Elisa Nerli
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View article: Spatiotemporal Coordination of Guidance Cues Directs Multipolar Migration During Retinal Lamination
Spatiotemporal Coordination of Guidance Cues Directs Multipolar Migration During Retinal Lamination Open
Summary Multipolar migration is a conserved neuronal migration mode in the developing brain, enabling emerging neurons to navigate crowded environments and reach precise laminar positions. Yet how these cells interpret external cues to gui…
View article: GEQO biosensors for absolute analyte quantification in single cells
GEQO biosensors for absolute analyte quantification in single cells Open
Genetically encoded fluorescent biosensors are widely used to monitor small molecule and ion levels in living cells. Quantitative FRET and FLIM sensors and highly sensitive intensiometric sensors have been developed for many analytes. Notw…
View article: Injury-induced electrochemical coupling triggers regenerative cell proliferation
Injury-induced electrochemical coupling triggers regenerative cell proliferation Open
Organ injury triggers non-neuronal electric currents essential for regeneration. Yet, the mechanisms by which electrical signals are generated, sensed and transmitted upon damage to promote organ growth remain unclear. Here, we uncover tha…
View article: Deterministic and probabilistic fate decisions co-exist in a single retinal lineage
Deterministic and probabilistic fate decisions co-exist in a single retinal lineage Open
Summary Correct nervous system development depends on the timely differentiation of progenitor cells into neurons. While the output of progenitor differentiation is well investigated at the population and clonal level, the possibilities an…
View article: Bidirectional neuronal migration coordinates retinal morphogenesis by preventing spatial competition
Bidirectional neuronal migration coordinates retinal morphogenesis by preventing spatial competition Open
While the design of industrial products is often optimized for the sequential assembly of single components, organismal development is hallmarked by the concomitant occurrence of tissue growth and organization. Often this means that prolif…
View article: Asymmetric neurogenic commitment of retinal progenitors involves Notch through the endocytic pathway
Asymmetric neurogenic commitment of retinal progenitors involves Notch through the endocytic pathway Open
During brain development, progenitor cells need to balanceproliferation and differentiation in order to generate different neurons in the correct numbers and proportions. Currently, the patterns of multipotent progenitor divisions that lea…
View article: Author response: Asymmetric neurogenic commitment of retinal progenitors involves Notch through the endocytic pathway
Author response: Asymmetric neurogenic commitment of retinal progenitors involves Notch through the endocytic pathway Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract During brain development, progenitor cells…
View article: Stochasticity and determinism in cell fate decisions
Stochasticity and determinism in cell fate decisions Open
During development, cells need to make decisions about their fate in order to ensure that the correct numbers and types of cells are established at the correct time and place in the embryo. Such cell fate decisions are often classified as …
View article: Asymmetric neurogenic commitment of retinal progenitors is regulated via the Notch endocytic pathway
Asymmetric neurogenic commitment of retinal progenitors is regulated via the Notch endocytic pathway Open
During brain development, progenitor cells need to balance proliferation and differentiation in order to generate different neurons in the correct numbers and proportions. Currently, the patterns of multipotent progenitors’ division that l…