Ellen E. E. Jarrett
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Surface phenotype of T cells producing growth of mucosal mast cells in normal rat bone marrow culture. Open
We have previously shown that lymphocytes from Nippostrongylus brasiliensis infected rats, when stimulated with antigen or concanavalin A (Con A) release factors which are comparable with murine IL-3. On addition of these factors to rat bo…
The development of IgE-suppressive immunocompetence in young animals: influence of exposure to antigen in the presence or absence of maternal immunity. Open
Previous studies recognized a prolonged suppression of egg-albumin (EA)-specific IgE responsiveness in the progeny of immunized female rats, and showed that an identical effect was produced by the administration of small amounts of specifi…
In vitro studies on mast cell proliferation in N. brasiliensis infection. Open
We have previously shown that mast cells with the morphological and biochemical properties of mucosal mast cells (MMC) proliferate and mature in rat bone marrow cultures stimulated with factors from antigen or mitogen-activated T lymphocyt…
Stimulation of mucosal mast cell growth in normal and nude rat bone marrow cultures. Open
Mast cells with the morphological and biochemical properties of mucosal mast cells (MMC) appear and proliferate to form the predominant cell type in rat bone marrow cultures stimulated with factors from antigen- or mitogen-activated lympho…
IgE suppression by maternal IgG. Open
Rats born of egg albumin immunized mothers have a diminished capacity to produce IgE antibody to egg albumin persisting for at least 13-14 weeks after birth. At the same time the primary IgG response to the antigen is usually enhanced. Pre…
Adjuvants in the induction and enhancement of rat IgE responses. Open
In Hooded Lister rats the primary IgE antibody response induced by immunization with antigen and adjuvant may be enhanced either specifically by a further dose of antigen (booster response) or non-specifically by infection with helminth pa…
Serum immunoglobulin levels in N. brasiliensis infection. Open
We have measured the levels of IgG1, IgG2a, IgG2c, IgA and IgM in the serum of normal rats, and at various times after infection or re-infection with Nippostrongylus brasiliensis, in order to compare these responses with previously measure…
Time course studies on rat IgE production in N. Brasiliensis infection. Open
We present here a study of the relationship in time between the elevation of total serum IgE, the parasite-specific IgE response, and the potentiated IgE response to unrelated antigen which occurs in rats following infection with the worm …
Rat IgE production. II. Primary and booster reaginic antibody responses following intradermal or oral immunization. Open
Primary and booster IgE antibody responses have been elicited in Hooded Lister rats by the intradermal injection or oral administration of very small quantities of egg albumin. Oral immunization was effected by giving antigen by stomach tu…
Hypersensitivity reactions in small intestine. I Thymus dependence of experimental 'partial villous atrophy'. Open
Rats infected with the intestinal nematode Nippostrongylus brasiliensis have crypt hyperplasia with villous atrophy in affected areas of the small intestine. In thymus-deprived (B) rats the course of infection is prolonged but, despite the…
Rat IgE production. I. Effect of dose of antigen on primary and secondary reaginic antibody responses. Open
The experiments described here form part of a series carried out to determine the conditions of antigen presentation which dispose to the production of IgE antibody in the rat. We have found that Hooded Lister rats in comparison with rats …
The significance of circulating IgE. Correlation of amount of circulating reaginic antibody with cutaneous sensitivity in the rat. Open
In order to determine the relationship between the level of circulating reaginic (IgE) antibody and degree of cutaneous hypersensitivity, rats producing different titres of reaginic antibody were assessed for skin test reactivity by means …
Potentiation of rat reaginic (IgE) antibody by helminth infection. Simultaneous potentiation of separate reagins. Open
Further evidence has been produced that rat reaginic antibody responses which have been programmed by the injection of antigen with Bordetella pertussis can be greatly potentiated by a subsequent infection with the helminth parasite Nippos…
Inhibition of allergic reactions due to competition for mast cell sensitization sites by two reagins. Open
The ability of unrelated or incidental reagin to interfere competitively with mast cell sensitization by specific reagin has been examined using an experimental system whereby rats are induced to produce high levels of reaginic (IgE) antib…
Diminished immunological responsiveness to helminth parasites. The effect of repeated reinfection of rats from an early age with Nippostrongylus brasiliensis. Open
An unusual form of immunological unresponsiveness peculiarly suited to the propagation of nematode parasites has been revealed by a study of the effect of repeated reinfection of rats from an early age with Nippostrongylus brasiliensis. In…