Elizaveta A. Urusova
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View article: [18F]R91150: Improved radiosynthesis and in vivo evaluation as imaging probe for 5-HT2A receptors
[18F]R91150: Improved radiosynthesis and in vivo evaluation as imaging probe for 5-HT2A receptors Open
Serotonergic 5-HT2A receptors in the cortex and other forebrain structures have been linked to cognitive, emotional and memory processes. In addition, dysfunction or altered expression of these receptors is associated with neuro…
View article: Radiosynthesis and Preclinical Evaluation of <i>m</i>-[<sup>18</sup>F]FET and [<sup>18</sup>F]FET-OMe as Novel [<sup>18</sup>F]FET Analogs for Brain Tumor Imaging
Radiosynthesis and Preclinical Evaluation of <i>m</i>-[<sup>18</sup>F]FET and [<sup>18</sup>F]FET-OMe as Novel [<sup>18</sup>F]FET Analogs for Brain Tumor Imaging Open
O-([18F]Fluoroethyl)-l-tyrosine ([18F]FET) is actively transported into the brain and cancer cells by LAT1 and possibly other amino acid transporters, which enables brain tumor imaging by positron emission tomo…
View article: CCDC 2205488: Experimental Crystal Structure Determination
CCDC 2205488: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: 7-[<sup>18</sup>F]Fluoro-8-azaisatoic Anhydrides: Versatile Prosthetic Groups for the Preparation of PET Tracers
7-[<sup>18</sup>F]Fluoro-8-azaisatoic Anhydrides: Versatile Prosthetic Groups for the Preparation of PET Tracers Open
18F-Fluorination of sensitive molecules is often challenging, but can be accomplished under suitably mild conditions using radiofluorinated prosthetic groups (PGs). Herein, 1-alkylamino-7-[18F]fluoro-8-azaisatoic anhy…
View article: CCDC 2202867: Experimental Crystal Structure Determination
CCDC 2202867: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2202868: Experimental Crystal Structure Determination
CCDC 2202868: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Next Generation Copper Mediators for the Efficient Production of <sup>18</sup>F‐Labeled Aromatics
Next Generation Copper Mediators for the Efficient Production of <sup>18</sup>F‐Labeled Aromatics Open
Cu‐mediated radiofluorination is a versatile tool for the preparation of 18 F‐labeled (hetero)aromatics. In this work, we systematically evaluated a series of complexes and identified several generally applicable mediators for highly effic…
View article: Rapid <sup>18</sup>F-labeling <i>via</i> Pd-catalyzed <i>S</i>-arylation in aqueous medium
Rapid <sup>18</sup>F-labeling <i>via</i> Pd-catalyzed <i>S</i>-arylation in aqueous medium Open
Rapid Pd-catalyzed S-arylation with easily accessible 2-[18F]fluoro-5-iodopyridine enables facile preparation of radiolabeled peptides and proteins.
View article: Alcohol-Supported Cu-Mediated 18F-Fluorination of Iodonium Salts under “Minimalist” Conditions
Alcohol-Supported Cu-Mediated 18F-Fluorination of Iodonium Salts under “Minimalist” Conditions Open
In the era of personalized precision medicine, positron emission tomography (PET) and related hybrid methods like PET/CT and PET/MRI gain recognition as indispensable tools of clinical diagnostics. A broader implementation of these imaging…
View article: Linked PDF of Table of Contents
Linked PDF of Table of Contents Open
Cleavage of Catechol Monoalkyl Ethers by Aluminum Triiodide-Dimethyl Sulfoxide HO RO AlI 3 (1.1 equiv) DMSO (1.1-2.5 equiv) MeCN, 80 °C, 18 h 30 substrates 34-100% yields
View article: Discovery of <sup>18</sup>F-JK-PSMA-7, a PET Probe for the Detection of Small PSMA-Positive Lesions
Discovery of <sup>18</sup>F-JK-PSMA-7, a PET Probe for the Detection of Small PSMA-Positive Lesions Open
Prostate-specific membrane antigen (PSMA), expressed by most prostate carcinomas (PCa), is a promising target for PCa imaging. The application of PSMA-specific 18F-labeled PET probes such as 18F-DCFPyL and 18
View article: A Practical One‐Pot Synthesis of Positron Emission Tomography (PET) Tracers via Nickel‐Mediated Radiofluorination
A Practical One‐Pot Synthesis of Positron Emission Tomography (PET) Tracers via Nickel‐Mediated Radiofluorination Open
Invited for this months cover picture is the group of Professor Bernd Neumaier at the Institute of Radiochemistry and Experimental Molecular Imaging at the University Clinic of Cologne. The cover picture shows the differences in brain meta…
View article: Cover Picture: A Practical One‐Pot Synthesis of Positron Emission Tomography (PET) Tracers via Nickel‐Mediated Radiofluorination (ChemistryOpen 4/2015)
Cover Picture: A Practical One‐Pot Synthesis of Positron Emission Tomography (PET) Tracers via Nickel‐Mediated Radiofluorination (ChemistryOpen 4/2015) Open
The cover picture shows the differences in brain metabolism of a healthy young and a healthy old subject, as well as a patient suffering from Parkinsons disease (left to right) uncovered by 6-[18F]FDOPA-positron emission tomography (PET). …
View article: A Practical One‐Pot Synthesis of Positron Emission Tomography (PET) Tracers via Nickel‐Mediated Radiofluorination
A Practical One‐Pot Synthesis of Positron Emission Tomography (PET) Tracers via Nickel‐Mediated Radiofluorination Open
Recently a novel method for the preparation of 18 F‐labeled arenes via oxidative [ 18 F]fluorination of easily accessible and sufficiently stable nickel complexes with [ 18 F]fluoride under exceptionally mild reaction conditions was publis…