Kristin Burnum-Johnson
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View article: mGem: Revisiting bacterial overflow metabolism
mGem: Revisiting bacterial overflow metabolism Open
Bacterial overflow metabolism, where cells perform oxidative fermentation despite the availability of ample oxygen and carbon sources, remains a long-standing paradox in microbial metabolism. Traditional explanations attribute this phenome…
View article: Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East respiratory syndrome coronavirus disease severity
Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East respiratory syndrome coronavirus disease severity Open
Coronaviruses (CoV) emerge suddenly from animal reservoirs to cause novel diseases in new hosts. Discovered in 2012, the Middle East respiratory syndrome coronavirus (MERS-CoV) is endemic in camels in the Middle East and is continually cau…
View article: Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East respiratory syndrome coronavirus disease severity
Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East respiratory syndrome coronavirus disease severity Open
Coronaviruses (CoV) emerge suddenly from animal reservoirs to cause novel diseases in new hosts. Discovered in 2012, the Middle East respiratory syndrome coronavirus (MERS-CoV) is endemic in camels in the Middle East and is continually cau…
View article: Deciphering ApoE Genotype-Driven Proteomic and Lipidomic Alterations in Alzheimer’s Disease Across Distinct Brain Regions
Deciphering ApoE Genotype-Driven Proteomic and Lipidomic Alterations in Alzheimer’s Disease Across Distinct Brain Regions Open
Alzheimer's disease (AD) is a neurodegenerative disease with a complex etiology influenced by confounding factors such as genetic polymorphisms, age, sex, and race. Traditionally, AD research has not prioritized these influences, resulting…
View article: Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East Respiratory Syndrome coronavirus disease severity
Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East Respiratory Syndrome coronavirus disease severity Open
Coronaviruses (CoV) emerge suddenly from animal reservoirs to cause novel diseases in new hosts. Discovered in 2012, Middle East respiratory syndrome coronavirus (MERS-CoV) is endemic in camels in the Middle East and is continually causing…
View article: Coupling Microdroplet-Based Sample Preparation, Multiplexed Isobaric Labeling, and Nanoflow Peptide Fractionation for Deep Proteome Profiling of the Tissue Microenvironment
Coupling Microdroplet-Based Sample Preparation, Multiplexed Isobaric Labeling, and Nanoflow Peptide Fractionation for Deep Proteome Profiling of the Tissue Microenvironment Open
There is increasing interest in developing in-depth proteomic approaches for mapping tissue heterogeneity in a cell-type-specific manner to better understand and predict the function of complex biological systems such as human organs. Exis…
View article: Changes in maternal blood and placental lipidomic profile in obesity and gestational diabetes: Evidence for sexual dimorphism
Changes in maternal blood and placental lipidomic profile in obesity and gestational diabetes: Evidence for sexual dimorphism Open
Introduction Obesity and gestational diabetes (GDM) are associated with adverse pregnancy outcomes and program the offspring for cardiometabolic disease in a sexually dimorphic manner. The placenta transfers lipids to the fetus and uses th…
View article: PeakQC: A Software Tool for Omics-Agnostic Automated Quality Control of Mass Spectrometry Data
PeakQC: A Software Tool for Omics-Agnostic Automated Quality Control of Mass Spectrometry Data Open
Mass spectrometry is broadly employed to study complex molecular mechanisms in various biological and environmental fields, enabling 'omics' research such as proteomics, metabolomics, and lipidomics. As study cohorts grow larger and more c…
View article: The impact of heat stress on the human plasma lipidome
The impact of heat stress on the human plasma lipidome Open
The year of 2023 displayed the highest average global temperatures since it has been recorded—the duration and severity of extreme heat are projected to increase. Rising global temperatures represent a major public health threat, especiall…
View article: A fast and sensitive size‐exclusion chromatography method for plasma extracellular vesicle proteomic analysis
A fast and sensitive size‐exclusion chromatography method for plasma extracellular vesicle proteomic analysis Open
Extracellular vesicles (EVs) carry diverse biomolecules derived from their parental cells, making their components excellent biomarker candidates. However, purifying EVs is a major hurdle in biomarker discovery since current methods requir…
View article: The impact of heat stress on the human plasma lipidome
The impact of heat stress on the human plasma lipidome Open
The year of 2023 displayed the highest average global temperatures since it has been recorded—the duration and severity of extreme heat are projected to increase. Rising global temperatures represent a major public health threat, especiall…
View article: Mapping Microhabitats: Metabolome Informed Proteome Imaging of Lignocellulose Decomposition by a Naturally Evolved Microbial Consortium
Mapping Microhabitats: Metabolome Informed Proteome Imaging of Lignocellulose Decomposition by a Naturally Evolved Microbial Consortium Open
The annotated protein database was curated to annotate MS/MS data in the manuscript titled 'Mapping Microhabitats: Metabolome Informed Proteome Imaging of Lignocellulose Decomposition by a Naturally Evolved Microbial Consortium'.
View article: Computational tools and algorithms for ion mobility spectrometry‐mass spectrometry
Computational tools and algorithms for ion mobility spectrometry‐mass spectrometry Open
Ion mobility spectrometry‐mass spectrometry (IMS‐MS or IM‐MS) is a powerful analytical technique that combines the gas‐phase separation capabilities of IM with the identification and quantification capabilities of MS. IM‐MS can differentia…
View article: Agilent AgileBioFoundry CRADA
Agilent AgileBioFoundry CRADA Open
NTESS, LBNL, PNNL, and Agilent are collaborating to expand a prototype system that processes hundreds of samples per day by UHPLC-QTOF mass spectrometric-based target methods for both metabolomic and proteomic application sin support the n…
View article: A fast and sensitive size-exclusion chromatography method for plasma extracellular vesicle proteomic analysis
A fast and sensitive size-exclusion chromatography method for plasma extracellular vesicle proteomic analysis Open
Extracellular vesicles (EVs) carry diverse biomolecules derived from their parental cells, making their components excellent biomarker candidates. However, purifying EVs is a major hurdle in biomarker discovery since current methods requir…
View article: Deciphering ApoE Genotype-Driven Proteomic and Lipidomic Alterations in Alzheimer’s Disease Across Distinct Brain Regions
Deciphering ApoE Genotype-Driven Proteomic and Lipidomic Alterations in Alzheimer’s Disease Across Distinct Brain Regions Open
Alzheimer's disease (AD) is a neurodegenerative disease with a complex etiology influenced by confounding factors such as genetic polymorphisms, age, sex, and race. Traditionally, AD research has not prioritized these influences, resulting…