Jin‐Moo Lee
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View article: Regional Brain Age is Decreased in Children with Sickle Cell Anemia
Regional Brain Age is Decreased in Children with Sickle Cell Anemia Open
DeepBrainNet, a machine learning tool, uses MRI to predict an individual's brain age, allowing calculation of the brain age gap (predicted - chronological age) for use as a biomarker of brain health. We tested the DeepBrainNet tool in sick…
View article: GWAS metanalysis of atrial fibrillation reveals significant sex-related heterogeneity effects of the PITX2 and CFL2 loci
GWAS metanalysis of atrial fibrillation reveals significant sex-related heterogeneity effects of the PITX2 and CFL2 loci Open
Background Atrial fibrillation (AF) exhibits notable sex differences in epidemiology and outcomes. This study investigates biological sex-specific differences in AF through sex-stratified genome-wide association studies (GWAS) and proteomi…
View article: Preoptic activation induces a torpor-like hypothermic and hypometabolic state that is cerebroprotective
Preoptic activation induces a torpor-like hypothermic and hypometabolic state that is cerebroprotective Open
Therapeutic hypothermia for stroke has been limited by shivering, increased metabolic demand, and poor patient tolerance. Engaging endogenous thermoregulatory circuits to lower body temperature may overcome these limitations and modulate m…
View article: Arousal as a universal embedding for spatiotemporal brain dynamics
Arousal as a universal embedding for spatiotemporal brain dynamics Open
View article: Stroke and motor outcomes are associated with regional and age‐specific changes in periodic and aperiodic cortical activity
Stroke and motor outcomes are associated with regional and age‐specific changes in periodic and aperiodic cortical activity Open
Historically, stroke and ageing have been associated with changes in narrow‐band periodic neuronal activity, but recent work has highlighted the importance of broad‐band aperiodic activity. Aperiodic activity is represented by the 1/ f slo…
View article: MRI signatures associated with active ischemia and disease severity in cerebral small vessel disease
MRI signatures associated with active ischemia and disease severity in cerebral small vessel disease Open
In conclusion, we found evidence that T1 and T2 FLAIR signal is heterogeneous in cerebral small vessel disease and is associated with disease severity. Within WMH, focal T1 hypointensity and variability, as well as T2 FLAIR hyperintensity …
View article: Current Status and Updates of Korean Medicine Clinical Practice Guidelines: A 2024 Review
Current Status and Updates of Korean Medicine Clinical Practice Guidelines: A 2024 Review Open
Background Korean Medicine (KM) has been a vital part of healthcare, providing holistic treatment approaches for diverse conditions. With the growing demand for integration with conventional medical frameworks, the development of evidence-…
View article: Harmonization of cerebral blood flow measurements by multi-delay 3D gradient and spin echo, and single-delay 2D echo planar imaging
Harmonization of cerebral blood flow measurements by multi-delay 3D gradient and spin echo, and single-delay 2D echo planar imaging Open
Purpose Cerebral blood flow (CBF) is commonly measured by pseudo-continuous arterial spin labeling (PCASL) in human research, but recent advancements in methodology have limited data reuse. The object of this work is to harmonize two disti…
View article: Cerebral arterial lumens are enlarged in children and young adults with sickle cell disease compared to peers
Cerebral arterial lumens are enlarged in children and young adults with sickle cell disease compared to peers Open
View article: 531 Novel inflammatory gene expression changes occur within the occluded vasculature of large vessel ischemic stroke
531 Novel inflammatory gene expression changes occur within the occluded vasculature of large vessel ischemic stroke Open
Objectives/Goals: We hypothesized that the bulk transcriptomic profiling of blood collected from within the ischemic vasculature during an acute ischemic stroke with large vessel occlusion (LVO) will contain unique biomarkers that are diff…
View article: γ-Secretase modulation inhibits amyloid plaque formation and growth and stimulates plaque regression in amyloid precursor protein/presenilin-1 mice
γ-Secretase modulation inhibits amyloid plaque formation and growth and stimulates plaque regression in amyloid precursor protein/presenilin-1 mice Open
γ-Secretase modulators (GSMs) represent an emerging oral therapy for preventing and targeting Aβ-amyloidosis in Alzheimer disease. Aβ is a family of peptides of varying lengths where both the total and relative amounts of the individual Aβ…
View article: Control of neurovascular coupling by ATP-sensitive potassium channels
Control of neurovascular coupling by ATP-sensitive potassium channels Open
Regional blood flow within the brain is tightly coupled to regional neuronal activity, a process known as neurovascular coupling (NVC). In this study, we demonstrate the striking role of SUR2- and Kir6.1-dependent ATP-sensitive potassium (…
View article: Regional Growth Rates of White Matter Hyperintensities are Associated with Beta-Amyloid Burden
Regional Growth Rates of White Matter Hyperintensities are Associated with Beta-Amyloid Burden Open
View article: Early changes in spatiotemporal dynamics of remapped circuits and global networks predict functional recovery after stroke in mice
Early changes in spatiotemporal dynamics of remapped circuits and global networks predict functional recovery after stroke in mice Open
These results suggest that diffuse patterns of remapping, and desynchronization and hyperconnectivity of cortical networks, evolving early after stroke may reflect maladaptive plasticity, predicting poor long-term functional recovery.
View article: Let’s Get Walking: Establishing Workplace Walking Groups in a regional Public Health Department
Let’s Get Walking: Establishing Workplace Walking Groups in a regional Public Health Department Open
Maintaining staff health and wellbeing (HWB) is an ongoing priority for the Department of Public Health HSE Dublin and Midlands (PHD). This is particularly important in the context of an ongoing programme of reform for Public Health in Ire…
View article: Spatiotemporal relationships between neuronal, metabolic, and hemodynamic signals in the awake and anesthetized mouse brain
Spatiotemporal relationships between neuronal, metabolic, and hemodynamic signals in the awake and anesthetized mouse brain Open
View article: Attention-based CNN-BiLSTM for sleep state classification of spatiotemporal wide-field calcium imaging data
Attention-based CNN-BiLSTM for sleep state classification of spatiotemporal wide-field calcium imaging data Open
The CNN-BiLSTM effectively classifies sleep states from spatiotemporal WFCI data and will enable broader application of WFCI in sleep research.
View article: Evaluating the interaction between hemorrhagic transformation and cerebral edema on functional outcome after ischemic stroke
Evaluating the interaction between hemorrhagic transformation and cerebral edema on functional outcome after ischemic stroke Open
View article: Intracranial aneurysms in sickle cell disease are associated with hemodynamic stress and anemia
Intracranial aneurysms in sickle cell disease are associated with hemodynamic stress and anemia Open
Although hemodynamic stress plays a key role in aneurysm formation outside of sickle cell disease (SCD), its role is understudied in patients with SCD. We hypothesized that tissue-based markers of hemodynamic stress are associated with ane…
View article: Evolution of white matter hyperintensity segmentation methods and implementation over the past two decades; an incomplete shift towards deep learning
Evolution of white matter hyperintensity segmentation methods and implementation over the past two decades; an incomplete shift towards deep learning Open
This systematic review examines the prevalence, underlying mechanisms, cohort characteristics, evaluation criteria, and cohort types in white matter hyperintensity (WMH) pipeline and implementation literature spanning the last two decades.…
View article: Genetic Variation and Stroke Recovery: The STRONG Study
Genetic Variation and Stroke Recovery: The STRONG Study Open
BACKGROUND: Genetic association studies can reveal biology and treatment targets but have received limited attention for stroke recovery. STRONG (Stroke, Stress, Rehabilitation, and Genetics) was a prospective, longitudinal (1-year), genet…
View article: Identifying Functional Brain Networks of Spatiotemporal Wide-Field Calcium Imaging Data via a Long Short-Term Memory Autoencoder
Identifying Functional Brain Networks of Spatiotemporal Wide-Field Calcium Imaging Data via a Long Short-Term Memory Autoencoder Open
Wide-field calcium imaging (WFCI) that records neural calcium dynamics allows for identification of functional brain networks (FBNs) in mice that express genetically encoded calcium indicators. Estimating FBNs from WFCI data is commonly ac…
View article: Effects of Amyloid Beta (Aβ) Oligomers on Blood–Brain Barrier Using a 3D Microfluidic Vasculature-on-a-Chip Model
Effects of Amyloid Beta (Aβ) Oligomers on Blood–Brain Barrier Using a 3D Microfluidic Vasculature-on-a-Chip Model Open
The disruption of the blood–brain barrier (BBB) in Alzheimer’s Disease (AD) is largely influenced by amyloid beta (Aβ). In this study, we developed a high-throughput microfluidic BBB model devoid of a physical membrane, featuring endotheli…
View article: Comparison of cerebral oxygen extraction fraction using ASE and TRUST methods in patients with sickle cell disease and healthy controls
Comparison of cerebral oxygen extraction fraction using ASE and TRUST methods in patients with sickle cell disease and healthy controls Open
Abnormal oxygen extraction fraction (OEF), a putative biomarker of cerebral metabolic stress, may indicate compromised oxygen delivery and ischemic vulnerability in patients with sickle cell disease (SCD). Elevated OEF was observed at the …
View article: GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes Open
Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studi…
View article: Chimeric antigen receptor macrophages target and resorb amyloid plaques
Chimeric antigen receptor macrophages target and resorb amyloid plaques Open
Substantial evidence suggests a role for immunotherapy in treating Alzheimer's disease (AD). While the precise pathophysiology of AD is incompletely understood, clinical trials of antibodies targeting aggregated forms of β amyloid (Aβ) hav…
View article: Impact of Sleep Disorders and Disturbed Sleep on Brain Health: A Scientific Statement From the American Heart Association
Impact of Sleep Disorders and Disturbed Sleep on Brain Health: A Scientific Statement From the American Heart Association Open
Accumulating evidence supports a link between sleep disorders, disturbed sleep, and adverse brain health, ranging from stroke to subclinical cerebrovascular disease to cognitive outcomes, including the development of Alzheimer disease and …
View article: Attention-Based CNN-BiLSTM for Sleep State Classification of Spatiotemporal Wide-Field Calcium Imaging Data
Attention-Based CNN-BiLSTM for Sleep State Classification of Spatiotemporal Wide-Field Calcium Imaging Data Open
Background: Wide-field calcium imaging (WFCI) with genetically encoded calcium indicators allows for spatiotemporal recordings of neuronal activity in mice. When applied to the study of sleep, WFCI data are manually scored into the sleep s…
View article: Accuracy of TrUE-Net in comparison to established white matter hyperintensity segmentation methods: An independent validation study
Accuracy of TrUE-Net in comparison to established white matter hyperintensity segmentation methods: An independent validation study Open
View article: Phospholipase D3 drives microglial response to amyloid pathology in Alzheimer’s disease
Phospholipase D3 drives microglial response to amyloid pathology in Alzheimer’s disease Open
Background Amyloid‐beta (Aβ) plaque formation is a well‐established hallmark for Alzheimer’s disease (AD). However, the processes behind plaque formation are not understood. Previous work from our group identified rare coding variants for …