy and high turnover of RNA polymerase II Open
The general transcription machinery and its occupancy at promoters are highly conserved across metazoans. This contrasts with the kinetics of mRNA production that considerably differ between model species such as Drosophila and mouse. The …
View article: Relevance of <scp>DNA</scp> methylation at enhancers for the acquisition of cell identities
Relevance of <span>DNA</span> methylation at enhancers for the acquisition of cell identities Open
DNA methylation (5mC) is an essential epigenetic mark associated with transcriptional silencing. The role of 5mC in transcriptional repression is well established for a few hundred genes through methylation of their promoters. Yet, whether…
View article: Single-molecule footprinting identifies context-dependent regulation of enhancers by DNA methylation
Single-molecule footprinting identifies context-dependent regulation of enhancers by DNA methylation Open
Enhancers are cis-regulatory elements that control the establishment of cell identities during development. In mammals, enhancer activation is tightly coupled with DNA demethylation. However, whether this epigenetic remodeling is necessary…
View article: Single molecule multi-omics reveals context-dependent regulation of enhancers by DNA methylation
Single molecule multi-omics reveals context-dependent regulation of enhancers by DNA methylation Open
Enhancers are cis -regulatory elements that control the establishment of cell identities during development. In mammals, enhancer activation is tightly coupled with local DNA demethylation. Yet, whether this epigenetic remodelling is neces…
View article: IMPLICON: an ultra-deep sequencing method to uncover DNA methylation at imprinted regions
IMPLICON: an ultra-deep sequencing method to uncover DNA methylation at imprinted regions Open
Genomic imprinting is an epigenetic phenomenon leading to parental allele-specific expression. Dosage of imprinted genes is crucial for normal development and its dysregulation accounts for several human disorders. This unusual expression …
View article: IMPLICON: an ultra-deep sequencing method to uncover DNA methylation at imprinted regions
IMPLICON: an ultra-deep sequencing method to uncover DNA methylation at imprinted regions Open
Genomic imprinting is an epigenetic phenomenon leading to parental allele-specific expression. Dosage of imprinted genes is crucial for normal development and its dysregulation accounts for several human disorders. This unusual expression …
View article: Dppa2 and Dppa4 directly regulate the Dux-driven zygotic transcriptional program
Dppa2 and Dppa4 directly regulate the Dux-driven zygotic transcriptional program Open
The molecular regulation of zygotic genome activation (ZGA) in mammals remains an exciting area of research. Primed mouse embryonic stem cells contain a rare subset of “2C-like” cells that are epigenetically and transcriptionally similar t…
View article: Dppa2 and Dppa4 directly regulate the Dux driven zygotic transcriptional programme
Dppa2 and Dppa4 directly regulate the Dux driven zygotic transcriptional programme Open
The molecular regulation of zygotic genome activation (ZGA) in mammals remains poorly understood. Primed mouse embryonic stem cells contain a rare subset of “2C-like” cells that are epigenetically and transcriptionally similar to the two c…
View article: Split-BioID a conditional proteomics approach to monitor the composition of spatiotemporally defined protein complexes
Split-BioID a conditional proteomics approach to monitor the composition of spatiotemporally defined protein complexes Open