Eleanor Harris
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View article: Torso synthetic CT generation by integrating deep learning and segmentation for FDG-PET/MR attenuation correction
Torso synthetic CT generation by integrating deep learning and segmentation for FDG-PET/MR attenuation correction Open
Introduction. Positron Emission Tomography/Magnetic Resonance ( PET/MR ) offers benefits over PET/CT including simultaneous PET and MR acquisition, intrinsic spatial registration accuracy, MR-based functional information, and superior soft…
View article: Stereotactic radiosurgery for brain metastasis from gynecological cancers: A systematic review
Stereotactic radiosurgery for brain metastasis from gynecological cancers: A systematic review Open
Background Though rare in gynecologic cancers, brain metastases have become more frequently diagnosed, likely due to improved treatments and clinical awareness. Stereotactic radiosurgery (SRS) is a precise treatment option showing promise …
View article: Prehabilitation for Patients with Cancer Undergoing Radiation Therapy: a Scoping Review
Prehabilitation for Patients with Cancer Undergoing Radiation Therapy: a Scoping Review Open
Prehabilitation is adaptive and tailored to specific patient and site needs; thus it is applied across a wide range of cancer sites. More interventions by which radiation therapy is the definitive treatment modality and larger sample sizes…
View article: Omission of Radiotherapy After Breast-Conserving Surgery for Women With Breast Cancer With Low Clinical and Genomic Risk: 5-Year Outcomes of IDEA
Omission of Radiotherapy After Breast-Conserving Surgery for Women With Breast Cancer With Low Clinical and Genomic Risk: 5-Year Outcomes of IDEA Open
PURPOSE Multiple studies have shown a low risk of ipsilateral breast events (IBEs) or other recurrences for selected patients age 65-70 years or older with stage I breast cancers treated with breast-conserving surgery (BCS) and endocrine t…
View article: RADT-14. ROLE OF CHEMOTHERAPY AFTER RADIATION THERAPY FOR GYNECOLOGIC METASTASES TO THE BRAIN
RADT-14. ROLE OF CHEMOTHERAPY AFTER RADIATION THERAPY FOR GYNECOLOGIC METASTASES TO THE BRAIN Open
BACKGROUND Brain metastasis from gynecologic malignancy is rare, and the optimal treatment is undetermined. METHODS Retrospective data was collected at a single institution from 2001-2021 on 66 patients with brain metastasis from gynecolog…
View article: P70 Evaluation of patient experience of a self-referral chest xray service piloted in areas of greater manchester
P70 Evaluation of patient experience of a self-referral chest xray service piloted in areas of greater manchester Open
Introduction Increasing the uptake chest X-rays (CXRs) in patients with the common symptoms of lung cancer might lead to a stage-shift towards early diagnosis of lung cancer. However, symptomatic patients experience numerous barriers to ac…
View article: What are the barriers and facilitators of clozapine use in early psychosis? A survey of UK early intervention clinicians
What are the barriers and facilitators of clozapine use in early psychosis? A survey of UK early intervention clinicians Open
Clozapine is the most effective medication for treatment-resistant psychosis, but evidence points to substantial underuse, especially within early intervention psychosis (EIP) services. We explored clinicians’ views on perceived barriers a…
View article: Data from Validation of a Radiosensitivity Molecular Signature in Breast Cancer
Data from Validation of a Radiosensitivity Molecular Signature in Breast Cancer Open
Purpose: Previously, we developed a radiosensitivity molecular signature [radiosensitivity index (RSI)] that was clinically validated in 3 independent datasets (rectal, esophageal, and head and neck) in 118 patients. Here, we test RSI in r…
View article: Supplementary Tables 1 - 2 from Validation of a Radiosensitivity Molecular Signature in Breast Cancer
Supplementary Tables 1 - 2 from Validation of a Radiosensitivity Molecular Signature in Breast Cancer Open
PDF file, 81K, Online Table 1. Clinical Characteristics of Patients in Both Datasets. Online Table 2. Distribution of Recurrences by Group (Karolinka Dataset).
View article: Data from Validation of a Radiosensitivity Molecular Signature in Breast Cancer
Data from Validation of a Radiosensitivity Molecular Signature in Breast Cancer Open
Purpose: Previously, we developed a radiosensitivity molecular signature [radiosensitivity index (RSI)] that was clinically validated in 3 independent datasets (rectal, esophageal, and head and neck) in 118 patients. Here, we test RSI in r…
View article: Supplementary Tables 1 - 2 from Validation of a Radiosensitivity Molecular Signature in Breast Cancer
Supplementary Tables 1 - 2 from Validation of a Radiosensitivity Molecular Signature in Breast Cancer Open
PDF file, 81K, Online Table 1. Clinical Characteristics of Patients in Both Datasets. Online Table 2. Distribution of Recurrences by Group (Karolinka Dataset).
View article: Complex geodesics in de Sitter space
Complex geodesics in de Sitter space Open
The two-point function of a free massive scalar field on a fixed background can be evaluated in the large mass limit by using a semiclassical geodesic approximation. In de Sitter space, however, this poses a puzzle. Certain spacelike separ…
View article: Interpolating geometries and the stretched dS$_2$ horizon
Interpolating geometries and the stretched dS$_2$ horizon Open
We investigate dilaton-gravity models whose solutions contain a large portion of the static patch of dS$_2$. The thermodynamic properties of these theories are considered both in the presence of a finite Dirichlet wall, as well as for asym…
View article: Abdominopelvic MR to CT registration using a synthetic CT intermediate
Abdominopelvic MR to CT registration using a synthetic CT intermediate Open
Accurate coregistration of computed tomography (CT) and magnetic resonance (MR) imaging can provide clinically relevant and complementary information and can serve to facilitate multiple clinical tasks including surgical and radiation trea…
View article: Navigator-assisted hypofractionation (NAVAH) to address radiation therapy access disparities facing African-Americans with breast cancer
Navigator-assisted hypofractionation (NAVAH) to address radiation therapy access disparities facing African-Americans with breast cancer Open
This is the first study to investigate the impact of patient navigation on reducing RT access disparities facing African-American breast cancer patients. The natural progression of this work will be to expand this model to include addition…
View article: Effect of applicator removal from target volume for cervical cancer patients treated with Venezia high-dose-rate brachytherapy applicator
Effect of applicator removal from target volume for cervical cancer patients treated with Venezia high-dose-rate brachytherapy applicator Open
Venezia applicator with vaginal caps has significant impact on small volume and high-dose DVH parameters of the target. Applicator contour exclusion is recommended for dosimetric evaluation when Venezia applicator is used.
View article: Lower tumor mutational burden (TMB) and hepatic metastases may predict for lack of response to PD-1 blockade in MSI-H metastatic colorectal cancer (MCRC)
Lower tumor mutational burden (TMB) and hepatic metastases may predict for lack of response to PD-1 blockade in MSI-H metastatic colorectal cancer (MCRC) Open
Background: MCRC with microsatellite instability (MSI-H) are associated with cytotoxic lymphocytic infiltration that is counterbalanced by multiple checkpoints. Several prospective clinical trials in chemotherapy-resistant MSI-H MCRC have …
View article: Precision Medicine for Breast Cancer: The Paths to Truly Individualized Diagnosis and Treatment
Precision Medicine for Breast Cancer: The Paths to Truly Individualized Diagnosis and Treatment Open
Precision medicine in oncology seeks to individualize each patient’s treatment regimen based on an accurate assessment of the risk of recurrence or progression of that person’s cancer. Precision will be achieved at each phase of care, from…
View article: Intraoperative Radiotherapy for Breast Cancer
Intraoperative Radiotherapy for Breast Cancer Open
Intraoperative radiotherapy (IORT) for early stage breast cancer is a technique for partial breast irradiation. There are several technologies in clinical use to perform breast IORT. Regardless of technique, IORT generally refers to the de…