Fiona E. Watt
YOU?
Author Swipe
View article: Injury and local injection and the risk of foot/ankle osteoarthritis: a case–control study in retired UK male professional footballers
Injury and local injection and the risk of foot/ankle osteoarthritis: a case–control study in retired UK male professional footballers Open
Objective The objective of this study was to examine whether foot/ankle injury and injection contribute to the risk of foot/ankle OA in retired UK male professional footballers. Methods This was a case–control study among retired UK male f…
View article: Mechano-activated chondroprogenitors (MACs) drive intrinsic cartilage repair; a process that is arrested in osteoarthritis
Mechano-activated chondroprogenitors (MACs) drive intrinsic cartilage repair; a process that is arrested in osteoarthritis Open
Articular cartilage, an avascular, matrix-rich tissue, is thought to have limited repair, thereby contributing to osteoarthritis (OA), the common degenerative disease of joints. Cartilage regeneration does occur, however, in OA joints that…
View article: P076 Characterising flare and pain variability in individuals with symptomatic hand osteoarthritis - primary report from the Hand Osteoarthritis: investigating Pain (HOPE) Cohort
P076 Characterising flare and pain variability in individuals with symptomatic hand osteoarthritis - primary report from the Hand Osteoarthritis: investigating Pain (HOPE) Cohort Open
Background/Aims Despite being commonly reported by patients, the occurrence of episodic ‘flare’ and factors affecting it have not previously been studied in hand osteoarthritis. We investigated the associations between short-term fluctuati…
View article: E044 Long-term hand pain outcomes in hand osteoarthritis and their determinants in the Chingford 1000 Women Study
E044 Long-term hand pain outcomes in hand osteoarthritis and their determinants in the Chingford 1000 Women Study Open
Background/Aims Hand pain and hand osteoarthritis are common, particularly among peri-/post-menopausal women. Despite this, there are few studies on long-term outcomes and their determinants in this population. We examined associations bet…
View article: Current and future advances in practice: practical management of hand osteoarthritis
Current and future advances in practice: practical management of hand osteoarthritis Open
The high-quality management of hand osteoarthritis (OA) is crucial for improving the daily lives of people with the condition. The 2022 National Institute for Health and Care Excellence (NICE) guidelines for OA management emphasize educati…
View article: Development of methodology to support molecular endotype discovery from synovial fluid of individuals with knee osteoarthritis: The STEpUP OA consortium
Development of methodology to support molecular endotype discovery from synovial fluid of individuals with knee osteoarthritis: The STEpUP OA consortium Open
Objectives To develop a protocol for largescale analysis of synovial fluid proteins, for the identification of biological networks associated with subtypes of osteoarthritis. Methods S ynovial Fluid T o detect molecular E ndoty p es by U n…
View article: A mixed-methods approach exploring acceptability and feasibility of trials designed to test drugs targeting prevention of post-traumatic osteoarthritis after knee injury
A mixed-methods approach exploring acceptability and feasibility of trials designed to test drugs targeting prevention of post-traumatic osteoarthritis after knee injury Open
Aims To explore key stakeholder views around feasibility and acceptability of trials seeking to prevent post-traumatic osteoarthritis (PTOA) following knee injury, and provide guidance for next steps in PTOA trial design. Methods Healthcar…
View article: Association of serum biomarkers with radiographic knee osteoarthritis, knee pain and function in a young, male, trauma-exposed population – Findings from the ADVANCE study
Association of serum biomarkers with radiographic knee osteoarthritis, knee pain and function in a young, male, trauma-exposed population – Findings from the ADVANCE study Open
View article: Pain Reduction With Oral Methotrexate in Knee Osteoarthritis
Pain Reduction With Oral Methotrexate in Knee Osteoarthritis Open
Versus Arthritis.
View article: Deconvoluting synovial fluid molecular endotypes in knee osteoarthritis: primary results from the STEpUP OA Consortium
Deconvoluting synovial fluid molecular endotypes in knee osteoarthritis: primary results from the STEpUP OA Consortium Open
Background Osteoarthritis (OA) has a lifetime risk of over 40%, imposing a huge societal burden. Clinical variability suggests that it could be more than one disease. S ynovial fluid T o detect E ndoty p es by U nbiased P roteomics in OA (…
View article: The Effect of Acute Knee Injuries and Related Knee Surgery on Serum Levels of Pro- and Anti-inflammatory Lipid Mediators and Their Associations With Knee Symptoms
The Effect of Acute Knee Injuries and Related Knee Surgery on Serum Levels of Pro- and Anti-inflammatory Lipid Mediators and Their Associations With Knee Symptoms Open
Background: Despite an acute knee injury being a major risk factor for osteoarthritis, the factors that initiate and maintain this risk of longer-term knee symptoms are poorly understood. Bioactive lipids derived from omega-3 and -6 polyun…
View article: Toward designing human intervention studies to prevent osteoarthritis after knee injury: A report from an interdisciplinary OARSI 2023 workshop
Toward designing human intervention studies to prevent osteoarthritis after knee injury: A report from an interdisciplinary OARSI 2023 workshop Open
View article: Could sex-specific subtypes of hand osteoarthritis exist? A retrospective study in women presenting to secondary care
Could sex-specific subtypes of hand osteoarthritis exist? A retrospective study in women presenting to secondary care Open
Introduction Hand osteoarthritis is more common in women, and its risk increases around the time of the menopause. We set out to describe the timing between menopause and the onset of symptomatic hand osteoarthritis (OA), and associations …
View article: A Genome-Wide Association Study (GWAS) meta-analysis of post-traumatic osteoarthritis of the knee (GO-PTOA): Protocol for Analysis Plan
A Genome-Wide Association Study (GWAS) meta-analysis of post-traumatic osteoarthritis of the knee (GO-PTOA): Protocol for Analysis Plan Open
Post Traumatic Osteoarthritis (PTOA) of the knee is osteoarthritis (OA) occurring specifically after a significant acute injury to the joint. Approximately 50% of people with significant knee joint injuries, such as anterior cruciate ligam…
View article: Methodological development of molecular endotype discovery from synovial fluid of individuals with knee osteoarthritis: the STEpUP OA Consortium
Methodological development of molecular endotype discovery from synovial fluid of individuals with knee osteoarthritis: the STEpUP OA Consortium Open
Objectives To develop and validate a pipeline for quality controlled (QC) protein data for largescale analysis of synovial fluid (SF), using SomaLogic technology. Design Knee SF and associated clinical data were from partner cohorts. SF sa…
View article: Lifetime risk and genetic predisposition to post-traumatic OA of the knee in the UK Biobank
Lifetime risk and genetic predisposition to post-traumatic OA of the knee in the UK Biobank Open
Increasing age at injury and female sex appear to be associated with future development of PTOA in UKB, the risk of which was greatest in the 5 years after injury. Further international efforts towards a better-powered meta-analysis will d…
View article: Is it Autumn for colchicine and osteoarthritis?
Is it Autumn for colchicine and osteoarthritis? Open
View article: The influence of sex hormones on musculoskeletal pain and osteoarthritis
The influence of sex hormones on musculoskeletal pain and osteoarthritis Open
View article: Artificial intelligence in osteoarthritis: repair by knee joint distraction shows association of pain, radiographic and immunological outcomes
Artificial intelligence in osteoarthritis: repair by knee joint distraction shows association of pain, radiographic and immunological outcomes Open
Objectives Knee joint distraction (KJD) has been associated with clinical and structural improvement and SF marker changes. The current objective was to analyse radiographic changes after KJD using an automatic artificial intelligence-base…
View article: Hormone replacement therapy (conjugated oestrogens plus bazedoxifene) for post-menopausal women with symptomatic hand osteoarthritis: primary report from the HOPE-e randomised, placebo-controlled, feasibility study
Hormone replacement therapy (conjugated oestrogens plus bazedoxifene) for post-menopausal women with symptomatic hand osteoarthritis: primary report from the HOPE-e randomised, placebo-controlled, feasibility study Open
View article: Harmonising knee pain patient-reported outcomes: a systematic literature review and meta-analysis of Patient Acceptable Symptom State (PASS) and individual participant data (IPD)
Harmonising knee pain patient-reported outcomes: a systematic literature review and meta-analysis of Patient Acceptable Symptom State (PASS) and individual participant data (IPD) Open
Different standardised PROMs give similar PASS thresholds in group data. PASS thresholds may be affected more by patient and treatment characteristics than between PROMs. However, different PROMs give divergent scores within individuals, p…
View article: Research priorities to reduce the impact of musculoskeletal disorders: a priority setting exercise with the child health and nutrition research initiative method
Research priorities to reduce the impact of musculoskeletal disorders: a priority setting exercise with the child health and nutrition research initiative method Open
View article: P100 Research priorities to reduce the impact of musculoskeletal disorders
P100 Research priorities to reduce the impact of musculoskeletal disorders Open
Background/Aims Involving research users in setting priorities for research is essential to ensure research outcomes are patient-centred and to maximise research value and impact. In 2019, Versus Arthritis convened a Musculoskeletal Disord…
View article: CAN CONTINUOUS KNEE PAIN OUTCOME MEASURES BE HARMONISED?
CAN CONTINUOUS KNEE PAIN OUTCOME MEASURES BE HARMONISED? Open
View article: JOINT REPAIR EVALUATED AUTOMATICALLY ON RADIOGRAPHS IS ASSOCIATED WITH PAIN AND SYNOVIAL FLUID MARKER CHANGES AFTER KNEE JOINT DISTRACTION TREATMENT
JOINT REPAIR EVALUATED AUTOMATICALLY ON RADIOGRAPHS IS ASSOCIATED WITH PAIN AND SYNOVIAL FLUID MARKER CHANGES AFTER KNEE JOINT DISTRACTION TREATMENT Open
Knee joint distraction (KJD) has been associated with clinical and structural improvement and synovial fluid (SF) marker changes. However, structural changes have not yet been shown satisfactorily in regular care, since radiographic acquis…
View article: Versus Arthritis Musculoskeletal Disorders Research Advisory Group Priority Setting Exercise Protocol
Versus Arthritis Musculoskeletal Disorders Research Advisory Group Priority Setting Exercise Protocol Open
Involving research users in setting priorities for musculoskeletal research is essential to raise awareness of the unmet needs for MSK research, to ensure research outcomes are patient-centred and relevant, have a high likelihood of result…
View article: Variants in<i>ALDH1A2</i>reveal an anti-inflammatory role for retinoic acid and a new class of disease-modifying drugs in osteoarthritis
Variants in<i>ALDH1A2</i>reveal an anti-inflammatory role for retinoic acid and a new class of disease-modifying drugs in osteoarthritis Open
Over 40% of individuals will develop osteoarthritis (OA) during their lifetime, yet there are currently no licensed disease modifying treatments for this disabling condition. Common polymorphic variants in ALDH1A2 , that encodes the key en…
View article: Cartilage Repair Activity during Joint-Preserving Treatment May Be Accompanied by Osteophyte Formation
Cartilage Repair Activity during Joint-Preserving Treatment May Be Accompanied by Osteophyte Formation Open
Knee joint distraction (KJD) treatment has shown cartilage repair and clinical improvement in patients with osteoarthritis, as has high tibial osteotomy (HTO). Following KJD, TGFβ-1 and IL-6 were increased in synovial fluid (SF), factors r…
View article: Hand Osteoarthritis: investigating Pain Effects of estrogen-containing therapy (HOPE-e): a protocol for a feasibility randomised placebo-controlled trial
Hand Osteoarthritis: investigating Pain Effects of estrogen-containing therapy (HOPE-e): a protocol for a feasibility randomised placebo-controlled trial Open
View article: Clinical and molecular associations with outcomes at 2 years after acute knee injury: a longitudinal study in the Knee Injury Cohort at the Kennedy (KICK)
Clinical and molecular associations with outcomes at 2 years after acute knee injury: a longitudinal study in the Knee Injury Cohort at the Kennedy (KICK) Open