Élise Dumas
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View article: Avoiding biases when estimating effects of COVID-19 vaccination during immune checkpoint inhibitor therapy
Avoiding biases when estimating effects of COVID-19 vaccination during immune checkpoint inhibitor therapy Open
SARS-CoV-2 mRNA vaccination (COVID-19 vaccination) within 100 days of immune checkpoint inhibitor (ICI) treatment was reported to improve survival and prevent disease progression in patients with non-small cell lung cancer (NSCLC) and meta…
View article: Multimodal BEHRT: transformers for multimodal electronic health records to predict breast cancer prognosis
Multimodal BEHRT: transformers for multimodal electronic health records to predict breast cancer prognosis Open
Background Electronic Health Records (EHRs) contain a wealth of information about patients that could be useful toward improving treatment outcomes for breast cancer patients, but remain mostly unexploited. Recent methodological developmen…
View article: Impact of Antihypertensive Treatment on Outcomes of Adjuvant Bevacizumab for Ovarian Cancer (<scp>IATRO</scp>), Results from a Nationwide Emulated Clinical Trial
Impact of Antihypertensive Treatment on Outcomes of Adjuvant Bevacizumab for Ovarian Cancer (<span>IATRO</span>), Results from a Nationwide Emulated Clinical Trial Open
Antiangiogenic therapy with bevacizumab improves outcomes in ovarian cancer but induces hypertension, leading to major adverse cardiovascular events (MACE). While calcium channel blockers (CCBs) and angiotensin‐converting enzyme inhibitors…
View article: Time-to-pregnancy in patients with previous breast cancer and unexposed women: a prospective exposed-unexposed cohort study
Time-to-pregnancy in patients with previous breast cancer and unexposed women: a prospective exposed-unexposed cohort study Open
View article: Vinorelbine With or Without Thiotepa for <scp>HER2</scp>‐Negative Metastatic Breast Cancer: A Propensity Score Analysis
Vinorelbine With or Without Thiotepa for <span>HER2</span>‐Negative Metastatic Breast Cancer: A Propensity Score Analysis Open
Background Vinorelbine is commonly used to treat metastatic breast cancer (mBC), while thiotepa is known for its ability to cross the blood–brain barrier. Methods Our retrospective study aimed to compare the efficacy and safety of vinorelb…
View article: Comedications Associated with Immune‐Related Adverse Events from Immune‐Checkpoint Inhibitors
Comedications Associated with Immune‐Related Adverse Events from Immune‐Checkpoint Inhibitors Open
Immune‐checkpoint inhibitors (ICI) have revolutionized cancer treatment but are responsible for various immune‐related adverse events (irAE). The impact of non‐anticancer medications (comedications) on irAE occurrence remains largely unexp…
View article: How hazard ratios can mislead and why it matters in practice
How hazard ratios can mislead and why it matters in practice Open
Hazard ratios are routinely reported as effect measures in clinical trials and observational studies. However, many methodological works have raised concerns about the interpretation of hazard ratios as causal effects. These concerns are o…
View article: <scp>BCR</scp>::<scp>ABL1</scp> Tyrosine Kinase Inhibitors During Pregnancy, a Disproportionality Analysis of Vigibase
<span>BCR</span>::<span>ABL1</span> Tyrosine Kinase Inhibitors During Pregnancy, a Disproportionality Analysis of Vigibase Open
Tyrosine kinase inhibitors (TKIs) targeting BCR::ABL1 have greatly improved the survival of patients with chronic myeloid leukemia (CML), and their teratogenicity appears as an important factor for individuals of childbearing potential. Th…
View article: Causal analyses of the impact of comorbid conditions and concomitant medications on response to neoadjuvant chemotherapy in breast cancer: analysis of a multicenter prospective cohort study (CANTO)
Causal analyses of the impact of comorbid conditions and concomitant medications on response to neoadjuvant chemotherapy in breast cancer: analysis of a multicenter prospective cohort study (CANTO) Open
The use of several classes of concomitant medication during NAC can be associated with changes in pCR rates. Further research is needed on the interactions between NAC and chronic non-anticancer drug use.
View article: From Prediction to Prescription: Machine Learning and Causal Inference for the Heterogeneous Treatment Effect
From Prediction to Prescription: Machine Learning and Causal Inference for the Heterogeneous Treatment Effect Open
The increasing accumulation of medical data brings the hope of data-driven medical decision-making, but data's increasing complexity—as text or images in electronic health records—calls for complex models, such as machine learning. Here, w…
View article: From prediction to prescription: Machine learning and Causal Inference
From prediction to prescription: Machine learning and Causal Inference Open
International audience
View article: A reproducible framework for monitoring the impact of randomized clinical trials on clinical practice using large-scale real-world data: application to gynaecological surgical trials using the French national healthcare database
A reproducible framework for monitoring the impact of randomized clinical trials on clinical practice using large-scale real-world data: application to gynaecological surgical trials using the French national healthcare database Open
None.
View article: Causality: fundamental principles and tools
Causality: fundamental principles and tools Open
View article: Association between Daily Timing of Everolimus Combined with Adjuvant Endocrine Therapy with Survival Outcomes in Patients with High-Risk Hormone Positive and Her2 Negative Early Breast Cancer: Results of a Sub-Study of the UCBG- UNIRAD Trial
Association between Daily Timing of Everolimus Combined with Adjuvant Endocrine Therapy with Survival Outcomes in Patients with High-Risk Hormone Positive and Her2 Negative Early Breast Cancer: Results of a Sub-Study of the UCBG- UNIRAD Trial Open
View article: Association between Daily Timing of Everolimus Combined with Adjuvant Endocrine Therapy with Survival Outcomes in Patients with High-Risk Hormone Positive and Her2 Negative Early Breast Cancer: Results of a Sub-Study of the Ucbg- Unirad Trial
Association between Daily Timing of Everolimus Combined with Adjuvant Endocrine Therapy with Survival Outcomes in Patients with High-Risk Hormone Positive and Her2 Negative Early Breast Cancer: Results of a Sub-Study of the Ucbg- Unirad Trial Open
View article: A Prospective Exposed-Unexposed Cohort Study Comparing Time-to-Pregnancy in Patients with Previous Breast Cancer and Controls from a Collaborative Research Network: Results after Three Years of Follow-Up
A Prospective Exposed-Unexposed Cohort Study Comparing Time-to-Pregnancy in Patients with Previous Breast Cancer and Controls from a Collaborative Research Network: Results after Three Years of Follow-Up Open
View article: Radiotherapy for oligoprogressive disease in non-small cell lung cancer treated with pembrolizumab in first-line setting: a retrospective study
Radiotherapy for oligoprogressive disease in non-small cell lung cancer treated with pembrolizumab in first-line setting: a retrospective study Open
In this study, RT alongside the maintenance of pembrolizumab for patients experiencing OP during first-line pembrolizumab-based therapy for mNSCLC demonstrated an acceptable safety profile and favorable outcomes. Data from phase 3 randomiz…
View article: Vaginal estrogen therapy initiation after breast cancer and oncological outcomes: a nationwide population-based target trial emulation.
Vaginal estrogen therapy initiation after breast cancer and oncological outcomes: a nationwide population-based target trial emulation. Open
Background: Genitourinary syndrome of menopause (GSM) frequently occurs after breast cancer (BC), leading to symptoms that can severely affect quality of life. Vaginal estrogen therapies (VETs), including compounds like promestriene and es…
View article: Survival outcomes of primary vs interval cytoreductive surgery for International Federation of Gynecology and Obstetrics stage IV ovarian cancer: a nationwide population-based target trial emulation
Survival outcomes of primary vs interval cytoreductive surgery for International Federation of Gynecology and Obstetrics stage IV ovarian cancer: a nationwide population-based target trial emulation Open
This study advocates for the benefits of primary cytoreductive surgery over interval cytoreductive surgery for patients with stage IV ovarian cancer and suggests that extraperitoneal metastases like supradiaphragmatic or extra-abdominal ly…
View article: Sex-related differences in oncological surgery and postoperative outcomes: comprehensive, nationwide study in France
Sex-related differences in oncological surgery and postoperative outcomes: comprehensive, nationwide study in France Open
Background The main objective of this study was to undertake an exhaustive investigation of sex-related differences in cancer surgery. Methods This observational study used data from the French national health insurance system database cov…
View article: Association between endocrine adjuvant therapy intake timing and disease-free survival in patients with high-risk early breast cancer: results of a sub-study of the UCBG- UNIRAD trial
Association between endocrine adjuvant therapy intake timing and disease-free survival in patients with high-risk early breast cancer: results of a sub-study of the UCBG- UNIRAD trial Open
View article: Immune Checkpoint Inhibitor Use During Pregnancy and Outcomes in Pregnant Individuals and Newborns
Immune Checkpoint Inhibitor Use During Pregnancy and Outcomes in Pregnant Individuals and Newborns Open
Importance With the widespread use of immune checkpoint inhibitors (ICIs), concerns about their pregnancy outcomes through maternal exposure have emerged, and clinical comparative data are lacking. Objective To assess the risk of pregnancy…
View article: Concomitant medication, comorbidity and survival in patients with breast cancer
Concomitant medication, comorbidity and survival in patients with breast cancer Open
View article: Clinical spectrum and evolution of immune-checkpoint inhibitors toxicities over a decade—a worldwide perspective
Clinical spectrum and evolution of immune-checkpoint inhibitors toxicities over a decade—a worldwide perspective Open
Paul Gougis was supported by the academic program: "Contrats ED: Programme blanc Institut Curie PSL" for the conduct of his PhD. Baptiste Abbar was supported by "the Fondation ARC Pour le Rechercher Sur le Cancer". The RT2L research group …
View article: Early morning immune checkpoint blockade and overall survival of patients with metastatic cancer: An In-depth chronotherapeutic study
Early morning immune checkpoint blockade and overall survival of patients with metastatic cancer: An In-depth chronotherapeutic study Open
View article: Ablative Radiotherapy for Oligoprogressive Disease in Non-Small Cell Lung Cancer Treated with Pembrolizumab in First-Line Setting: A Retrospective Study
Ablative Radiotherapy for Oligoprogressive Disease in Non-Small Cell Lung Cancer Treated with Pembrolizumab in First-Line Setting: A Retrospective Study Open
View article: Effects of gender and socio-environmental factors on health-care access in oncology: a comprehensive, nationwide study in France
Effects of gender and socio-environmental factors on health-care access in oncology: a comprehensive, nationwide study in France Open
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View article: Treatments During Pregnancy Targeting ERBB2 and Outcomes of Pregnant Individuals and Newborns
Treatments During Pregnancy Targeting ERBB2 and Outcomes of Pregnant Individuals and Newborns Open
Importance Targeted therapies directed against ERBB2 are the cornerstone of medical treatment for ERBB2-positive breast cancers but are contraindicated during pregnancy. Objectives To describe the association of exposure to anti-ERBB2 agen…
View article: Early Morning Checkpoint Inhibitor Infusion and Overall Survival of Patients with Metastatic Cancer: an In-depth Chronotherapeutic Study
Early Morning Checkpoint Inhibitor Infusion and Overall Survival of Patients with Metastatic Cancer: an In-depth Chronotherapeutic Study Open
Introduction Recent retrospective studies suggest potential large patient’s benefit through proper timing of immune checkpoint inhibitors (ICI). The association between ICI treatment timing and patient survival, neoplastic response and tox…
View article: Evolution of synchronous female bilateral breast cancers and response to treatment
Evolution of synchronous female bilateral breast cancers and response to treatment Open
Synchronous bilateral breast cancer (sBBC) occurs after both breasts have been affected by the same germline genetics and environmental exposures. Little evidence exists regarding immune infiltration and response to treatment in sBBCs. Her…