Elisabeth Moussaud-Lamodière
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View article: Image based subcellular mapping of the protein landscape of SARS-CoV-2 infected cells for target-centric drug repurposing
Image based subcellular mapping of the protein landscape of SARS-CoV-2 infected cells for target-centric drug repurposing Open
The COVID-19 pandemic has resulted in millions of deaths and affected socioeconomic structure worldwide and the search for new antivirals and treatments are still ongoing. In the search for new drug targets and to increase our understandin…
View article: P-402 Molecular and functional impact of X-ray on primary ovarian cells
P-402 Molecular and functional impact of X-ray on primary ovarian cells Open
Study question How does X-ray irradiation affect human primary ovarian cells (POCs) in vitro? Summary answer A single 10 Gy dose of irradiation in POCs significantly impacts cell-cell communication, cycle progression and cytoskeleton forma…
View article: Acute high-dose irradiation of human primary ovarian cells reveals a shift in transcriptomics profile and impairment in cell-cell adhesion
Acute high-dose irradiation of human primary ovarian cells reveals a shift in transcriptomics profile and impairment in cell-cell adhesion Open
STUDY QUESTION How do human cortical (cPOCs) and medullary (mPOCs) primary ovarian cells respond to acute X-ray exposure? SUMMARY ANSWER Acute high-dose X-ray exposure causes a shift in cPOCs and mPOCs transcriptomic profiles and impairs s…
View article: Single-Cell Transcriptomic Profiling Reveals Mehp-Induced Disruption of Core Cellular Processes Across All Cell Types in Human Ovarian Cortex
Single-Cell Transcriptomic Profiling Reveals Mehp-Induced Disruption of Core Cellular Processes Across All Cell Types in Human Ovarian Cortex Open
View article: In-depth analysis of transcriptomes in ovarian cortical follicles from children and adults reveals interfollicular heterogeneity
In-depth analysis of transcriptomes in ovarian cortical follicles from children and adults reveals interfollicular heterogeneity Open
View article: Exposure to the phthalate metabolite MEHP impacts survival and growth of human ovarian follicles in vitro
Exposure to the phthalate metabolite MEHP impacts survival and growth of human ovarian follicles in vitro Open
Phthalates are found in everyday items like plastics and personal care products. There is an increasing concern that continuous exposure can adversely affect female fertility. However, experimental data are lacking to establish causal link…
View article: Clinically compliant cryopreservation of differentiated retinal pigment epithelial cells
Clinically compliant cryopreservation of differentiated retinal pigment epithelial cells Open
The possibility of cryopreserving the hPSC-RPE product has been instrumental in our efforts in manufacturing and performing pre-clinical testing with the aim for clinical translation.
View article: SMAC mimetics overcome apoptotic resistance in ovarian cancer through MSLN-TNF alpha axis
SMAC mimetics overcome apoptotic resistance in ovarian cancer through MSLN-TNF alpha axis Open
Resistance to chemotherapy and PARPi inhibitors remains a critical challenge in the treatment of epithelial ovarian cancer, mainly due to disabled apoptotic responses in tumor cells. Given mesothelin’s pivotal role in ovarian cancer and it…
View article: Effects of chemical <i>in vitro</i> activation versus fragmentation on human ovarian tissue and follicle growth in culture
Effects of chemical <i>in vitro</i> activation versus fragmentation on human ovarian tissue and follicle growth in culture Open
STUDY QUESTION What is the effect of the chemical in vitro activation (cIVA) protocol compared with fragmentation only (Frag, also known as mechanical IVA) on gene expression, follicle activation and growth in human ovarian tissue in vitro…
View article: The drug efficacy testing in 3D cultures platform identifies effective drugs for ovarian cancer patients
The drug efficacy testing in 3D cultures platform identifies effective drugs for ovarian cancer patients Open
View article: The Drug Efficacy Testing in Ex Vivo 3D Cultures (DETECt) platform enables rapid identification of effective drugs and drug combinations for ovarian cancer patients
The Drug Efficacy Testing in Ex Vivo 3D Cultures (DETECt) platform enables rapid identification of effective drugs and drug combinations for ovarian cancer patients Open
Most patients with advanced ovarian cancer (OC) relapse and progress despite systemic therapy, pointing to the need for improved and tailored therapy options. Functional precision medicine can help to identify effective therapies for indiv…
View article: Subcellular mapping of the protein landscape of SARS-CoV-2 infected cells for target-centric drug repurposing
Subcellular mapping of the protein landscape of SARS-CoV-2 infected cells for target-centric drug repurposing Open
The COVID-19 pandemic has resulted in millions of deaths and affected socioeconomic structure worldwide and the search for new antivirals and treatments are still ongoing. In the search for new drug target and to increase our understanding…