Elisabeth Ableitner
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View article: Adipose Triglyceride Lipase Knockout Increases Anticontractile Effects of Perivascular Adipose Tissue
Adipose Triglyceride Lipase Knockout Increases Anticontractile Effects of Perivascular Adipose Tissue Open
BACKGROUND: Perivascular adipose tissue (PVAT) fine-tunes blood vessel contractility and vascular homeostasis. During obesity and atherosclerosis, PVAT becomes dysfunctional and loses its anticontractile potential. Previously, we reported …
View article: Mitochondrial ROS drive foam cell formation via STAT5 signaling in atherosclerosis
Mitochondrial ROS drive foam cell formation via STAT5 signaling in atherosclerosis Open
Macrophage-to-foam cell transition is an integral part of atherosclerotic plaque progression. Particularly, oxidized low-density lipoprotein (oxLDL) is a driving factor in foam cell formation, altering macrophage function and metabolism. T…
View article: An autocrine synergistic desmin-SPARC network promotes cardiomyogenesis in cardiac stem cells
An autocrine synergistic desmin-SPARC network promotes cardiomyogenesis in cardiac stem cells Open
The mammalian heart contains cardiac stem cells throughout life, but it has not been possible to harness or stimulate these cells to repair damaged myocardium in vivo. Assuming physiological relevance of these cells, which have evolved and…
View article: Effects of Chronic Inflammatory Activation of Murine and Human Arterial Endothelial Cells at Normal Lipoprotein and Cholesterol Levels In Vivo and In Vitro
Effects of Chronic Inflammatory Activation of Murine and Human Arterial Endothelial Cells at Normal Lipoprotein and Cholesterol Levels In Vivo and In Vitro Open
The activation of endothelial cells is crucial for immune defense mechanisms but also plays a role in the development of atherosclerosis. We have previously shown that inflammatory stimulation of endothelial cells on top of elevated lipopr…