Ellen E. Quillen
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View article: DEEP PROTEOMIC PROFILING OF ACCELERATED KIDNEY AGING AND SENESCENCE BURDEN IN MACACA MULATTA
DEEP PROTEOMIC PROFILING OF ACCELERATED KIDNEY AGING AND SENESCENCE BURDEN IN MACACA MULATTA Open
Whole-body ionizing radiation (IR) is a stressor that causes damage to DNA, lipids, and proteins, and in the latent-phase, may lead to oxidative stress, inflammation, and cellular senescence. Slowly-reproducing tissues, including kidney, a…
View article: Comparative lifespan and healthspan of nonhuman primate species common to biomedical research
Comparative lifespan and healthspan of nonhuman primate species common to biomedical research Open
View article: Social genomics, cognition, and well‐being during the COVID‐19 pandemic
Social genomics, cognition, and well‐being during the COVID‐19 pandemic Open
INTRODUCTION Adverse psychosocial exposure is associated with increased pro‐inflammatory gene expression and reduced type‐1 interferon gene expression known as the conserved transcriptional response to adversity (CTRA). CTRA is not well‐st…
View article: Comparative lifespan and healthspan of nonhuman primate species common to biomedical research
Comparative lifespan and healthspan of nonhuman primate species common to biomedical research Open
There is a critical need to generate age- and sex-specific survival curves to characterize chronological aging consistently across nonhuman primates (NHP) used in biomedical research. Sex-specific Kaplan-Meier survival curves were computed…
View article: MULTIMORBIDITY PREDICTS REMAINING LIFESPAN IN NONHUMAN PRIMATE MODEL OF ACCELERATED AGING
MULTIMORBIDITY PREDICTS REMAINING LIFESPAN IN NONHUMAN PRIMATE MODEL OF ACCELERATED AGING Open
Multimorbidity is common among older adults and linked to shorter lifespans, but it is unclear how naturally-occurring multimorbidity impacts lifespan in non-human primate models of aging. We developed a clinical multimorbidity index based…
View article: Social genomics, cognition, and well-being during the COVID-19 pandemic
Social genomics, cognition, and well-being during the COVID-19 pandemic Open
INTRODUCTION Adverse psychosocial exposure is associated with increased proinflammatory gene expression and reduced type-1 interferon gene expression, a profile known as the conserved transcriptional response to adversity (CTRA). Little is…
View article: Resilience, aging, and response to radiation exposure (RARRE) in nonhuman primates: a resource review
Resilience, aging, and response to radiation exposure (RARRE) in nonhuman primates: a resource review Open
View article: Perceived Stress and Loneliness During the COVID‐19 Pandemic in a Cognitive Aging Cohort
Perceived Stress and Loneliness During the COVID‐19 Pandemic in a Cognitive Aging Cohort Open
Background The COVID‐19 pandemic has had disproportionate effects on the health and well‐being of older adults. Little is known about the effects of isolation and social distancing measures on the mental health of older adults with cogniti…
View article: PATTERNS OF MULTIMORBIDITY IN AGING, RADIATION-EXPOSED NON-HUMAN PRIMATES
PATTERNS OF MULTIMORBIDITY IN AGING, RADIATION-EXPOSED NON-HUMAN PRIMATES Open
Resilience to stressors is a major component of biological aging and may mediate the onset of multimorbidity in older adults. The Wake Forest Non-Human Primate Radiation Survivor Cohort (RSC) provides a novel opportunity to study aging and…
View article: A New Method of Bone Stromal Cell Characterization by Flow Cytometry
A New Method of Bone Stromal Cell Characterization by Flow Cytometry Open
The bone microenvironment cellular composition plays an essential role in bone health and is disrupted in bone pathologies, such as osteoporosis, osteoarthritis, and cancer. Flow cytometry protocols for hematopoietic stem cell lineages are…
View article: Integrated omics analysis reveals sirtuin signaling is central to hepatic response to a high fructose diet
Integrated omics analysis reveals sirtuin signaling is central to hepatic response to a high fructose diet Open
Background Dietary high fructose (HFr) is a known metabolic disruptor contributing to development of obesity and diabetes in Western societies. Initial molecular changes from exposure to HFr on liver metabolism may be essential to understa…
View article: Differentially Methylated Genes in Muscle Associated with Gait Speed in a Non-Human Primate Model of Aging
Differentially Methylated Genes in Muscle Associated with Gait Speed in a Non-Human Primate Model of Aging Open
Age-related changes in DNA methylation are potent regulators of gene expression and may in part explain the onset of disease and disability. Vervet monkeys are a well-described model of neurocognitive and physical aging. Like humans, gait …
View article: Circulating miRNAs associated with bone mineral density in healthy adult baboons
Circulating miRNAs associated with bone mineral density in healthy adult baboons Open
MicroRNAs (miRNAs) regulate gene expression post‐transcriptionally and circulate in the blood, making them attractive biomarkers of disease state for tissues like bone that are challenging to interrogate directly. Here, we report on five m…
View article: Heterozygosity of the major histocompatibility complex predicts later self-reported pubertal maturation in men
Heterozygosity of the major histocompatibility complex predicts later self-reported pubertal maturation in men Open
View article: Improving rigor and reproducibility in nonhuman primate research
Improving rigor and reproducibility in nonhuman primate research Open
Nonhuman primates (NHPs) are a critical component of translational/preclinical biomedical research due to the strong similarities between NHP and human physiology and disease pathology. In some cases, NHPs represent the most appropriate, o…
View article: Integrated Omics Analysis Reveals Sirtuin Signaling is Central to Hepatic Response to a High Fructose Diet
Integrated Omics Analysis Reveals Sirtuin Signaling is Central to Hepatic Response to a High Fructose Diet Open
Background Dietary high fructose (HFr) is a known metabolic disruptor contributing to development of obesity and diabetes in Western societies. Initial molecular changes from exposure to HFr on liver metabolism may be essential to understa…
View article: Circulating miRNAs associated with bone mineral density in healthy adult baboons
Circulating miRNAs associated with bone mineral density in healthy adult baboons Open
MicroRNAs (miRNAs) regulate gene expression post-transcriptionally and circulate in the blood, making them attractive biomarkers of disease state for tissues like bone that are challenging to interrogate directly. Here we report on five mi…
View article: Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction
Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction Open
Metabolic reprogramming between resistance and tolerance occurs within the immune system in response to sepsis. While metabolic tissues such as the liver are subjected to damage during sepsis, how their metabolic and energy reprogramming e…
View article: Author response: Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction
Author response: Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction Open
View article: Additional file 13 of Integrated omics analysis reveals sirtuin signaling is central to hepatic response to a high fructose diet
Additional file 13 of Integrated omics analysis reveals sirtuin signaling is central to hepatic response to a high fructose diet Open
Additional file 13. Gene & Protein Pathways: Enrichment analysis combining genes and proteins with p-value < 0.05.
View article: Additional file 5 of Integrated omics analysis reveals sirtuin signaling is central to hepatic response to a high fructose diet
Additional file 5 of Integrated omics analysis reveals sirtuin signaling is central to hepatic response to a high fructose diet Open
Additional file 5. Gene Networks: Enrichment analysis of genes with p-value < 0.05.
View article: Additional file 14 of Integrated omics analysis reveals sirtuin signaling is central to hepatic response to a high fructose diet
Additional file 14 of Integrated omics analysis reveals sirtuin signaling is central to hepatic response to a high fructose diet Open
Additional file 14. Gene & Protein Networks: Enrichment analysis combining genes and proteins with p-value < 0.05.
View article: Additional file 7 of Integrated omics analysis reveals sirtuin signaling is central to hepatic response to a high fructose diet
Additional file 7 of Integrated omics analysis reveals sirtuin signaling is central to hepatic response to a high fructose diet Open
Additional file 7. Protein Pathways: Enrichment analysis of proteins with p-value < 0.05.
View article: Additional file 10 of Integrated omics analysis reveals sirtuin signaling is central to hepatic response to a high fructose diet
Additional file 10 of Integrated omics analysis reveals sirtuin signaling is central to hepatic response to a high fructose diet Open
Additional file 10. Metabolite List: Metabolites passing quality filters with ratios and p-values for HFr versus CON.
View article: Additional file 19 of Integrated omics analysis reveals sirtuin signaling is central to hepatic response to a high fructose diet
Additional file 19 of Integrated omics analysis reveals sirtuin signaling is central to hepatic response to a high fructose diet Open
Additional file 19. Differentially Expressed Gene and Protein: List of GWAS hits of differentially expressed genes and proteins for HFr versus CON.
View article: Additional file 18 of Integrated omics analysis reveals sirtuin signaling is central to hepatic response to a high fructose diet
Additional file 18 of Integrated omics analysis reveals sirtuin signaling is central to hepatic response to a high fructose diet Open
Additional file 18. Gene-Protein with miRNA pairs: miRNA pairing with target genes and proteins either highly predicted or experimentally validated for differentially expressed miRNAs, genes and proteins for HFr versus CON (p-value < 0.05).
View article: Additional file 12 of Integrated omics analysis reveals sirtuin signaling is central to hepatic response to a high fructose diet
Additional file 12 of Integrated omics analysis reveals sirtuin signaling is central to hepatic response to a high fructose diet Open
Additional file 12. Metabolite Networks: Enrichment analysis of metabolites with p-value & 0.05.
View article: Additional file 6 of Integrated omics analysis reveals sirtuin signaling is central to hepatic response to a high fructose diet
Additional file 6 of Integrated omics analysis reveals sirtuin signaling is central to hepatic response to a high fructose diet Open
Additional file 6. Protein List: Proteins passing quality filters with ratios and p-values for HFr versus CON.
View article: Additional file 15 of Integrated omics analysis reveals sirtuin signaling is central to hepatic response to a high fructose diet
Additional file 15 of Integrated omics analysis reveals sirtuin signaling is central to hepatic response to a high fructose diet Open
Additional file 15. Gene, Protein, and Metabolite Pathways: Enrichment analysis combining genes, proteins, and metabolites with p-value < 0.05.
View article: Additional file 17 of Integrated omics analysis reveals sirtuin signaling is central to hepatic response to a high fructose diet
Additional file 17 of Integrated omics analysis reveals sirtuin signaling is central to hepatic response to a high fructose diet Open
Additional file 17. miRNAs passing quality filters and p‐values < 0.05 for HFr versus CON