Ellen Buckley
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View article: Cocreating the Visualization of Digital Mobility Outcomes: Delphi-Type Process With Patients
Cocreating the Visualization of Digital Mobility Outcomes: Delphi-Type Process With Patients Open
Background Recent technological advances in wearable devices offer new potential for measuring mobility in real-world contexts. Mobilise-D has validated digital mobility outcomes to provide novel outcomes and end points in clinical researc…
View article: Cocreating the Visualization of Digital Mobility Outcomes: Delphi-Type Process With Patients (Preprint)
Cocreating the Visualization of Digital Mobility Outcomes: Delphi-Type Process With Patients (Preprint) Open
BACKGROUND Recent technological advances in wearable devices offer new potential for measuring mobility in real-world contexts. Mobilise-D has validated digital mobility outcomes to provide novel outcomes and end points in clinical researc…
Mobilise-D insights to estimate real-world walking speed in multiple conditions with a wearable device Open
This study aimed to validate a wearable device’s walking speed estimation pipeline, considering complexity, speed, and walking bout duration. The goal was to provide recommendations on the use of wearable devices for real-world mobility an…
View article: Ecological validity of a deep learning algorithm to detect gait events from real-life walking bouts in mobility-limiting diseases
Ecological validity of a deep learning algorithm to detect gait events from real-life walking bouts in mobility-limiting diseases Open
Introduction The clinical assessment of mobility, and walking specifically, is still mainly based on functional tests that lack ecological validity. Thanks to inertial measurement units (IMUs), gait analysis is shifting to unsupervised mon…
View article: Mobilizing Patient and Public Involvement in the Development of Real-World Digital Technology Solutions: Tutorial
Mobilizing Patient and Public Involvement in the Development of Real-World Digital Technology Solutions: Tutorial Open
Although the value of patient and public involvement and engagement (PPIE) activities in the development of new interventions and tools is well known, little guidance exists on how to perform these activities in a meaningful way. This is p…
View article: Laboratory and free-living gait performance in adults with COPD and healthy controls
Laboratory and free-living gait performance in adults with COPD and healthy controls Open
Background Gait characteristics are important risk factors for falls, hospitalisations and mortality in older adults, but the impact of COPD on gait performance remains unclear. We aimed to identify differences in gait characteristics betw…
View article: A Single-Sensor Approach to Quantify Gait in Patients with Hereditary Spastic Paraplegia
A Single-Sensor Approach to Quantify Gait in Patients with Hereditary Spastic Paraplegia Open
Hereditary spastic paraplegia (HSP) is characterised by progressive lower-limb spasticity and weakness resulting in ambulation difficulties. During clinical practice, walking is observed and/or assessed by timed 10-m walk tests; time, feas…
View article: Estimating real-world walking speed from a single wearable device: analytical pipeline, results and lessons learnt from the Mobilise-D technical validation study
Estimating real-world walking speed from a single wearable device: analytical pipeline, results and lessons learnt from the Mobilise-D technical validation study Open
Background: Estimation of walking speed from wearable devices requires combining a set of algorithms in a single analytical pipeline. The aim of this study was to validate a pipeline for walking speed estimation and assess its performance …
View article: A Double‐Blind, Randomized, Placebo‐Controlled Trial of Ursodeoxycholic Acid (<scp>UDCA)</scp> in Parkinson's Disease
A Double‐Blind, Randomized, Placebo‐Controlled Trial of Ursodeoxycholic Acid (<span>UDCA)</span> in Parkinson's Disease Open
Background Rescue of mitochondrial function is a promising neuroprotective strategy for Parkinson's disease (PD). Ursodeoxycholic acid (UDCA) has shown considerable promise as a mitochondrial rescue agent across a range of preclinical in v…
View article: A multi-sensor wearable system for the assessment of diseased gait in real-world conditions
A multi-sensor wearable system for the assessment of diseased gait in real-world conditions Open
Introduction: Accurately assessing people’s gait, especially in real-world conditions and in case of impaired mobility, is still a challenge due to intrinsic and extrinsic factors resulting in gait complexity. To improve the estimation of …
View article: Data sample INDIP Validation Paper
Data sample INDIP Validation Paper Open
Standardized data from Mobilise-D HYA dataset (one participant, data from both laboratory and 2.5 hours) and Mobilise-D technical validation dataset (one subject for each cohort - HOA, PD, MS, COPD, CHF, PFF; data from 2.5 hours) are provi…
View article: Data sample INDIP Validation Paper
Data sample INDIP Validation Paper Open
Standardized data from Mobilise-D HYA dataset (one participant, data from both laboratory and 2.5 hours) and Mobilise-D technical validation dataset (one subject for each cohort - HOA, PD, MS, COPD, CHF, PFF; data from 2.5 hours) are provi…
Comment on egusphere-2023-31 Open
Abstract. The CryoSat-2 radar altimeter and ICESat-2 laser altimeter can provide complimentary measurements of the freeboard and thickness of Arctic sea ice. However, both sensors face significant challenges for accurately measuring the ic…
View article: Assessing real-world gait with digital technology? Validation, insights and recommendations from the Mobilise-D consortium
Assessing real-world gait with digital technology? Validation, insights and recommendations from the Mobilise-D consortium Open
Dataset includes 2.5 hours real-world data, for one participant from each of the technical validation study cohorts: ongestive heart failure (CHF), chronic obstructive pulmonary disease (COPD), healthy adult (HA), multiple sclerosis (MS), …
View article: Assessing real-world gait with digital technology? Validation, insights and recommendations from the Mobilise-D consortium
Assessing real-world gait with digital technology? Validation, insights and recommendations from the Mobilise-D consortium Open
Dataset includes 2.5 hours real-world data, for one participant from each of the technical validation study cohorts: ongestive heart failure (CHF), chronic obstructive pulmonary disease (COPD), healthy adult (HA), multiple sclerosis (MS), …
View article: A multi-sensor wearable system for gait assessment in real-world conditions: performance in individuals with impaired mobility
A multi-sensor wearable system for gait assessment in real-world conditions: performance in individuals with impaired mobility Open
Accurately assessing people’s gait, especially in real-world conditions and in case of impaired mobility, is still a challenge due to intrinsic and extrinsic factors resulting in gait complexity. To improve the estimation of gait-related d…
View article: Acceptability of wearable devices for measuring mobility remotely: Observations from the Mobilise-D technical validation study
Acceptability of wearable devices for measuring mobility remotely: Observations from the Mobilise-D technical validation study Open
Background This study aimed to explore the acceptability of a wearable device for remotely measuring mobility in the Mobilise-D technical validation study (TVS), and to explore the acceptability of using digital tools to monitor health. Me…
Design and validation of a multi-task, multi-context protocol for real-world gait simulation Open
Background Measuring mobility in daily life entails dealing with confounding factors arising from multiple sources, including pathological characteristics, patient specific walking strategies, environment/context, and purpose of the task. …
View article: Mobilizing Patient and Public Involvement in the Development of Real-World Digital Technology Solutions: Tutorial (Preprint)
Mobilizing Patient and Public Involvement in the Development of Real-World Digital Technology Solutions: Tutorial (Preprint) Open
UNSTRUCTURED Although the value of patient and public involvement and engagement (PPIE) activities in the development of new interventions and tools is well known, little guidance exists on how to perform these activities in a meaningful w…
View article: Connecting real-world digital mobility assessment to clinical outcomes for regulatory and clinical endorsement–the Mobilise-D study protocol
Connecting real-world digital mobility assessment to clinical outcomes for regulatory and clinical endorsement–the Mobilise-D study protocol Open
Background The development of optimal strategies to treat impaired mobility related to ageing and chronic disease requires better ways to detect and measure it. Digital health technology, including body worn sensors, has the potential to d…
View article: Assessing real-world gait with digital technology? Validation, insights and recommendations from the Mobilise-D consortium
Assessing real-world gait with digital technology? Validation, insights and recommendations from the Mobilise-D consortium Open
Background: Although digital mobility outcomes (DMOs) can be readily calculated from real-world data collected with wearable devices (WD) and ad-hoc algorithms, technical validation is still required. The aim of this paper is to comparativ…
Effect of Remote Ischemic Conditioning on Heart Rate Responses to Walking in People with Multiple Sclerosis Open
Background: Remote ischemic conditioning (RIC), exposure of body parts to brief periods of circulatory occlusion and reperfusion, has been shown to improve cardiovascular responses to exercise in healthy individuals but its effects in peop…
View article: Design and validation of a multi-task, multi-phase protocol for real-world gait simulation
Design and validation of a multi-task, multi-phase protocol for real-world gait simulation Open
Background: Measuring mobility in daily life entails dealing with confounding factors arising from multiple sources, including pathological characteristics, patient specific walking strategies, environment/context, and purpose of the task.…
View article: An Algorithm for Accurate Marker-Based Gait Event Detection in Healthy and Pathological Populations During Complex Motor Tasks
An Algorithm for Accurate Marker-Based Gait Event Detection in Healthy and Pathological Populations During Complex Motor Tasks Open
There is growing interest in the quantification of gait as part of complex motor tasks. This requires gait events (GEs) to be detected under conditions different from straight walking. This study aimed to propose and validate a new marker-…