Elisabeth Hirth
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View article: Engineered allogeneic T cells decoupling T-cell-receptor and CD3 signalling enhance the antitumour activity of bispecific antibodies
Engineered allogeneic T cells decoupling T-cell-receptor and CD3 signalling enhance the antitumour activity of bispecific antibodies Open
View article: “Periodontal ligament‐on‐chip” as a Novel Tool for Studies on the Physiology and Pathology of Periodontal Tissues
“Periodontal ligament‐on‐chip” as a Novel Tool for Studies on the Physiology and Pathology of Periodontal Tissues Open
Teeth exert fundamental physiological functions, such as mastication and speech, and are a key feature of oral health that affects life quality. Teeth are anchored to the alveolar bone via the periodontal ligament, which provides stability…
View article: Self-assembled and perfusable microvasculature-on-chip for modeling leukocyte trafficking
Self-assembled and perfusable microvasculature-on-chip for modeling leukocyte trafficking Open
We developed and characterized a biologically functional microcirculation system consisting of arterial and venous endothelial cells and pericytes. The model was employed to study leukocyte transendothelial migration in the healthy and inf…
View article: Multiplexed analysis of signalling proteins at the single-immune cell level
Multiplexed analysis of signalling proteins at the single-immune cell level Open
We analyse signalling factors secreted by single polarized macrophages. This is achieved by using a microfluidic device with microchamber arrays for co-capturing cells in hydrodynamic traps and functionalized beads in magnetic traps.