Elke Schwier
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View article: Impact of glucocorticoid receptor polymorphism rs6198 on sepsis survival in a prospective multicenter cohort
Impact of glucocorticoid receptor polymorphism rs6198 on sepsis survival in a prospective multicenter cohort Open
The glucocorticoid receptor (GR), particularly its isoforms GRα and GRβ, plays a crucial role in modulating inflammatory responses. The rs6198 single nucleotide polymorphism (SNP) in the NR3C1 gene, which encodes GR, has been associated wi…
View article: High expression of L-GILZ transcript variant 1 (GILZ TV 1) is associated with increased 30-day sepsis mortality, and a high expression ratio possibly contraindicates hydrocortisone administration
High expression of L-GILZ transcript variant 1 (GILZ TV 1) is associated with increased 30-day sepsis mortality, and a high expression ratio possibly contraindicates hydrocortisone administration Open
Background Sepsis presents a challenge due to its complex immune responses, where balance between inflammation and anti-inflammation is critical for survival. Glucocorticoid-induced leucine zipper (GILZ) is key protein in achieving this ba…
View article: Isoflurane, like sepsis, decreases CYP1A2 liver enzyme activity in intensive care patients: a clinical study and network model
Isoflurane, like sepsis, decreases CYP1A2 liver enzyme activity in intensive care patients: a clinical study and network model Open
Purpose Liver function of intensive care patients is routinely monitored by static blood pathology. For specific indications, liver specific cytochrome activity may be measured by the commercially available maximum liver function capacity …
View article: The Association between the rs3747406 Polymorphism in the Glucocorticoid-Induced Leucine Zipper Gene and Sepsis Survivals Depends on the SOFA Score
The Association between the rs3747406 Polymorphism in the Glucocorticoid-Induced Leucine Zipper Gene and Sepsis Survivals Depends on the SOFA Score Open
The variability in mortality in sepsis could be a consequence of genetic variability. The glucocorticoid system and the intermediate TSC22D3 gene product—glucocorticoid-induced leucine zipper—are clinically relevant in sepsis, which is why…
View article: Protein Interaction Assessing Mitochondrial Biogenesis as a Next Generation Biomarker in Sepsis
Protein Interaction Assessing Mitochondrial Biogenesis as a Next Generation Biomarker in Sepsis Open
View article: The Aquaporin 3 Polymorphism (rs17553719) Is Associated with Sepsis Survival and Correlated with IL-33 Secretion
The Aquaporin 3 Polymorphism (rs17553719) Is Associated with Sepsis Survival and Correlated with IL-33 Secretion Open
Sepsis is a common life-threatening disease caused by dysregulated immune response and metabolic acidosis which lead to organ failure. An abnormal expression of aquaporins plays an important role in organ failure. Additionally, genetic var…
View article: AQP3 and AQP9—Contrary Players in Sepsis?
AQP3 and AQP9—Contrary Players in Sepsis? Open
Sepsis involves an immunological systemic response to a microbial pathogenic insult, leading to a cascade of interconnected biochemical, cellular, and organ–organ interaction networks. Potential drug targets can depict aquaporins, as they …
View article: Left-sided superior vena cava
Left-sided superior vena cava Open
View article: Immunomodulation by Hemoadsorption—Changes in Hepatic Biotransformation Capacity in Sepsis and Septic Shock: A Prospective Study
Immunomodulation by Hemoadsorption—Changes in Hepatic Biotransformation Capacity in Sepsis and Septic Shock: A Prospective Study Open
Background: Sepsis is often associated with liver dysfunction, which is an indicator of poor outcomes. Specific diagnostic tools that detect hepatic dysfunction in its early stages are scarce. So far, the immune modulatory effects of hemoa…
View article: Case report: Early detection of mesenteric ischemia by intravital microscopy in a patient with septic shock
Case report: Early detection of mesenteric ischemia by intravital microscopy in a patient with septic shock Open
Gut ischemia is a frequent but underdiagnosed complication, especially in critically ill intensive care patients, and represents a special diagnostic challenge that can only be solved in an interdisciplinary manner. We report a case of a 5…
View article: The impact of the COVID-19 pandemic on non-COVID induced sepsis survival
The impact of the COVID-19 pandemic on non-COVID induced sepsis survival Open
View article: Therapeutic Modulation of the Host Defense by Hemoadsorption with CytoSorb®—Basics, Indications and Perspectives—A Scoping Review
Therapeutic Modulation of the Host Defense by Hemoadsorption with CytoSorb®—Basics, Indications and Perspectives—A Scoping Review Open
The “normal” immune response to an insult triggers a highly regulated response determined by the interaction of various immunocompetent cells with pro- and anti-inflammatory cytokines. Under pathologic conditions, the massive elevation of …
View article: Profound decrease of liver maximum function capacity test of isoflurane sedated patients: A report of three cases
Profound decrease of liver maximum function capacity test of isoflurane sedated patients: A report of three cases Open
LiMAx 13C‐methacetin breath test results should be interpreted with caution in patients sedated with isoflurane.
View article: Does adjunctive hemoadsorption with CytoSorb affect survival of COVID-19 patients on ECMO? A critical statement
Does adjunctive hemoadsorption with CytoSorb affect survival of COVID-19 patients on ECMO? A critical statement Open
View article: Hemoadsorption with CytoSorb® and the early course of linezolid plasma concentration during septic shock
Hemoadsorption with CytoSorb® and the early course of linezolid plasma concentration during septic shock Open
View article: Pericarditis Caused by Enterococcus faecium with Acute Liver Failure Treated by a Multifaceted Approach including Antimicrobials and Hemoadsorption
Pericarditis Caused by Enterococcus faecium with Acute Liver Failure Treated by a Multifaceted Approach including Antimicrobials and Hemoadsorption Open
Background. Sepsis and septic shock are still life-threatening diseases with a high mortality rate. We report a complex case of peritonitis with pericarditis and acute liver failure caused by septic shock. Potentially hepatotoxic antibioti…
View article: Pericarditis caused by Enterococcus faecium with acute liver failure treated by a multifaceted approach including antimicrobials and hemoadsorption
Pericarditis caused by Enterococcus faecium with acute liver failure treated by a multifaceted approach including antimicrobials and hemoadsorption Open
Background Sepsis and septic shock are still life-threatening diseases with a high mortality rate. We report a complex case of peritonitis with pericarditis and acute liver failure caused by septic shock. Potentially hepato-toxic antibioti…
View article: Profound Decrease of Liver Maximum Function Capacity Test of Isoflurane Sedated Patients: A Report of Three Cases
Profound Decrease of Liver Maximum Function Capacity Test of Isoflurane Sedated Patients: A Report of Three Cases Open
Background: Recently, inhaled sedation and liver function capacity measurement using 13 C-methacetin breath test (LiMAx) have become an integral part of intensive care. The aim of this report is to present the results of LiMAx-testing duri…
View article: High-dose CytoSorb hemoadsorption is associated with improved survival in patients with septic shock: A retrospective cohort study
High-dose CytoSorb hemoadsorption is associated with improved survival in patients with septic shock: A retrospective cohort study Open
Background: Septic shock and SIRS are life-threatening diseases with persistent high mortality. Hemoadsorption with CytoSorb ® offers a possible therapeutic approach, but the optimal timing, dosing and indications are still unclear. Method…
View article: Dosing of Antimycotic Treatment in Sepsis–Induced Liver Dysfunction by Functional Liver Testing with LiMAx®
Dosing of Antimycotic Treatment in Sepsis–Induced Liver Dysfunction by Functional Liver Testing with LiMAx® Open
Background . Sepsis-treatment is one of the major challenges in our time. Especially fungal infections play an important role in patient’s morbidity and mortality. In patients with septic shock, liver function is often significantly impair…