Explanipedia

Adverse functions of neutrophils are regulated by neutrophilic angiotensin-converting enzyme in immune complex-mediated crescentic glomerulonephritis Open

Suguru Saito, Satoshi Kumakura, Zakir Khan, Ellen A. Bernstein, S. Ananth Karumanchi , et al. · 2025

We recently reported that NeuACE mice that overexpress angiotensin-converting enzyme (ACE), specifically in neutrophils, alleviate glomerular injury in immune complex-mediated crescentic glomerulonephritis by the complement C3b-complement …

Peroxisome proliferator-activated receptor alpha is an essential factor in enhanced macrophage immune function induced by angiotensin-converting enzyme Open

Suguru Saito, Duo‐Yao Cao, Ellen A. Bernstein, Tomohiro Shibata, Anthony E. Jones , et al. · 2025

Testicular ACE regulates sperm metabolism and fertilization through the transcription factor PPARγ Open

Tomohiro Shibata, Shabir Ahmad Bhat, Duo‐Yao Cao, Suguru Saito, Ellen A. Bernstein , et al. · 2023

Myeloid cell ACE shapes cellular metabolism and function in PCSK-9 induced atherosclerosis Open

Duo‐Yao Cao, Suguru Saito, LiMin Xu, Wei Fan, Xiaomo Li , et al. · 2023

The pathogenesis of atherosclerosis is defined by impaired lipid handling by macrophages which increases intracellular lipid accumulation. This dysregulation of macrophages triggers the accumulation of apoptotic cells and chronic inflammat…

Macrophage angiotensin-converting enzyme reduces atherosclerosis by increasing peroxisome proliferator-activated receptor α and fundamentally changing lipid metabolism Open

Duo‐Yao Cao, Zakir Khan, Xiaomo Li, Suguru Saito, Ellen A. Bernstein , et al. · 2023

Aims The metabolic failure of macrophages to adequately process lipid is central to the aetiology of atherosclerosis. Here, we examine the role of macrophage angiotensin-converting enzyme (ACE) in a mouse model of PCSK9-induced atheroscler…

miR766-3p and miR124-3p Dictate Drug Resistance and Clinical Outcome in HNSCC Open

Tomohiro Shibata, Duo‐Yao Cao, Mandar Patgaonkar, Faizan Ahmed, Shabir Ahmad Bhat , et al. · 2022

Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive disease with poor prognosis, which is mainly due to drug resistance. The biology determining the response to chemo-radiotherapy in HNSCC is poorly understood. Using clini…

Overexpressed angiotensin-converting enzyme in neutrophils suppresses glomerular damage in crescentic glomerulonephritis Open

Suguru Saito, Narihito Tatsumoto, Duo‐Yao Cao, Nobuyuki Nosaka, Hiroshi Nishi , et al. · 2022

We studied immune complex (IC)-mediated crescentic glomerulonephritis in NeuACE mice that overexpress ACE only in neutrophils. Such mice show no significant defects in humoral immunity but strongly resist nephrotoxic serum nephritis (less …

Tubular IL-1β Induces Salt Sensitivity in Diabetes by Activating Renal Macrophages Open

Luciana C. Veiras, Ellen A. Bernstein, Duo‐Yao Cao, Derick Okwan‐Duodu, Zakir Khan , et al. · 2022

Background: Chronic renal inflammation has been widely recognized as a major promoter of several forms of high blood pressure including salt-sensitive hypertension. In diabetes, IL (interleukin)-6 induces salt sensitivity through a dysregu…

The non-cardiovascular actions of ACE Open

Duo‐Yao Cao, Luciana C. Veiras, Faizan Ahmed, Tomohiro Shibata, Ellen A. Bernstein , et al. · 2022

An ACE inhibitor reduces bactericidal activity of human neutrophils in vitro and impairs mouse neutrophil activity in vivo Open

Duo‐Yao Cao, Jorge F. Giani, Luciana C. Veiras, Ellen A. Bernstein, Derick Okwan‐Duodu , et al. · 2021

ACE inhibitor treatment reduces human and mouse neutrophil function.

Novel roles of the renal angiotensin-converting enzyme Open

Jorge F. Giani, Luciana C. Veiras, Justin Z. Y. Shen, Ellen A. Bernstein, Duo‐Yao Cao , et al. · 2021

Renal Inflammation Induces Salt Sensitivity in Male db/db Mice through Dysregulation of ENaC Open

Luciana C. Veiras, Justin Z. Y. Shen, Ellen A. Bernstein, Giovanna C. Regis, Duo‐Yao Cao , et al. · 2021

Significance Statement Men with diabetes have higher incidence of renal disease and hypertension than premenopausal women with diabetes. A mouse model investigated the mechanisms that predispose to salt-sensitive hypertension during diabet…

Tumors exploit CXCR4 hi CD62L lo aged neutrophils to facilitate metastatic spread Open

Zhenzi Peng, Cuiwei Liu, Aaron Victor, Duo‐Yao Cao, Luciana C. Veiras , et al. · 2021

Granulocytes are key players in cancer metastasis. While tumor-induced de novo expansion of immunosuppressive myeloid-derived suppressor cells (MDSCs) is well-described, the fate and contribution of terminally differentiated mature …

Activation of AT2 receptors prevents diabetic complications in female db/db mice by NO‐mediated mechanisms Open

Fernando P. Dominici, Luciana C. Veiras, Justin Z. Y. Shen, Ellen A. Bernstein, D. Quiroga , et al. · 2020

Background and Purpose The AT 2 receptor plays a role in metabolism by opposing the actions triggered by the AT 1 receptors. Activation of AT 2 receptors has been shown to enhance insulin sensitivity in both normal and insulin resistance a…

Role of angiotensin-converting enzyme in myeloid cell immune responses Open

Duo‐Yao Cao, Suguru Saito, Luciana C. Veiras, Derick Okwan‐Duodu, Ellen A. Bernstein , et al. · 2020

ACE overexpression in myeloid cells increases oxidative metabolism and cellular ATP Open

Duo‐Yao Cao, Weston Spivia, Luciana C. Veiras, Zakir Khan, Zhenzi Peng , et al. · 2020

Angiotensin-converting enzyme (ACE) affects blood pressure. In addition, ACE overexpression in myeloid cells increases their immune function. Using MS and chemical analysis, we identified marked changes of intermediate metabolites in ACE-o…

Overexpression of ACE in Myeloid Cells Increases Immune Effectiveness and Leads to a New Way of Considering Inflammation in Acute and Chronic Diseases Open

Luciana C. Veiras, Duo‐Yao Cao, Suguru Saito, Zhenzi Peng, Ellen A. Bernstein , et al. · 2020

Index Open

Yakubu Princely Abudu, Endalkachew A. Alemu, Trevor Archer, B Baiocchi, Vytas A. Bankaitis , et al. · 2020

ACE overexpression in myeloid cells increases oxidative metabolism and cellular ATP Open

Duo‐Yao Cao, Weston Spivia, Luciana C. Veiras, Zakir Khan, Zhenzi Peng , et al. · 2019

Overexpression of myeloid angiotensin-converting enzyme (ACE) reduces atherosclerosis Open

Derick Okwan‐Duodu, Daiana Weiss, Zhenzi Peng, Luciana C. Veiras, Duo‐Yao Cao , et al. · 2019

ATP release drives heightened immune responses associated with hypertension Open

Tuantuan Zhao, Li Yu, Xiaoli Liu, Shudong Xia, Peng Shi , et al. · 2019

Hypertension promotes ATP release from erythrocytes, leading to a P2X7-dependent increase in T cell–mediated immune responses.

Index Open

Gosse J. Adema, Annette Aichem, Seiji Akimoto, Alaa Kassim, Saeedah Musaed Almutairi , et al. · 2019

Overexpression of the C-domain of angiotensin-converting enzyme reduces melanoma growth by stimulating M1 macrophage polarization Open

Zakir Khan, Duo‐Yao Cao, Jorge F. Giani, Ellen A. Bernstein, Luciana C. Veiras , et al. · 2019

Angiotensin-converting enzyme (ACE) can hydrolyze many peptides and plays a central role in controlling blood pressure. Moreover, ACE overexpression in monocytes and macrophages increases resistance of mice to tumor growth. ACE is composed…

The Absence of the ACE N-Domain Decreases Renal Inflammation and Facilitates Sodium Excretion during Diabetic Kidney Disease Open

Masahiro Eriguchi, Ellen A. Bernstein, Luciana C. Veiras, Zakir Khan, Duo‐Yao Cao , et al. · 2018

Background Recent evidence emphasizes the critical role of inflammation in the development of diabetic nephropathy. Angiotensin-converting enzyme (ACE) plays an active role in regulating the renal inflammatory response associated with diab…

Angiotensin‐converting enzyme inhibitor works as a scar formation inhibitor by down‐regulating Smad and TGF‐β‐activated kinase 1 (TAK1) pathways in mice Open

Wei‐Qiang Tan, Qing‐Qing Fang, Xiao Z. Shen, Jorge F. Giani, Tuantuan Zhao , et al. · 2018

Background and Purpose Angiotensin‐converting enzyme (ACE), an important part of the renin‐angiotensin system, is implicated in stimulating the fibrotic processes in the heart, lung, liver and kidney, while an ACE inhibitor (ACEI) promotes…

Angiotensin-converting enzyme in innate and adaptive immunity Open

Kenneth E. Bernstein, Zakir Khan, Jorge F. Giani, Duo‐Yao Cao, Ellen A. Bernstein , et al. · 2018

Renal tubular ACE-mediated tubular injury is the major contributor to microalbuminuria in early diabetic nephropathy Open

Masahiro Eriguchi, Mercury Lin, M Yamashita, Tuantuan Zhao, Zakir Khan , et al. · 2017

Diabetic nephropathy is a major cause of end-stage renal disease in developed countries. While angiotensin-converting enzyme (ACE) inhibitors are used to treat diabetic nephropathy, how intrarenal ACE contributes to diabetic renal injury i…

Angiotensin-converting enzyme defines matrikine-regulated inflammation and fibrosis Open

Philip O’Reilly, Qiang Ding, Samia Akthar, Guoqiang Cai, Kristopher R. Genschmer , et al. · 2017

The neutrophil chemoattractant proline-glycine-proline (PGP) is generated from collagen by matrix metalloproteinase-8/9 (MMP-8/9) and prolyl endopeptidase (PE), and it is concomitantly degraded by extracellular leukotriene A4 hydrolase (LT…

Angiotensin-converting enzyme enhances the oxidative response and bactericidal activity of neutrophils Open

Zakir Khan, Xiao Z. Shen, Ellen A. Bernstein, Jorge F. Giani, Masahiro Eriguchi , et al. · 2017

Key Points ACE plays an important physiological role in neutrophil antibacterial activity. ACE upregulation in mice neutrophils strongly enhances bactericidal activity via increased reduced NAD phosphate oxidase production of ROS.

Table of Contents Open

Christina Wyatt, Girish N. Nadkarni, Barbara Murphy, Michael G. Ross, Gunnar H. Heine , et al. · 2017

Ellen A. Bernstein YOU? Author Swipe