Elizabeth Theusch
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View article: <i>MIR192</i> Upregulates GLP-1 Receptor and Improves Statin-Induced Impairment of Insulin Secretion
<i>MIR192</i> Upregulates GLP-1 Receptor and Improves Statin-Induced Impairment of Insulin Secretion Open
Statins are a commonly prescribed cholesterol lowering drug class that can increase the risk of new-onset diabetes (NOD). To investigate the molecular mechanisms underlying this effect, we generated human induced pluripotent stem cells (iP…
View article: Predicting Metabolic Dysfunction Associated Steatotic Liver Disease Risk Using Patient-Derived Induced Pluripotent Stem Cells
Predicting Metabolic Dysfunction Associated Steatotic Liver Disease Risk Using Patient-Derived Induced Pluripotent Stem Cells Open
Background and Aims Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) is reversible at early stages, making early identification of high-risk individuals clinically valuable. Previously, we demonstrated that patient-derived …
View article: Loss of TMEM55B modulates lipid metabolism through dysregulated lipophagy and mitochondrial function
Loss of TMEM55B modulates lipid metabolism through dysregulated lipophagy and mitochondrial function Open
Lipophagy is a form of selective autophagy that targets the lipid droplets for lysosomal decay and has been implicated in the onset and progression of metabolic dysfunction-associated steatotic liver disease (MASLD). Factors that augment l…
View article: TOMM40 regulates hepatocellular and plasma lipid metabolism via an LXR-dependent pathway
TOMM40 regulates hepatocellular and plasma lipid metabolism via an LXR-dependent pathway Open
These findings demonstrate a role for TOMM40 in regulating hepatic lipid and plasma lipoprotein levels and identify mechanisms linking mitochondrial function with lipid metabolism.
View article: Pharmacogenomics of CRP response to statins: a GIST consortium study
Pharmacogenomics of CRP response to statins: a GIST consortium study Open
Introduction Statins are first line treatments in the primary and secondary prevention of cardiovascular disease. Prior clinical studies have shown that statins act independently of lipid lowering mechanisms to decrease C-reactive protein …
View article: X chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction
X chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction Open
Statin drugs lower blood cholesterol levels for cardiovascular disease prevention. Women are more likely than men to experience adverse statin effects, particularly new-onset diabetes (NOD) and muscle weakness. Here we find that impaired g…
View article: TOMM40 regulates hepatocellular and plasma lipid metabolism via an LXR-dependent pathway
TOMM40 regulates hepatocellular and plasma lipid metabolism via an LXR-dependent pathway Open
The gene encoding TOMM40 (Transporter of Outer Mitochondrial Membrane 40) is adjacent to that encoding APOE, which has a central role in lipid and lipoprotein metabolism. Human genetic variants near APOE and TOMM40 are strongly associated …
View article: TOMM40 and TOMM22 of the Translocase Outer Mitochondrial Membrane Complex rescue statin-impaired mitochondrial dynamics, morphology, and mitophagy in skeletal myotubes
TOMM40 and TOMM22 of the Translocase Outer Mitochondrial Membrane Complex rescue statin-impaired mitochondrial dynamics, morphology, and mitophagy in skeletal myotubes Open
Background Statins are the drugs most commonly used for lowering plasma low-density lipoprotein (LDL) cholesterol levels and reducing cardiovascular disease risk. Although generally well tolerated, statins can induce myopathy, a major caus…
View article: Participant-derived cell line transcriptomic analyses and mouse studies reveal a role for ZNF335 in plasma cholesterol statin response
Participant-derived cell line transcriptomic analyses and mouse studies reveal a role for ZNF335 in plasma cholesterol statin response Open
Background Statins lower circulating low-density lipoprotein cholesterol (LDLC) levels and reduce cardiovascular disease risk. Though highly efficacious in general, there is considerable inter-individual variation in statin efficacy that r…
View article: The Pharmacogenetics of Statin Therapy on Clinical Events: No Evidence that Genetic Variation Affects Statin Response on Myocardial Infarction
The Pharmacogenetics of Statin Therapy on Clinical Events: No Evidence that Genetic Variation Affects Statin Response on Myocardial Infarction Open
Background: The pharmacogenetic effect on cardiovascular disease reduction in response to statin treatment has only been assessed in small studies. In a pharmacogenetic genome wide association study (GWAS) analysis within the Genomic Inves…
View article: Undifferentiated Induced Pluripotent Stem Cells as a Genetic Model for Nonalcoholic Fatty Liver Disease
Undifferentiated Induced Pluripotent Stem Cells as a Genetic Model for Nonalcoholic Fatty Liver Disease Open
Patient-derived induced pluripotent stem cells (iPSCs) have been transformational in biomedical research for their ability to differentiate into any cell type while retaining the genetic information of the donor individual, for example iPS…
View article: Summary Statistics from "Meta-GWAS of PCSK9 levels detects two novel loci at APOB and TM6SF2"
Summary Statistics from "Meta-GWAS of PCSK9 levels detects two novel loci at APOB and TM6SF2" Open
GWAMA summary statistics of PCSK9 levels using fixed-effect model. Genome-wide data is given for Europeans with statin adjustment and Europeans without statin treatment only (subset of the population). In addition, locus-wide data of the P…
View article: Summary Statistics from "Meta-GWAS of PCSK9 levels detects two novel loci at APOB and TM6SF2"
Summary Statistics from "Meta-GWAS of PCSK9 levels detects two novel loci at APOB and TM6SF2" Open
GWAMA summary statistics of PCSK9 levels using fixed-effect model. Genome-wide data is given for Europeans with statin adjustment and Europeans without statin treatment only (subset of the population). In addition, locus-wide data of the P…
View article: Summary Statistics from "Meta-GWAS of PCSK9 levels detects two novel loci at APOB and TM6SF2"
Summary Statistics from "Meta-GWAS of PCSK9 levels detects two novel loci at APOB and TM6SF2" Open
GWAMA summary statistics of PCSK9 levels using fixed-effect model. Genome-wide data is given for Europeans with statin adjustment and Europeans without statin treatment only (subset of the population). In addition, locus-wide data of the P…
View article: Meta-GWAS of PCSK9 levels detects two novel loci at<i>APOB</i>and<i>TM6SF2</i>
Meta-GWAS of PCSK9 levels detects two novel loci at<i>APOB</i>and<i>TM6SF2</i> Open
Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key player in lipid metabolism, as it degrades low-density lipoprotein (LDL) receptors from hepatic cell membranes. So far, only variants of the PCSK9 gene locus were fo…
View article: Identifying Genetic Modulators of Statin Response Using Subject-Derived Lymphoblastoid Cell Lines
Identifying Genetic Modulators of Statin Response Using Subject-Derived Lymphoblastoid Cell Lines Open
Although statins (3-hydroxy-3-methylglutaryl-CoA reductase inhibitors) have proven effective in reducing plasma low-density lipoprotein levels and risk of cardiovascular disease, their lipid lowering efficacy is highly variable among indiv…
View article: The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals Open
To dissect the genetic architecture of blood pressure and assess effects on target-organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry and genotypes from an additional 140…
View article: Additional file 9 of Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines
Additional file 9 of Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines Open
Additional file 9: Table S9. Lead eQTL for average of endogenous and statin-treated LCL gene expression levels from meta-analysis with p<0.00001.
View article: Additional file 7 of Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines
Additional file 7 of Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines Open
Additional file 7: Table S7. Lead European ancestry eQTL for average of endogenous and statin-treated LCL gene expression levels.
View article: Additional file 6 of Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines
Additional file 6 of Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines Open
Additional file 6: Table S6. Lead statin-treated LCL eQTLs per gene from meta-analysis with p
View article: Additional file 4 of Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines
Additional file 4 of Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines Open
Additional file 4: Table S4. Lead statin-treated eQTLs per gene in LCLs from European ancestry subset.
View article: Additional file 5 of Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines
Additional file 5 of Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines Open
Additional file 5: Table S5. Lead statin-treated eQTLs per gene in LCLs from African American ancestry subset.
View article: Additional file 8 of Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines
Additional file 8 of Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines Open
Additional file 8: Table S8. Lead African American ancestry eQTL for average of endogenous and statin-treated LCL gene expression levels.
View article: Additional file 1 of Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines
Additional file 1 of Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines Open
Additional file 1: Table S1. Lead endogenous eQTLs per gene in LCLs from European ancestry subset.
View article: Additional file 10 of Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines
Additional file 10 of Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines Open
Additional file 10: Table S10. eQTL relationships in public datasets of our deQTL associations.