Ellen Go
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View article: Multisystem inflammatory syndrome in children is a SARS-CoV-2 triggered Kawasaki disease
Multisystem inflammatory syndrome in children is a SARS-CoV-2 triggered Kawasaki disease Open
Background Multisystem Inflammatory Syndrome in Children (MIS-C) encompasses a spectrum of phenotypes: shock, Kawasaki disease (KD), and fever with hyperinflammation. Whether MIS-C is a new syndrome or SARS-CoV-2-triggered KD remains debat…
View article: Opportunities in childhood Sjögren’s disease: results from collaborative roundtable discussions
Opportunities in childhood Sjögren’s disease: results from collaborative roundtable discussions Open
International multidisciplinary collaboration and patient partnerships are essential to prioritize and address knowledge gaps in cSjD. This international collaborative workgroup recommends large prospective cohort studies to tackle
View article: ABCG2-Expressing Clonal Repopulating Endothelial Cells Serve to Form and Maintain Blood Vessels
ABCG2-Expressing Clonal Repopulating Endothelial Cells Serve to Form and Maintain Blood Vessels Open
BACKGROUND: Most organs are maintained lifelong by resident stem/progenitor cells. During development and regeneration, lineage-specific stem/progenitor cells can contribute to the growth or maintenance of different organs, whereas fully d…
View article: Kawasaki Disease and Systemic Juvenile Idiopathic Arthritis – Two Ends of the Same Spectrum
Kawasaki Disease and Systemic Juvenile Idiopathic Arthritis – Two Ends of the Same Spectrum Open
Kawasaki disease (KD) and systemic juvenile idiopathic arthritis (sJIA) are two distinct systemic inflammatory diseases of childhood. Each diagnosis is based on criteria, but numerous clinical features are overlapping. As no specific diagn…
View article: CanVasc Consensus Recommendations for the Management of Antineutrophil Cytoplasm Antibody-associated Vasculitis: 2020 Update
CanVasc Consensus Recommendations for the Management of Antineutrophil Cytoplasm Antibody-associated Vasculitis: 2020 Update Open
Objective In 2015, the Canadian Vasculitis Research Network (CanVasc) created recommendations for the management of antineutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV) in Canada. The current update aims to revise existin…
View article: Pediatric inflammatory multisystem syndrome temporally associated with COVID-19: a spectrum of diseases with many names
Pediatric inflammatory multisystem syndrome temporally associated with COVID-19: a spectrum of diseases with many names Open
KEY POINTS A 10-year-old previously healthy boy presented to the emergency department with 6 days of persistent fever; 4 days of abdominal pain, emesis and diarrhea; and bilateral nonpurulent conjunctivitis and red cracked lips. Four weeks…
View article: Mycophenolic acid induces senescence of vascular precursor cells
Mycophenolic acid induces senescence of vascular precursor cells Open
Our findings show that clinically relevant doses of MPA have potent anti-angiogenic and pro-senescent effects on vascular precursor cells in vitro, thus indicating that treatment with MPA can potentially affect vascular repair and regenera…