Sharon E. Mace
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View article: Clinical validation of an AI-based blood testing device for diagnosis and prognosis of acute infection and sepsis
Clinical validation of an AI-based blood testing device for diagnosis and prognosis of acute infection and sepsis Open
Lack of reliable diagnostics for the presence, type and severity of infection in patients presenting to emergency departments with non-specific symptoms poses considerable challenges. We developed TriVerity, which uses isothermal amplifica…
View article: A comparison of magnetocardiography with noninvasive cardiac testing in the evaluation of patients with chest pain
A comparison of magnetocardiography with noninvasive cardiac testing in the evaluation of patients with chest pain Open
MCG is a rapid, safe, effective, painless and radiation-free test, does not require contrast/medication administration. MCG by avoiding provocative medications and/or exercise eliminates the risk of provoking myocardial injury and causing …
View article: Procedural Sedation in the Emergency Department – An Observational Study: Does Nil Per Os Status Matter?
Procedural Sedation in the Emergency Department – An Observational Study: Does Nil Per Os Status Matter? Open
Introduction: Procedural sedation (PS) is commonly performed in the emergency department (ED). Nil per os (nothing by mouth) (NPO) guidelines extrapolated from standards for patients undergoing elective procedures in the operating room hav…
View article: D-dimer Levels in Acute, Medically Ill, Hospitalized Patients: A Large, Prospective, Multicenter Study in the United States
D-dimer Levels in Acute, Medically Ill, Hospitalized Patients: A Large, Prospective, Multicenter Study in the United States Open
Background The study's main aim was to determine the prevalence of elevated D-dimer levels in adult patients hospitalized for acute medical illnesses not suspected to have venous thromboembolism (VTE). The secondary aims were to determine …
View article: Rapid and Accurate Diagnosis and Prognosis of Acute Infections and Sepsis from Whole Blood Using Host Response mRNA amplification and Result Interpretation by Machine-Learning Classifiers
Rapid and Accurate Diagnosis and Prognosis of Acute Infections and Sepsis from Whole Blood Using Host Response mRNA amplification and Result Interpretation by Machine-Learning Classifiers Open
Many patients in the emergency department present with signs and symptoms that arouse concern for sepsis; however, other explanations are also possible. There are currently no rapid tests used in clinical practice that reliably distinguish…
View article: National cost savings, operational and safety benefits from use of magnetocardiography in the assessment of emergency department chest pain patients
National cost savings, operational and safety benefits from use of magnetocardiography in the assessment of emergency department chest pain patients Open
If adopted widely and used consistently, an MCG-first strategy among eligible patients could yield substantial benefits by averting avoidable cardiac diagnostic testing.
View article: Accelerated magnetocardiography in the evaluation of patients with suspected cardiac ischemia: The MAGNETO trial
Accelerated magnetocardiography in the evaluation of patients with suspected cardiac ischemia: The MAGNETO trial Open
MCG provides similar sensitivity and lower specificity as non-invasive stress testing in ED sACS patients. Time to test is shorter for MCG with higher patient satisfaction scores.
View article: The Case for Observation Medicine Education and Training in Emergency Medicine
The Case for Observation Medicine Education and Training in Emergency Medicine Open
Background Many hospitals have or will be opening an observation unit (OU), the majority managed by the emergency department (ED). Graduating emergency medicine (EM) residents will be expected to have the knowledge and skills necessary to …
View article: <p>ATHENA: A Phase 3, Open-Label Study Of The Safety And Effectiveness Of Oliceridine (TRV130), A G-Protein Selective Agonist At The μ-Opioid Receptor, In Patients With Moderate To Severe Acute Pain Requiring Parenteral Opioid Therapy</p>
ATHENA: A Phase 3, Open-Label Study Of The Safety And Effectiveness Of Oliceridine (TRV130), A G-Protein Selective Agonist At The μ-Opioid Receptor, In Patients With Moderate To Severe Acute Pain Requiring Parenteral Opioid Therapy Open
NCT02656875.
View article: Reviewing Disasters: Hospital Evacuations in the United States from 2000 to 2017
Reviewing Disasters: Hospital Evacuations in the United States from 2000 to 2017 Open
Introduction: Between 2000 to 2017, there were over 150 hospital evacuations in the United States. Data received from approximately 35 states were primarily concentrated in California, Florida, and Texas. This analysis will provide disaste…
View article: Caring for the Vulnerable Geriatric Individual in a Disaster
Caring for the Vulnerable Geriatric Individual in a Disaster Open
Introduction: The elderly have the highest rates of morbidity/mortality in a disaster and are therefore the most vulnerable. 50% of deaths in Hurricane Katrina were ≥75 years old. In the California wildfires, most deaths were people in the…
View article: Challenges in Dealing with Supervised and Institutionalized Populations in a Disaster
Challenges in Dealing with Supervised and Institutionalized Populations in a Disaster Open
Introduction: Those residing in supervised facilities including nursing homes, mental health facilities, group homes, and penal institutions for health, legal, or security reasons present unique challenges in a disaster. Methods: A review …
View article: Mortality in Nursing Home Evacuations in the United States from 1995-2017
Mortality in Nursing Home Evacuations in the United States from 1995-2017 Open
Introduction: There are an estimated 15,600 nursing homes with a total of 1.4 million residents in the United States. The number of residents will continue to increase due to the aging population, and the associated morbidities will make i…
View article: Social Media in Disasters
Social Media in Disasters Open
Introduction: Individuals may not receive messages via usual sources. Social media such as Facebook, LinkedIn, Twitter and social networking groups have been useful in the notification, information dissemination, safe notices, and reunific…