Elizabeth Finnie
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View article: The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube
The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube Open
The vertebrate neural tube generates a large diversity of molecularly and functionally distinct neurons and glia from a small progenitor pool. While the role of spatial patterning in organizing cell fate specification has been extensively …
View article: Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data
Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data Open
SUMMARY Building a mechanistic understanding of cell fate decisions remains a fundamental goal of developmental biology, with implications for stem cell therapies, regenerative medicine and understanding disease mechanisms. Single-cell tra…
View article: Predictable Engineering of Signal-Dependent Cis-Regulatory Elements
Predictable Engineering of Signal-Dependent Cis-Regulatory Elements Open
Cis-regulatory elements (CREs) control how genes respond to external signals, but the principles governing their structure and function remain poorly understood. While differential transcription factor binding is known to regulate gene exp…