Elissah Granger
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View article: Fancl-mutant mice reveal central role of monoubiquitination in Fanconi anemia and a model for therapeutic gene editing
Fancl-mutant mice reveal central role of monoubiquitination in Fanconi anemia and a model for therapeutic gene editing Open
Fanconi anemia (FA) is a rare genetic disorder causing progressive loss of hematopoietic stem cells (HSCs) and bone marrow failure. Most cases result from deficient monoubiquitination of FANCD2 by the FA core complex. However, as additiona…
View article: Multi-lineage natural gene therapy mediated by embryonic triploid mosaicism in the context of Fanconi anaemia
Multi-lineage natural gene therapy mediated by embryonic triploid mosaicism in the context of Fanconi anaemia Open
Summary Fanconi anemia is a rare inherited bone marrow failure syndrome caused by inactivation of genes in the Fanconi anemia/BRCA DNA repair pathway. We report a patient with X-linked Fanconi anemia, and atypical physical features whose g…
View article: Clinical and genetic spectrum of Fanconi anemia in Australia and New Zealand
Clinical and genetic spectrum of Fanconi anemia in Australia and New Zealand Open
View article: Clinical and Genetic Spectrum of Fanconi Anaemia in Australia and New Zealand
Clinical and Genetic Spectrum of Fanconi Anaemia in Australia and New Zealand Open
Fanconi anaemia (FA) is a rare genetic condition which predisposes to progressive bone marrow failure, a specific spectrum of malignancies including head and neck squamous cell carcinoma (HNSCC), and an array of other clinical manifestatio…
View article: Fancm has dual roles in the limiting of meiotic crossovers and germ cell maintenance in mammals
Fancm has dual roles in the limiting of meiotic crossovers and germ cell maintenance in mammals Open
Meiotic crossovers are required for accurate chromosome segregation and producing new allelic combinations. Meiotic crossover numbers are tightly regulated within a narrow range, despite an excess of initiating DNA double-strand breaks. He…
View article: <i>Fancm</i> regulates meiotic double-strand break repair pathway choice in mammals
<i>Fancm</i> regulates meiotic double-strand break repair pathway choice in mammals Open
Meiotic crossovers are required for accurate chromosome segregation and to produce new allelic combinations. Meiotic crossover numbers are tightly regulated within a narrow range, despite an excess of initiating DNA double-strand breaks. H…