Ellen C. Breen
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View article: Cigarette smoke exposure impairs early‐stage recovery from lengthening contraction‐induced muscle injury in male mice
Cigarette smoke exposure impairs early‐stage recovery from lengthening contraction‐induced muscle injury in male mice Open
The use of tobacco cigarettes produces locomotor muscle weakness and fatigue intolerance. Also, smokers and chronic obstructive pulmonary disease patients have a greater incidence of muscle injury and a deficient myogenic response. However…
View article: Nicotine inhalant via E‐cigarette facilitates sensorimotor function recovery by upregulating neuronal BDNF–TrkB signalling in traumatic brain injury
Nicotine inhalant via E‐cigarette facilitates sensorimotor function recovery by upregulating neuronal BDNF–TrkB signalling in traumatic brain injury Open
Background and Purpose Traumatic brain injury (TBI) causes lifelong physical and psychological dysfunction in affected individuals. The current study investigated the effects of chronic nicotine exposure via E‐cigarettes (E‐cig) (vaping) o…
View article: E-cigarette aerosol impairs male mouse skeletal muscle force development and prevents recovery from injury
E-cigarette aerosol impairs male mouse skeletal muscle force development and prevents recovery from injury Open
To date, there has been a lag between the rise in E-cigarette use and an understanding of the long-term health effects. Inhalation of E-cigarette aerosol delivers high doses of nicotine, raises systemic cytokine levels, and compromises car…
View article: IL‐33/ST2 receptor‐dependent signaling in the development of pulmonary hypertension in Sugen/hypoxia mice
IL‐33/ST2 receptor‐dependent signaling in the development of pulmonary hypertension in Sugen/hypoxia mice Open
Pulmonary arterial hypertension (PAH) is associated with significant morbidity and mortality. PAH is characterized by pulmonary artery remodeling, elevated right ventricular pressure (RVP) and, ultimately, cardiac failure. Pulmonary endoth…
View article: Table S1
Table S1 Open
Table S1. Echocardiogram and Pulse Wave Tissue Doppler Measurements.
View article: Table S1
Table S1 Open
Table S1. Echocardiogram and Pulse Wave Tissue Doppler Measurements.
View article: Role of IL-33 receptor (ST2) deletion in diaphragm contractile and mitochondrial function in the Sugen5416/hypoxia model of pulmonary hypertension
Role of IL-33 receptor (ST2) deletion in diaphragm contractile and mitochondrial function in the Sugen5416/hypoxia model of pulmonary hypertension Open
Pulmonary arterial hypertension (PAH) is a progressive disease of the pulmonary vasculature that leads to right ventricular failure. Skeletal muscle maladaptations limit physical activity and may contribute to disease progression. The role…
View article: Upregulation of Calcium Homeostasis Modulators in Contractile-To-Proliferative Phenotypical Transition of Pulmonary Arterial Smooth Muscle Cells
Upregulation of Calcium Homeostasis Modulators in Contractile-To-Proliferative Phenotypical Transition of Pulmonary Arterial Smooth Muscle Cells Open
Excessive pulmonary artery (PA) smooth muscle cell (PASMC) proliferation and migration are implicated in the development of pathogenic pulmonary vascular remodeling characterized by concentric arterial wall thickening and arteriole muscula…
View article: Hepatocyte HIF-1 and Intermittent Hypoxia Independently Impact Liver Fibrosis in Murine Nonalcoholic Fatty Liver Disease
Hepatocyte HIF-1 and Intermittent Hypoxia Independently Impact Liver Fibrosis in Murine Nonalcoholic Fatty Liver Disease Open
Obstructive sleep apnea is associated with insulin resistance, lipid dysregulation, and hepatic steatosis and fibrosis in nonalcoholic fatty liver disease (NAFLD). We have previously shown that hepatocyte HIF-1 (hypoxia-inducible factor-1)…
View article: Cigarettes Make You Weak: RANKL/RANK Link Changes in Muscle and Bone
Cigarettes Make You Weak: RANKL/RANK Link Changes in Muscle and Bone Open
View article: Enhanced O2-Dependent Mitochondrial Activation in Myofibers from CMP N-Glycolylneuraminic Acid Hydroxylase (Cmah) Gene Inactivated Mice
Enhanced O2-Dependent Mitochondrial Activation in Myofibers from CMP N-Glycolylneuraminic Acid Hydroxylase (Cmah) Gene Inactivated Mice Open
View article: Skeletal myofiber VEGF deficiency leads to mitochondrial, structural, and contractile alterations in mouse diaphragm
Skeletal myofiber VEGF deficiency leads to mitochondrial, structural, and contractile alterations in mouse diaphragm Open
Diaphragm dysfunction accompanies cardiopulmonary disease and impaired oxygen delivery. Vascular endothelial growth factor (VEGF) regulates oxygen delivery through angiogenesis, capillary maintenance, and contraction-induced perfusion. We …
View article: DCU Press: Vision to Reality
DCU Press: Vision to Reality Open
The past number of years has seen a growing trend in the establishment of University Presses. This growth in institutional publishing is a direct response to the changing scholarly communication landscape. Drivers include an increased awar…
View article: Cigarette Smoke Triggers IL-33–associated Inflammation in a Model of Late-Stage Chronic Obstructive Pulmonary Disease
Cigarette Smoke Triggers IL-33–associated Inflammation in a Model of Late-Stage Chronic Obstructive Pulmonary Disease Open
Chronic obstructive pulmonary disease (COPD) is a worldwide threat. Cigarette smoke (CS) exposure causes cardiopulmonary disease and COPD and increases the risk for pulmonary tumors. In addition to poor lung function, patients with COPD ar…
View article: Human-like Cmah inactivation in mice increases running endurance and decreases muscle fatigability: implications for human evolution
Human-like Cmah inactivation in mice increases running endurance and decreases muscle fatigability: implications for human evolution Open
Compared to other primates, humans are exceptional long-distance runners, a feature that emerged in genus Homo approximately 2 Ma and is classically attributed to anatomical and physiological adaptations such as an enlarged gluteus maximus…
View article: Cigarette smoke directly impairs skeletal muscle function through capillary regression and altered myofibre calcium kinetics in mice
Cigarette smoke directly impairs skeletal muscle function through capillary regression and altered myofibre calcium kinetics in mice Open
Key points Cigarette smoke components directly alter muscle fatigue resistance and intracellular muscle fibre Ca 2+ handling independent of a change in lung structure. Changes in muscle vascular structure are associated with a depletion of…
View article: Chronic inhalation of e-cigarette vapor containing nicotine disrupts airway barrier function and induces systemic inflammation and multiorgan fibrosis in mice
Chronic inhalation of e-cigarette vapor containing nicotine disrupts airway barrier function and induces systemic inflammation and multiorgan fibrosis in mice Open
Electronic (e)-cigarettes theoretically may be safer than conventional tobacco. However, our prior studies demonstrated direct adverse effects of e-cigarette vapor (EV) on airway cells, including decreased viability and function. We hypoth…
View article: Supplementary material from "Human-like Cmah inactivation in mice increases running endurance and decreases muscle fatigability: implications for human evolution"
Supplementary material from "Human-like Cmah inactivation in mice increases running endurance and decreases muscle fatigability: implications for human evolution" Open
Compared to other primates, humans are exceptional long-distance runners, a feature that emerged in genus Homo approximately 2 Ma and is classically attributed to anatomical and physiological adaptations such as an enlarged gluteus …
View article: Skeletal myofiber vascular endothelial growth factor is required for the exercise training‐induced increase in dentate gyrus neuronal precursor cells
Skeletal myofiber vascular endothelial growth factor is required for the exercise training‐induced increase in dentate gyrus neuronal precursor cells Open
Key points Peripheral vascular endothelial growth factor (VEGF) is necessary for exercise to stimulate hippocampal neurogenesis. Here we report that skeletal myofiber VEGF directly or indirectly regulates exercise‐signalled proliferation o…
View article: Effects of chronic inhalation of electronic cigarettes containing nicotine on glial glutamate transporters and α-7 nicotinic acetylcholine receptor in female CD-1 mice
Effects of chronic inhalation of electronic cigarettes containing nicotine on glial glutamate transporters and α-7 nicotinic acetylcholine receptor in female CD-1 mice Open
View article: Functional magnetic resonance imaging for <i>in vivo</i> quantification of pulmonary hypertension in the Sugen 5416/hypoxia mouse
Functional magnetic resonance imaging for <i>in vivo</i> quantification of pulmonary hypertension in the Sugen 5416/hypoxia mouse Open
New Findings What is the central question of this study? Non‐invasive, quantitative methods to assess right cardiac function in mice with pulmonary hypertension have not been demonstrated. What is the main finding and its importance? This …
View article: Skeletal myofiber VEGF regulates contraction-induced perfusion and exercise capacity but not muscle capillarity in adult mice
Skeletal myofiber VEGF regulates contraction-induced perfusion and exercise capacity but not muscle capillarity in adult mice Open
A single bout of exhaustive exercise signals expression of vascular endothelial growth factor (VEGF) in the exercising muscle. Previous studies have reported that mice with life-long deletion of skeletal myofiber VEGF have fewer capillarie…
View article: Skeletal myofiber VEGF is necessary for myogenic and contractile adaptations to functional overload of the plantaris in adult mice
Skeletal myofiber VEGF is necessary for myogenic and contractile adaptations to functional overload of the plantaris in adult mice Open
The ability to enhance muscle size and function is important for overall health. In this study, skeletal myofiber vascular endothelial growth factor (VEGF) was hypothesized to regulate hypertrophy, capillarity, and contractile function in …