Elissa D. Pastuzyn
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View article: Functional immune mapping with deep-learning enabled phenomics applied to immunomodulatory and COVID-19 drug discovery
Functional immune mapping with deep-learning enabled phenomics applied to immunomodulatory and COVID-19 drug discovery Open
Development of accurate disease models and discovery of immune-modulating drugs is challenged by the immune system’s highly interconnected and context-dependent nature. Here we apply deep-learning-driven analysis of cellular morphology to …
View article: Publisher Correction: Three-dimensional genome restructuring across timescales of activity-induced neuronal gene expression
Publisher Correction: Three-dimensional genome restructuring across timescales of activity-induced neuronal gene expression Open
View article: Three-dimensional genome restructuring across timescales of activity-induced neuronal gene expression
Three-dimensional genome restructuring across timescales of activity-induced neuronal gene expression Open
View article: The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling
The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling Open
Symbiotic microbes impact the function and development of the central nervous system (CNS); however, little is known about the contribution of the microbiota during viral-induced neurologic damage. We identify that commensals aid in host d…
View article: Author response: The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling
Author response: The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Symbiotic microbes impact the…
View article: Striatal learning and memory after methamphetamine-induced neurotoxicity and subsequent restoration of striatal function
Striatal learning and memory after methamphetamine-induced neurotoxicity and subsequent restoration of striatal function Open
View article: The Temporal Dynamics of Arc Expression Regulate Cognitive Flexibility
The Temporal Dynamics of Arc Expression Regulate Cognitive Flexibility Open
View article: The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer
The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer Open
View article: The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer
The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer Open
View article: Arc restores juvenile plasticity in adult mouse visual cortex
Arc restores juvenile plasticity in adult mouse visual cortex Open
Significance Neuronal plasticity peaks early in life during critical periods and normally declines with age, but the molecular changes that underlie this decline are not fully understood. Using the mouse visual cortex as a model, we found …
View article: Activity-Dependent Arc Expression and Homeostatic Synaptic Plasticity Are Altered in Neurons from a Mouse Model of Angelman Syndrome
Activity-Dependent Arc Expression and Homeostatic Synaptic Plasticity Are Altered in Neurons from a Mouse Model of Angelman Syndrome Open
Angelman syndrome (AS) is a neurodevelopmental disorder that results from deletions or mutations in chromosome 15, which usually includes the UBE3A gene. Ube3A protein is an E3 ubiquitin ligase that ubiquitinates proteins and target…
View article: Arc restores juvenile plasticity in adult mouse visual cortex
Arc restores juvenile plasticity in adult mouse visual cortex Open
The molecular basis for the decline in experience-dependent neural plasticity over age remains poorly understood. In visual cortex, the robust plasticity induced in juvenile mice by brief monocular deprivation (MD) during the critical peri…
View article: Deep-brain imaging via epi-fluorescence Computational Cannula Microscopy
Deep-brain imaging via epi-fluorescence Computational Cannula Microscopy Open
Here we demonstrate widefield (field diameter = 200 μm) fluorescence microscopy and video imaging inside the rodent brain at a depth of 2 mm using a simple surgical glass needle (cannula) of diameter 0.22 mm as the primary optical element.…