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View article: Somatic mosaicism in schizophrenia brains reveals prenatal mutational processes
Somatic mosaicism in schizophrenia brains reveals prenatal mutational processes Open
Germline mutations modulate the risk of developing schizophrenia (SCZ). Much less is known about the role of mosaic somatic mutations in the context of SCZ. Deep (239×) whole-genome sequencing (WGS) of brain neurons from 61 SCZ cases and 2…
View article: Demonstration of <i>in vivo</i> engineered tandem duplications of varying sizes using CRISPR and recombinases in <i>Drosophila melanogaster</i>
Demonstration of <i>in vivo</i> engineered tandem duplications of varying sizes using CRISPR and recombinases in <i>Drosophila melanogaster</i> Open
Tandem gene duplicates are important parts of eukaryotic genome structure, yet the phenotypic effects of new tandem duplications are not well-understood, in part owing to a lack of techniques to build and modify them. We introduce a method…
View article: Demonstration of<i>in vivo</i>engineered tandem duplications of varying sizes using CRISPR and recombinases in<i>Drosophila melanogaster</i>
Demonstration of<i>in vivo</i>engineered tandem duplications of varying sizes using CRISPR and recombinases in<i>Drosophila melanogaster</i> Open
Tandem gene duplicates are important parts of eukaryotic genome structure, yet the phenotypic effects of new tandem duplications are not well-understood, in part owing to a lack of techniques to build and modify them. We introduce a method…