Ellen Geens
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View article: Global analysis of neuropeptide receptor conservation across phylum Nematoda
Global analysis of neuropeptide receptor conservation across phylum Nematoda Open
The repertoire of C. elegans peptide GPCR orthologs varies across phylogenetic clades and several peptide GPCRs show broad conservation in the phylum Nematoda. Our work functionally characterizes the conserved receptors NPR-9 and NPR-16 as…
View article: azyx-1 is a new gene that overlaps with zyxin and affects its translation in C. elegans, impacting muscular integrity and locomotion
azyx-1 is a new gene that overlaps with zyxin and affects its translation in C. elegans, impacting muscular integrity and locomotion Open
Overlapping genes are widely prevalent; however, their expression and consequences are poorly understood. Here, we describe and functionally characterize a novel zyx-1 overlapping gene, azyx-1 , with distinct regulatory functions in Caenor…
View article: Yolk-deprived<i>Caenorhabditis elegans</i>secure brood size at the expense of competitive fitness
Yolk-deprived<i>Caenorhabditis elegans</i>secure brood size at the expense of competitive fitness Open
Oviparous animals support reproduction via the incorporation of yolk as a nutrient source into the eggs. In Caenorhabditis elegans , however, yolk proteins seem dispensable for fecundity, despite constituting the vast majority of the embry…
View article: A novel overlapping gene<i>azyx-1</i>affects the translation of zyxin in<i>C. elegans</i>
A novel overlapping gene<i>azyx-1</i>affects the translation of zyxin in<i>C. elegans</i> Open
Overlapping genes are widely prevalent, however, their expression and consequences are poorly understood. Here, we describe and functionally characterize a novel zyx-1 overlapping gene, azyx-1 , with distinct regulatory functions in C. ele…
View article: CEH-60/PBX regulates vitellogenesis and cuticle permeability through intestinal interaction with UNC-62/MEIS in Caenorhabditis elegans
CEH-60/PBX regulates vitellogenesis and cuticle permeability through intestinal interaction with UNC-62/MEIS in Caenorhabditis elegans Open
The onset of sexual maturity involves dramatic changes in physiology and gene expression in many animals. These include abundant yolk protein production in egg-laying species, an energetically costly process under extensive transcriptional…