Elissa Yozawitz
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View article: Neonatal seizures: Advances in diagnosis and management
Neonatal seizures: Advances in diagnosis and management Open
The International League Against Epilepsy (ILAE) created the ILAE Neonatal Task Force that classified neonatal seizures, defined neonatal epilepsy syndromes, and specified treatment guidelines. These frameworks, in addition to improved acc…
View article: Comparative effectiveness of second‐line treatments for epileptic spasms
Comparative effectiveness of second‐line treatments for epileptic spasms Open
Objective This study was undertaken to evaluate the response to second treatments for infantile epileptic spasms syndrome (IESS). Methods Infants aged 2–24 months with IESS were prospectively enrolled in the National Infantile Spasms Cohor…
View article: A Multicenter Retrospective Observational Cohort Study of Seizure Freedom before Lennox-Gastaut Syndrome (the “Gap”). Opportunities for Prevention
A Multicenter Retrospective Observational Cohort Study of Seizure Freedom before Lennox-Gastaut Syndrome (the “Gap”). Opportunities for Prevention Open
Objective Lennox-Gastaut Syndrome (LGS) is a severe, often treatment-resistant epilepsy syndrome typically diagnosed in early childhood. Many have seizures before diagnosis. Some have periods of seizure freedom before treatment resistance,…
View article: Defining neonatal status epilepticus: A scoping review from the <scp>ILAE</scp> neonatal task force
Defining neonatal status epilepticus: A scoping review from the <span>ILAE</span> neonatal task force Open
Objective To review the available literature concerning the definition of neonatal status epilepticus (SE) and/or seizure burden. Methods The International League Against Epilepsy Neonatal Task Force performed a scoping review of the defin…
View article: <scp>Population‐based</scp> study of rare epilepsy incidence in a <scp>US</scp> urban population
<span>Population‐based</span> study of rare epilepsy incidence in a <span>US</span> urban population Open
Objective This study was undertaken to estimate incidence of rare epilepsies and compare with literature. Methods We used electronic health record text search to identify children with 28 rare epilepsies in New York City (2010–2014). We es…
View article: Neonatal Seizures: New Evidence, Classification, and Guidelines
Neonatal Seizures: New Evidence, Classification, and Guidelines Open
Neonates are susceptible to seizures due to their unique physiology and combination of risks associated with gestation, delivery, and the immediate postnatal period. Advances in neonatal care have improved outcomes for some of our most fra…
View article: Treatment of seizures in the neonate: Guidelines and consensus‐based recommendations—Special report from the <scp>ILAE</scp> Task Force on Neonatal Seizures
Treatment of seizures in the neonate: Guidelines and consensus‐based recommendations—Special report from the <span>ILAE</span> Task Force on Neonatal Seizures Open
Seizures are common in neonates, but there is substantial management variability. The Neonatal Task Force of the International League Against Epilepsy (ILAE) developed evidence‐based recommendations about antiseizure medication (ASM) manag…
View article: Creating rare epilepsy cohorts using keyword search in electronic health records
Creating rare epilepsy cohorts using keyword search in electronic health records Open
Objective Administrative codes to identify people with rare epilepsies in electronic health records are limited. The current study evaluated the use of keyword search as an alternative method for rare epilepsy cohort creation using electro…
View article: Epileptiform discharges, electrographic seizures, and electroclinical seizures during paediatric sevoflurane anaesthesia. Response to Br J Anaesth 2023; 130: e423–e424
Epileptiform discharges, electrographic seizures, and electroclinical seizures during paediatric sevoflurane anaesthesia. Response to Br J Anaesth 2023; 130: e423–e424 Open
View article: Application of the International League Against Epilepsy Neonatal Seizure Framework to an international panel of medical personnel
Application of the International League Against Epilepsy Neonatal Seizure Framework to an international panel of medical personnel Open
Objective The International League Against Epilepsy (ILAE) Neonatal Seizure Framework was tested by medical personnel. Methods Attendees at the 2016 ILAE European Congress on Epileptology in Prague, the International Video‐EEG Course in Pe…
View article: The TeleKidSeq pilot study: incorporating telehealth into clinical care of children from diverse backgrounds undergoing whole genome sequencing
The TeleKidSeq pilot study: incorporating telehealth into clinical care of children from diverse backgrounds undergoing whole genome sequencing Open
View article: Epileptiform discharges, electrographic seizures, and electroclinical seizures during paediatric sevoflurane anaesthesia: a systematic review and proposal for standard definitions
Epileptiform discharges, electrographic seizures, and electroclinical seizures during paediatric sevoflurane anaesthesia: a systematic review and proposal for standard definitions Open
View article: The influence of genetics on epilepsy syndromes in infancy and childhood
The influence of genetics on epilepsy syndromes in infancy and childhood Open
Genetics is rapidly evolving and is actively playing a role in how we diagnose and manage epilepsy. The definition of an epilepsy syndrome has changed throughout the years. The International League Against Epilepsy (ILAE) has developed a c…
View article: Medical treatment in infants and young children with epilepsy: Off‐label use of antiseizure medications. Survey Report of ILAE Task Force Medical Therapies in Children
Medical treatment in infants and young children with epilepsy: Off‐label use of antiseizure medications. Survey Report of ILAE Task Force Medical Therapies in Children Open
Objective Antiseizure medications (ASMs) remain the mainstay of epilepsy treatment. These ASMs have mainly been tested in trials in adults with epilepsy, which subsequently led to market authorization (MA). For treatment of – especially yo…
View article: Association of Time to Clinical Remission With Sustained Resolution in Children With New-Onset Infantile Spasms
Association of Time to Clinical Remission With Sustained Resolution in Children With New-Onset Infantile Spasms Open
Remission after first infantile spasms treatment can be identified by treatment day 7 in most children. Given the importance of early and effective treatment, these data suggest that children who do not respond to standard infantile spasms…
View article: ILAE classification and definition of epilepsy syndromes with onset in neonates and infants: Position statement by the ILAE Task Force on Nosology and Definitions
ILAE classification and definition of epilepsy syndromes with onset in neonates and infants: Position statement by the ILAE Task Force on Nosology and Definitions Open
The International League Against Epilepsy (ILAE) Task Force on Nosology and Definitions proposes a classification and definition of epilepsy syndromes in the neonate and infant with seizure onset up to 2 years of age. The incidence of epil…
View article: International League Against Epilepsy classification and definition of epilepsy syndromes with onset in childhood: Position paper by the ILAE Task Force on Nosology and Definitions
International League Against Epilepsy classification and definition of epilepsy syndromes with onset in childhood: Position paper by the ILAE Task Force on Nosology and Definitions Open
The 2017 International League Against Epilepsy classification has defined a three‐tier system with epilepsy syndrome identification at the third level. Although a syndrome cannot be determined in all children with epilepsy, identification …
View article: Inequities in Therapy for Infantile Spasms: A Call to Action
Inequities in Therapy for Infantile Spasms: A Call to Action Open
Objective The aim of this study was to determine whether selection of treatment for children with infantile spasms (IS) varies by race/ethnicity. Methods The prospective US National Infantile Spasms Consortium database includes children wi…
View article: Why monitor the neonatal brain—that is the important question
Why monitor the neonatal brain—that is the important question Open
View article: 244 A Systematic Review of Epileptiform Changes During Sevoflurane Anesthesia In Infants and Children
244 A Systematic Review of Epileptiform Changes During Sevoflurane Anesthesia In Infants and Children Open
OBJECTIVES/GOALS: Early clinical case reports have described incidental epileptiform changes during electrophysiological monitoring. The objective of this study was to perform a systematic review of all existing investigations of epileptif…
View article: eP236: TeleKidSeq: Incorporating telehealth into clinical care of children from diverse backgrounds undergoing clinical genome sequencing
eP236: TeleKidSeq: Incorporating telehealth into clinical care of children from diverse backgrounds undergoing clinical genome sequencing Open
View article: Decreased Electroencephalographic Alpha Power During Anesthesia Induction Is Associated With EEG Discontinuity in Human Infants
Decreased Electroencephalographic Alpha Power During Anesthesia Induction Is Associated With EEG Discontinuity in Human Infants Open
BACKGROUND: Electroencephalogram (EEG) discontinuity can occur at high concentrations of anesthetic drugs, reflecting suppression of electrocortical activity. This EEG pattern has been reported in children and reflects a deep state of anes…
View article: Electroencephalographic assessment of infant spinal anesthesia: A pilot prospective observational study
Electroencephalographic assessment of infant spinal anesthesia: A pilot prospective observational study Open
Introduction Spinal anesthesia is utilized as an alternative to general anesthesia in infants for some surgeries. After spinal anesthesia, infants often become less conscious without administration of sedative medications. The aim of this …
View article: Comparative Effectiveness of Initial Treatment for Infantile Spasms in a Contemporary US Cohort
Comparative Effectiveness of Initial Treatment for Infantile Spasms in a Contemporary US Cohort Open
This study provides Class III evidence that for children with new-onset infantile spasms, ACTH or oral steroids were superior to nonstandard therapies.
View article: Correction to: The NYCKidSeq project: study protocol for a randomized controlled trial incorporating genomics into the clinical care of diverse New York City children
Correction to: The NYCKidSeq project: study protocol for a randomized controlled trial incorporating genomics into the clinical care of diverse New York City children Open
View article: The ILAE classification of seizures and the epilepsies: Modification for seizures in the neonate. Position paper by the ILAE Task Force on Neonatal Seizures
The ILAE classification of seizures and the epilepsies: Modification for seizures in the neonate. Position paper by the ILAE Task Force on Neonatal Seizures Open
Seizures are the most common neurological emergency in the neonatal period and in contrast to those in infancy and childhood, are often provoked seizures with an acute cause and may be electrographic‐only. Hence, neonatal seizures may not …
View article: The NYCKidSeq project: study protocol for a randomized controlled trial incorporating genomics into the clinical care of diverse New York City children
The NYCKidSeq project: study protocol for a randomized controlled trial incorporating genomics into the clinical care of diverse New York City children Open
View article: Erratum
Erratum Open
View article: Design and implementation of electronic health record common data elements for pediatric epilepsy: Foundations for a learning health care system
Design and implementation of electronic health record common data elements for pediatric epilepsy: Foundations for a learning health care system Open
Objective Common data elements (CDEs) are standardized questions and answer choices that allow aggregation, analysis, and comparison of observations from multiple sources. Clinical CDEs are foundational for learning health care systems, a …
View article: Clinical and electrographic features of persistent seizures and status epilepticus associated with anti‐NMDA receptor encephalitis (anti‐NMDARE)
Clinical and electrographic features of persistent seizures and status epilepticus associated with anti‐NMDA receptor encephalitis (anti‐NMDARE) Open
Aims . Based on a multicenter cohort of people with anti‐NMDA receptor encephalitis (anti‐NMDARE), we describe seizure phenotypes, electroencephalographic (EEG) findings, and anti‐seizure treatment strategies. We also investigated whether …