Elizabeth C. Rosser
YOU?
Author Swipe
View article: Spatially resolved fetal and maternal cell contributions to severe Preeclampsia
Spatially resolved fetal and maternal cell contributions to severe Preeclampsia Open
Summary The molecular and cellular pathophysiology of the fetal-maternal interface in preeclamsia remains poorly understood, but it is increasingly clear that both fetus and mother make independent contributions to it. Here, we spatially d…
View article: Synovial tissue atlas in juvenile idiopathic arthritis reveals pathogenic niches associated with disease severity
Synovial tissue atlas in juvenile idiopathic arthritis reveals pathogenic niches associated with disease severity Open
Precision application of targeted therapies is urgently needed to improve long-term clinical outcomes for children affected by inflammatory arthritis, known as juvenile idiopathic arthritis (JIA). Progress has been hampered by our limited …
View article: OP0371 Transcriptomic analysis of transgender adolescents undergoing gender-affirming sex hormone therapy reveals sex-specific mechanisms associated with female childhood-onset SLE
OP0371 Transcriptomic analysis of transgender adolescents undergoing gender-affirming sex hormone therapy reveals sex-specific mechanisms associated with female childhood-onset SLE Open
View article: OP0252 A MULTIMODAL DISSECTION OF SPATIAL TISSUE NICHES ASSOCIATED WITH SEVERITY IN CHILDHOOD ARTHRITIS
OP0252 A MULTIMODAL DISSECTION OF SPATIAL TISSUE NICHES ASSOCIATED WITH SEVERITY IN CHILDHOOD ARTHRITIS Open
View article: TYPE I INTERFERON AND MITOCHONDRIAL DYSFUNCTION ARE ASSOCIATED WITH DYSREGULATED CYTOTOXIC CD8+ T CELL RESPONSES IN JUVENILE SYSTEMIC LUPUS ERYTHEMATOSUS
TYPE I INTERFERON AND MITOCHONDRIAL DYSFUNCTION ARE ASSOCIATED WITH DYSREGULATED CYTOTOXIC CD8+ T CELL RESPONSES IN JUVENILE SYSTEMIC LUPUS ERYTHEMATOSUS Open
PV001 / #50 Poster Topic: AS01 - Adaptive Immunity Background/Purpose Juvenile systemic lupus erythematosus (JSLE) is an autoimmune condition which causes significant morbidity in children and young adults. While many aspects of immune dys…
View article: Identification and validation of interferon-driven gene signature as a predictor of response to methotrexate in juvenile idiopathic arthritis
Identification and validation of interferon-driven gene signature as a predictor of response to methotrexate in juvenile idiopathic arthritis Open
In children with JIA, a high IFN-driven gene signature is associated with a better response to MTX than those with a low IFN-driven gene signature. These data could pave the way to clinically validated tools to identify those most likely t…
View article: Estrogen influences class-switched memory B cell frequency only in humans with two X chromosomes
Estrogen influences class-switched memory B cell frequency only in humans with two X chromosomes Open
Sex differences in immunity are well-documented, though mechanisms underpinning these differences remain ill-defined. Here, in a human-only ex vivo study, we demonstrate that postpubertal cisgender females have higher levels of CD19+CD27+I…
View article: Treg fitness signatures as a biomarker for disease activity in Juvenile Idiopathic Arthritis
Treg fitness signatures as a biomarker for disease activity in Juvenile Idiopathic Arthritis Open
Juvenile Idiopathic Arthritis (JIA) is an autoimmune condition characterised by flares of joint inflammation. However, no reliable biomarker exists to predict the erratic disease course. Normally, regulatory T cells (Tregs) maintain tolera…
View article: Type I interferon and mitochondrial dysfunction are associated with dysregulated cytotoxic CD8+ T cell responses in juvenile systemic lupus erythematosus
Type I interferon and mitochondrial dysfunction are associated with dysregulated cytotoxic CD8+ T cell responses in juvenile systemic lupus erythematosus Open
Juvenile systemic lupus erythematosus (JSLE) is an autoimmune condition which causes significant morbidity in children and young adults and is more severe in its presentation than adult-onset SLE. While many aspects of immune dysfunction h…
View article: Oestrogen influences B cell class-switching in individuals with an XX sex chromosome complement
Oestrogen influences B cell class-switching in individuals with an XX sex chromosome complement Open
Sex differences in humoral immunity are well-documented, though the mechanisms underpinning these differences remain ill-defined. Here, we demonstrate that post-pubertal cisgender females have higher levels of class-switched B cells compar…
View article: Active juvenile systemic lupus erythematosus is associated with distinct NK cell transcriptional and phenotypic alterations
Active juvenile systemic lupus erythematosus is associated with distinct NK cell transcriptional and phenotypic alterations Open
View article: Treg fitness as a biomarker for disease activity in Juvenile Idiopathic Arthritis
Treg fitness as a biomarker for disease activity in Juvenile Idiopathic Arthritis Open
Juvenile Idiopathic Arthritis (JIA) is an autoimmune condition characterised by persistent flares of joint inflammation. However, no reliable biomarker exists to predict the erratic disease course. Normally, regulatory T cells (Tregs) main…
View article: Phytosterols in human serum as measured using a liquid chromatography tandem mass spectrometry
Phytosterols in human serum as measured using a liquid chromatography tandem mass spectrometry Open
Phytosterols are lipophilic compounds found in plants with structural similarity to mammalian cholesterol. They cannot be endogenously produced by mammals and therefore always originate from diet. There has been increased interest in dieta…
View article: Phytosterols in human serum as measured using a liquid chromatography tandem mass spectrometry
Phytosterols in human serum as measured using a liquid chromatography tandem mass spectrometry Open
Phytosterols are lipophilic compounds found in plants with structural similarity to mammalian cholesterol. They cannot be endogenously produced by mammals and therefore always originate from diet. There has been increased interest in dieta…
View article: Phytosterols in human serum as measured using a liquid chromatography tandem mass spectrometry
Phytosterols in human serum as measured using a liquid chromatography tandem mass spectrometry Open
Phytosterols are lipophilic compounds found in plants with structural similarity to mammalian cholesterol. They cannot be endogenously produced by mammals and therefore always originate from diet. There has been increased interest in dieta…
View article: Development and implementation of ‘A guide to PPIE – Early Integration into Research Proposals’ in a multi-disciplinary consortium
Development and implementation of ‘A guide to PPIE – Early Integration into Research Proposals’ in a multi-disciplinary consortium Open
Journal Article Corrected proof Development and implementation of 'A guide to PPIE – Early Integration into Research Proposals' in a multi-disciplinary consortium Get access Richard Beesley, Richard Beesley Juvenile Arthritis Research, Ton…
View article: Distinct B cell profiles characterise healthy weight and obesity pre- and post-bariatric surgery
Distinct B cell profiles characterise healthy weight and obesity pre- and post-bariatric surgery Open
View article: Role of CD14+ monocyte-derived oxidised mitochondrial DNA in the inflammatory interferon type 1 signature in juvenile dermatomyositis
Role of CD14+ monocyte-derived oxidised mitochondrial DNA in the inflammatory interferon type 1 signature in juvenile dermatomyositis Open
View article: Cytokine production by human B cells: role in health and autoimmune disease
Cytokine production by human B cells: role in health and autoimmune disease Open
B cells are classically considered solely as antibody-producing cells driving humoral immune responses to foreign antigens in infections and vaccinations as well as self-antigens in pathological settings such as autoimmunity. However, it h…
View article: B cell contribution to immunometabolic dysfunction and impaired immune responses in obesity
B cell contribution to immunometabolic dysfunction and impaired immune responses in obesity Open
Summary Obesity increases the risk of type 2 diabetes mellitus, cardiovascular disease, fatty liver disease, and cancer. It is also linked with more severe complications from infections, including COVID-19, and poor vaccine responses. Chro…
View article: Gender-Diverse Inclusion in Immunological Research: Benefits to Science and Health
Gender-Diverse Inclusion in Immunological Research: Benefits to Science and Health Open
The differences between male and female immune systems are an under-researched field, ripe for discovery. This is evidenced by the stark sex biases seen in autoimmunity and infectious disease. Both the sex hormones (oestrogen and testoster…
View article: Mini-Review: Gut-Microbiota and the Sex-Bias in Autoimmunity – Lessons Learnt From Animal Models
Mini-Review: Gut-Microbiota and the Sex-Bias in Autoimmunity – Lessons Learnt From Animal Models Open
It is well appreciated that there is a female preponderance in the development of most autoimmune diseases. Thought to be due to a complex interplay between sex chromosome complement and sex-hormones, however, the exact mechanisms underlyi…
View article: ‘B cells, where do they get their energy from!?’ New insights into immunometabolism in the pathogenesis of systemic lupus erythematosus
‘B cells, where do they get their energy from!?’ New insights into immunometabolism in the pathogenesis of systemic lupus erythematosus Open
View article: Favorable antibody responses to human coronaviruses in children and adolescents with autoimmune rheumatic diseases
Favorable antibody responses to human coronaviruses in children and adolescents with autoimmune rheumatic diseases Open
View article: Biomarkers Associated with Organ-Specific Involvement in Juvenile Systemic Lupus Erythematosus
Biomarkers Associated with Organ-Specific Involvement in Juvenile Systemic Lupus Erythematosus Open
Juvenile systemic lupus erythematosus (JSLE) is characterised by onset before 18 years of age and more severe disease phenotype, increased morbidity and mortality compared to adult-onset SLE. Management strategies in JSLE rely heavily on e…
View article: The emerging field of regulatory B cell immunometabolism
The emerging field of regulatory B cell immunometabolism Open
View article: Intestinal barrier dysfunction plays an integral role in arthritis pathology and can be targeted to ameliorate disease
Intestinal barrier dysfunction plays an integral role in arthritis pathology and can be targeted to ameliorate disease Open
View article: A systematic review exploring the bidirectional relationship between puberty and autoimmune rheumatic diseases
A systematic review exploring the bidirectional relationship between puberty and autoimmune rheumatic diseases Open
Background Autoimmune rheumatic diseases (ARDs) are associated with a significant sex-bias, which becomes more evident post-puberty. This systematic review aims to elucidate the bidirectional relationship between puberty and ARD-related ou…
View article: Exploring the Evidence for an Immunomodulatory Role of Vitamin D in Juvenile and Adult Rheumatic Disease
Exploring the Evidence for an Immunomodulatory Role of Vitamin D in Juvenile and Adult Rheumatic Disease Open
Vitamin D is synthesized in the skin following exposure to UVB radiation or is directly absorbed from the diet. Following hydroxylation in the liver and kidneys, vitamin D becomes its bioactive form, 1,25(OH) 2 D, which has been described …
View article: Favourable antibody responses to human coronaviruses in children and adolescents with autoimmune rheumatic diseases
Favourable antibody responses to human coronaviruses in children and adolescents with autoimmune rheumatic diseases Open
Differences in humoral immunity to coronaviruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), between children and adults remain unexplained and the impact of underlying immune dysfunction or suppression unknown…