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View article: Gold Tripyrrindione: Redox Chemistry and Reactivity with Dichloromethane
Gold Tripyrrindione: Redox Chemistry and Reactivity with Dichloromethane Open
The identification of ligands that stabilize Au(III) centers has led to the isolation of complexes for applications in catalysis, gold-based therapeutics, and functional materials. Herein, we report the coordination of gold by tripyrrin-1,…
View article: Temperature-Dependent Spin-Driven Dimerization Determines the Ultrafast Dynamics of a Copper(II)-Bound Tripyrrindione Radical
Temperature-Dependent Spin-Driven Dimerization Determines the Ultrafast Dynamics of a Copper(II)-Bound Tripyrrindione Radical Open
Radicals and other open-shell molecules play a central role in chemical transformations and redox chemistry. While radicals are often highly reactive, stable radical systems are desirable for a range of potential applications ranging from …
View article: Design of Tetrazolium Cations for the Release of Antiproliferative Formazan Chelators in Mammalian Cells
Design of Tetrazolium Cations for the Release of Antiproliferative Formazan Chelators in Mammalian Cells Open
Cancer cells generally present a higher demand for iron, which plays crucial roles in tumor progression and metastasis. This iron addiction provides opportunities to develop broad spectrum anticancer drugs that target iron metabolism. In t…
View article: CCDC 2182028: Experimental Crystal Structure Determination
CCDC 2182028: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2182027: Experimental Crystal Structure Determination
CCDC 2182027: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2182029: Experimental Crystal Structure Determination
CCDC 2182029: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2182030: Experimental Crystal Structure Determination
CCDC 2182030: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Multicenter interactions and ligand field effects in platinum(II) tripyrrindione radicals
Multicenter interactions and ligand field effects in platinum(II) tripyrrindione radicals Open
The tripyrrin-1,14-dione biopyrrin, which shares the scaffold of several naturally occurring heme metabolites, is a redox-active platform for metal coordination. We report the synthesis of square planar platinum(II) tripyrrindiones, in whi…
View article: Thiol-Reactive Arylsulfonate Masks for Phenolate Donors in Antiproliferative Iron Prochelators
Thiol-Reactive Arylsulfonate Masks for Phenolate Donors in Antiproliferative Iron Prochelators Open
Tridentate thiosemicarbazones, among several families of iron chelators, have shown promising results in anticancer drug discovery because they target the increased need for iron that characterizes malignant cells. Prochelation strategies,…
View article: Aroylhydrazone Glycoconjugate Prochelators Exploit Glucose Transporter 1 (GLUT1) to Target Iron in Cancer Cells
Aroylhydrazone Glycoconjugate Prochelators Exploit Glucose Transporter 1 (GLUT1) to Target Iron in Cancer Cells Open
Glycoconjugation strategies in anticancer drug discovery exploit the high expression of glucose transporters in malignant cells to achieve preferential uptake and hence attractive pharmacological characteristics of increased therapeutic wi…
View article: CCDC 2060902: Experimental Crystal Structure Determination
CCDC 2060902: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2060901: Experimental Crystal Structure Determination
CCDC 2060901: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Time-Resolved Dynamics of Stable Open- and Closed-Shell Neutral Radical and Oxidized Tripyrrindione Complexes
Time-Resolved Dynamics of Stable Open- and Closed-Shell Neutral Radical and Oxidized Tripyrrindione Complexes Open
Stable open- and closed-shell Pd(II) and Cu(II) complexes of hexaethyl tripyrrin-1,14-dione (TD1) produce triplet, doublet or singlet states depending on the metal center and the redox state of the ligand. Pd(II) and Cu(II) form neutral TD…
View article: Front Cover: Albumin Conjugates of Thiosemicarbazone and Imidazole‐2‐thione Prochelators: Iron Coordination and Antiproliferative Activity (ChemMedChem 18/2021)
Front Cover: Albumin Conjugates of Thiosemicarbazone and Imidazole‐2‐thione Prochelators: Iron Coordination and Antiproliferative Activity (ChemMedChem 18/2021) Open
The Front Cover shows the bioconjugation of an antiproliferative prochelator to serum albumin via formation of a disulfide bond with a reduced cysteine on the protein. The abundance of albumin in blood is represented by the red background …
View article: Ligand-Centered Triplet Diradical Supported by a Binuclear Palladium(II) Dipyrrindione
Ligand-Centered Triplet Diradical Supported by a Binuclear Palladium(II) Dipyrrindione Open
Oligopyrroles form a versatile class of redox-active ligands and electron reservoirs. Although the stabilization of radicals within oligopyrrolic π systems is more common for macrocyclic ligands, bidentate dipyrrindiones are emerging as co…
View article: Stabilization of a Triplet Diradical on a Binuclear palladium(II) Dipyrrindione
Stabilization of a Triplet Diradical on a Binuclear palladium(II) Dipyrrindione Open
Porphyrins and other macrocyclic oligopyrroles form a versatile class of redox-active ligands and electron reservoirs. The stabilization of unpaired electrons within oligopyrrolic π systems adds to the available reactivity pathways and spi…
View article: Stabilization of a Triplet Diradical on a Binuclear palladium(II) Dipyrrindione
Stabilization of a Triplet Diradical on a Binuclear palladium(II) Dipyrrindione Open
Porphyrins and other macrocyclic oligopyrroles form a versatile class of redox-active ligands and electron reservoirs. The stabilization of unpaired electrons within oligopyrrolic π systems adds to the available reactivity pathways and spi…
View article: Iron Chelator Transmetalative Approach to Inhibit Human Ribonucleotide Reductase
Iron Chelator Transmetalative Approach to Inhibit Human Ribonucleotide Reductase Open
Efforts directed at curtailing the bioavailability of intracellular iron could lead to the development of broad-spectrum anticancer drugs given the metal's role in cancer proliferation and metastasis. Human ribonucleotide reductase (RNR), …
View article: Albumin Conjugates of Thiosemicarbazone and Imidazole‐2‐thione Prochelators: Iron Coordination and Antiproliferative Activity
Albumin Conjugates of Thiosemicarbazone and Imidazole‐2‐thione Prochelators: Iron Coordination and Antiproliferative Activity Open
The central role of iron in tumor progression and metastasis motivates the development of iron‐binding approaches in cancer chemotherapy. Disulfide‐based prochelators are reductively activated upon cellular uptake to liberate thiol chelato…
View article: Iron Complexes of an Antiproliferative Aroyl Hydrazone: Characterization of Three Protonation States by Electron Paramagnetic Resonance Methods
Iron Complexes of an Antiproliferative Aroyl Hydrazone: Characterization of Three Protonation States by Electron Paramagnetic Resonance Methods Open
Tridentate aroyl hydrazones are effective metal chelators in biological settings, and their activity has been investigated extensively for medicinal applications in metal overload, cancer, and neurodegenerative diseases. The aroyl hydrazon…
View article: The Disturbed Iron Phenotype of Tumor Cells and Macrophages in Renal Cell Carcinoma Influences Tumor Growth
The Disturbed Iron Phenotype of Tumor Cells and Macrophages in Renal Cell Carcinoma Influences Tumor Growth Open
Accumulating evidence suggests that iron homeostasis is disturbed in tumors. We aimed at clarifying the distribution of iron in renal cell carcinoma (RCC). Considering the pivotal role of macrophages for iron homeostasis and their associat…
View article: Iron as a Central Player and Promising Target in Cancer Progression
Iron as a Central Player and Promising Target in Cancer Progression Open
Iron is an essential element for virtually all organisms. On the one hand, it facilitates cell proliferation and growth. On the other hand, iron may be detrimental due to its redox abilities, thereby contributing to free radical formation,…