Elizabeth S. McDonald
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View article: Dynamic AI-assisted ipsilateral tissue matching for digital breast tomosynthesis
Dynamic AI-assisted ipsilateral tissue matching for digital breast tomosynthesis Open
AI-assisted tissue matching significantly improved localization accuracy, especially for non- expert readers and in complex cases. The AI warning system effectively identified high-uncertainty cases. Errors were reduced to within typical t…
View article: Dual-Tracer Imaging on a Long–Axial-Field-of-View PET: A Proof-of-Principle Study with [<sup>18</sup>F]FGln and [<sup>18</sup>F]FDG
Dual-Tracer Imaging on a Long–Axial-Field-of-View PET: A Proof-of-Principle Study with [<sup>18</sup>F]FGln and [<sup>18</sup>F]FDG Open
Current protocols necessitate imaging 2 18F-labeled tracers in separate sessions. Herein, we report on the development and testing of a protocol that sequentially images 2 18F-labeled tracers-18F-(2S,
View article: Supplemental Figure S1 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Supplemental Figure S1 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence Open
This shows PGRMC1 expression is increased in ER-, PR-, and triple negative human breast cancers.
View article: Supplemental Table S5 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Supplemental Table S5 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence Open
This shows the association of our proliferation score with established scores like Oncotype Dx and PAM50.
View article: Supplemental Table S4 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Supplemental Table S4 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence Open
This shows the upstream regulators with significant number of targets correlated with PGRMC1
View article: Supplementary Figure S3 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Supplementary Figure S3 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence Open
This shows that TK1 is associated with early breast cancer relapse.
View article: Supplemental Table S1 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Supplemental Table S1 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence Open
These are the publicly available microarray datasets combined for this analysis.
View article: Supplemental Figure S5 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Supplemental Figure S5 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence Open
Supplemental Figure S5
View article: Supplemental Figure S4 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Supplemental Figure S4 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence Open
This shows that the association of TK1 with breast cancer relapse is dependent on proliferation.
View article: Supplemental Figure S2 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Supplemental Figure S2 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence Open
This shows the association of TK1 with early breast cancer relapse segregated by molecular subtype.
View article: Supplemental Table S2 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Supplemental Table S2 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence Open
This shows the number of samples with available data for analysis.
View article: Supplemental Table S6 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Supplemental Table S6 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence Open
This shows the trimeric complex correlation with PAM50 ROR.
View article: Supplemental Table S3 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Supplemental Table S3 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence Open
The shows the number of samples with RNA-sequencing data available from the TCGA database.
View article: [18F]FluorThanatrace PET imaging as a biomarker of response to PARP inhibitors in breast cancer
[18F]FluorThanatrace PET imaging as a biomarker of response to PARP inhibitors in breast cancer Open
These early results suggest the potential of [18F]FTT-PET to select patients for PARPi treatment and monitor in vivo pharmacodynamics after therapy start. Absence of association with HRD scores supports [18F]FTT uptak…
View article: Figure 1 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Figure 1 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence Open
A, PGRMC1 is overexpressed in human breast cancers of the basal subtype using PAM50. TMEM97 has the highest expression in luminal B tumors. B, PGRMC1 is overexpressed in hormone receptor–negative cancers. LDLR expression is h…
View article: Supplemental Table S5 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Supplemental Table S5 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence Open
This shows the association of our proliferation score with established scores like Oncotype Dx and PAM50.
View article: Data from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Data from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence Open
The ternary complex of progesterone receptor membrane component 1 (PGRMC1)–sigma-2 receptor/transmembrane protein 97 (σ2R/TMEM97)–low-density lipoprotein receptor (LDLR) has recently been discovered and plays a role in cholesterol transpor…
View article: Supplemental Table S6 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Supplemental Table S6 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence Open
This shows the trimeric complex correlation with PAM50 ROR.
View article: Supplemental Figure S4 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Supplemental Figure S4 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence Open
This shows that the association of TK1 with breast cancer relapse is dependent on proliferation.
View article: Supplementary Figure S3 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Supplementary Figure S3 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence Open
This shows that TK1 is associated with early breast cancer relapse.
View article: Supplemental Figure S2 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Supplemental Figure S2 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence Open
This shows the association of TK1 with early breast cancer relapse segregated by molecular subtype.
View article: Supplemental Figure S1 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Supplemental Figure S1 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence Open
This shows PGRMC1 expression is increased in ER-, PR-, and triple negative human breast cancers.
View article: Table 1 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Table 1 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence Open
Association of PGRMC1, TK1, LDLR, and TMEM97 with proliferation. Meta-analysis was performed to examine the association among a) PGRMC1, b) TMEM97, c) TK1, and d) LDLR and estimated proliferation rates of tumors
View article: Supplemental Table S2 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Supplemental Table S2 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence Open
This shows the number of samples with available data for analysis.
View article: Supplemental Table S4 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Supplemental Table S4 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence Open
This shows the upstream regulators with significant number of targets correlated with PGRMC1
View article: Table 2 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Table 2 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence Open
PGRMC1 is weakly associated with TK1. PGRMC1 exhibits a significant correlation with TK1 when all cancers are combined, although the magnitude of these associations is weak. PGRMC1 vs. TK1
View article: Supplemental Figure S5 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Supplemental Figure S5 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence Open
Supplemental Figure S5
View article: Supplemental Table S3 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Supplemental Table S3 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence Open
The shows the number of samples with RNA-sequencing data available from the TCGA database.
View article: Figure 2 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Figure 2 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence Open
PGRMC1 is associated with early breast cancer relapse in a proliferation-dependent manner. Effect size estimates were aggregated across datasets by meta-analysis to determine the risk of relapse within 5 years from all cancers. A, A…
View article: Figure 4 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Figure 4 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence Open
PAM50, derived Oncotype DX, and a new proliferation score (Prolif224) were all similarly related to RFS. JRH, John Radcliffe Hospital; RFS, recurrence-free survival.