Ellen J. Thompson
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View article: Reciprocal longitudinal associations between symptoms of body dissatisfaction and disordered eating, self-harm and suicidal ideation
Reciprocal longitudinal associations between symptoms of body dissatisfaction and disordered eating, self-harm and suicidal ideation Open
Background Eating disorders are severe psychiatric conditions associated with high mortality rates, particularly among young people. These disorders often co-occur with self-harm and suicidal ideation, yet the temporal dynamics between the…
View article: Persistent Multi-System Impairments Detected by Wearable Monitoring in Long COVID Cases reporting Fatigue up to Three Years Post-Infection
Persistent Multi-System Impairments Detected by Wearable Monitoring in Long COVID Cases reporting Fatigue up to Three Years Post-Infection Open
Long COVID remains poorly understood and previous studies have mainly focused on describing symptoms or single-system health deficits in severe cases. In the CONVALESCENCE case-control study, 306 community-based participants (aged 57 [IQR …
View article: Software Application Profile: TIDAL—Tool to Implement Developmental Analysis of Longitudinal data
Software Application Profile: TIDAL—Tool to Implement Developmental Analysis of Longitudinal data Open
View article: Cohort profile: characterisation, determinants, mechanisms and consequences of the long-term effects of COVID-19 – providing the evidence base for health care services (CONVALESCENCE) in the UK
Cohort profile: characterisation, determinants, mechanisms and consequences of the long-term effects of COVID-19 – providing the evidence base for health care services (CONVALESCENCE) in the UK Open
Purpose The pathogenesis of the long-lasting symptoms which can follow an infection with the SARS-CoV-2 virus (‘long covid’) is not fully understood. The ‘COroNaVirus post-Acute Long-term EffectS: Constructing an evidENCE base’ (CONVALESCE…
View article: Lifetime history of depression and eating behaviours: a co-twin control study of the TwinsUK registry
Lifetime history of depression and eating behaviours: a co-twin control study of the TwinsUK registry Open
Our findings suggest the association between depression and eating can be partly explained by pre-existing genetic and environmental vulnerabilities. Understanding the mechanisms underlying this relationship could guide the development of …
View article: Peer problems and prosocial behaviours across development: Associations with anxiety and depression in emerging adulthood
Peer problems and prosocial behaviours across development: Associations with anxiety and depression in emerging adulthood Open
View article: Childhood vaccination trends among the Maasai nomadic pastoralists: Insights from a community-based vaccine registry in Kenya
Childhood vaccination trends among the Maasai nomadic pastoralists: Insights from a community-based vaccine registry in Kenya Open
Inequities in vaccination timeliness and coverage contribute to disparities in childhood health and survival. Regular, reliable estimates are needed to take programmatic action and track progress towards initiatives such as the Immunizatio…
View article: Dynein light chains 1 and 2 are auxiliary proteins of pH-sensitive Kir4.1 channels
Dynein light chains 1 and 2 are auxiliary proteins of pH-sensitive Kir4.1 channels Open
View article: Anxiety symptom trajectories across development: risk factors and outcomes
Anxiety symptom trajectories across development: risk factors and outcomes Open
Background: Anxiety is one of the most common conditions affecting young people. The onset and course of symptoms are highly variable across development and if left untreated, can lead to poor outcomes. We modelled trajectories of anxiety …
View article: ESPClust: unsupervised identification of modifiers for the effect size profile in omics association studies
ESPClust: unsupervised identification of modifiers for the effect size profile in omics association studies Open
Motivation High-throughput omics technologies have revolutionized the identification of associations between individual traits and underlying biological characteristics, but still use ‘one effect-size fits all’ approaches. While covariates…
View article: Social determinants of recovery from ongoing symptoms following COVID-19 in two UK longitudinal studies: a prospective cohort study
Social determinants of recovery from ongoing symptoms following COVID-19 in two UK longitudinal studies: a prospective cohort study Open
Introduction Social gradients in COVID-19 exposure and severity have been observed internationally. Whether combinations of pre-existing social factors, particularly those that confer cumulative advantage and disadvantage, affect recovery …
View article: COVID-19 and Mental Illnesses in Vaccinated and Unvaccinated People
COVID-19 and Mental Illnesses in Vaccinated and Unvaccinated People Open
Importance Associations have been found between COVID-19 and subsequent mental illness in both hospital- and population-based studies. However, evidence regarding which mental illnesses are associated with COVID-19 by vaccination status in…
View article: ESPClust: Unsupervised identification of modifiers for the effect size profile in omics association studies
ESPClust: Unsupervised identification of modifiers for the effect size profile in omics association studies Open
High-throughput omics technologies have revolutionised the identification of associations between individual traits and underlying biological characteristics, but still use ‘one effect-size fits all’ approaches. While covariates are often …
View article: TIDAL – Tool to Implement Developmental Analysis of Longitudinal data
TIDAL – Tool to Implement Developmental Analysis of Longitudinal data Open
Motivation Growth curve modelling is one method used to model trajectories of traits and behaviours over time. However, accessing, analysing and interpreting trajectories requires statistical expertise, thereby creating potential barriers …
View article: A novel <i>ABCC9</i> variant in a <scp>Greek</scp> family with <scp>Cantu</scp> syndrome affecting multiple generations highlights the functional role of the <scp>SUR2B NBD1</scp>
A novel <i>ABCC9</i> variant in a <span>Greek</span> family with <span>Cantu</span> syndrome affecting multiple generations highlights the functional role of the <span>SUR2B NBD1</span> Open
Cantu syndrome (CS) (OMIM #239850) is an autosomal dominant multiorgan system condition, associated with a characteristic facial phenotype, hypertrichosis, and multiple cardiovascular complications. CS is caused by gain‐of‐function (GOF) v…
View article: Self-report measures of fear learning and extinction and their association with internet-based cognitive behavioural therapy outcome
Self-report measures of fear learning and extinction and their association with internet-based cognitive behavioural therapy outcome Open
Despite the widespread use of cognitive-behavioural therapy (CBT), only about half of patients respond favourably. Understanding whether relevant psychological processes are associated with treatment response could help identify patients a…
View article: Anxiety symptom trajectories across development: risk factors and outcomes
Anxiety symptom trajectories across development: risk factors and outcomes Open
Background: Anxiety is one of the most common conditions affecting young people. The onset and course of symptoms are highly variable across development and if left untreated, can lead to poor outcomes. We modelled trajectories of anxiety …
View article: Anxiety symptom trajectories across development: risk factors and outcomes
Anxiety symptom trajectories across development: risk factors and outcomes Open
Background: Anxiety is one of the most common conditions affecting young people. The onset and course of symptoms are highly variable across development and if left untreated, can lead to poor outcomes. We modelled trajectories of anxiety …
View article: Social determinants of recovery from ongoing symptoms following COVID-19 in two UK longitudinal studies: a prospective cohort study
Social determinants of recovery from ongoing symptoms following COVID-19 in two UK longitudinal studies: a prospective cohort study Open
Background Social gradients in COVID-19 exposure, illness severity, and mortality have been observed in multiple international contexts. Whether pre-existing social factors affect recovery from ongoing symptoms following COVID-19 and long …
View article: Impact of COVID-19 on mental illness in vaccinated and unvaccinated people: a population-based cohort study in OpenSAFELY
Impact of COVID-19 on mental illness in vaccinated and unvaccinated people: a population-based cohort study in OpenSAFELY Open
Background COVID-19 is associated with subsequent mental illness in both hospital- and population-based studies. Evidence regarding effects of COVID-19 vaccination on mental health consequences of COVID-19 is limited. Methods With the appr…
View article: The relationship between weight-related indicators and depressive symptoms during adolescence and adulthood: results from two twin studies
The relationship between weight-related indicators and depressive symptoms during adolescence and adulthood: results from two twin studies Open
Background The association between weight and depressive symptoms is well established, but the direction of effects remains unclear. Most studies rely on body mass index (BMI) as the sole weight indicator, with few examining the aetiology …
View article: Living alone and mental health: parallel analyses in UK longitudinal population surveys and electronic health records prior to and during the COVID-19 pandemic
Living alone and mental health: parallel analyses in UK longitudinal population surveys and electronic health records prior to and during the COVID-19 pandemic Open
Background People who live alone experience greater levels of mental illness; however, it is unclear whether the COVID-19 pandemic had a disproportionately negative impact on this demographic. Objective To describe the mental health gap be…
View article: Ethnic differences in the indirect effects of the COVID-19 pandemic on clinical monitoring and hospitalisations for non-COVID conditions in England: a population-based, observational cohort study using the OpenSAFELY platform
Ethnic differences in the indirect effects of the COVID-19 pandemic on clinical monitoring and hospitalisations for non-COVID conditions in England: a population-based, observational cohort study using the OpenSAFELY platform Open
View article: A cross‐lagged twin study of emotional symptoms, social isolation and peer victimisation from early adolescence to emerging adulthood
A cross‐lagged twin study of emotional symptoms, social isolation and peer victimisation from early adolescence to emerging adulthood Open
Background Emotional symptoms, such as anxiety and depressive symptoms, are common during adolescence, often persist over time, and can precede the emergence of severe anxiety and depressive disorders. Studies suggest that a vicious cycle …
View article: Living alone and mental health: parallel analyses in longitudinal population surveys and electronic health records prior to and during the COVID-19 pandemic
Living alone and mental health: parallel analyses in longitudinal population surveys and electronic health records prior to and during the COVID-19 pandemic Open
Objectives To describe the mental health gap between those who live alone and those who live with others, and to examine whether the COVID-19 pandemic had an impact on this gap. Design Ten population based prospective cohort studies, and a…
View article: Antibody levels following vaccination against SARS-CoV-2: associations with post-vaccination infection and risk factors in two UK longitudinal studies
Antibody levels following vaccination against SARS-CoV-2: associations with post-vaccination infection and risk factors in two UK longitudinal studies Open
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody levels can be used to assess humoral immune responses following SARS-CoV-2 infection or vaccination, and may predict risk of future infection. Higher levels …
View article: Characterising patterns of COVID-19 and long COVID symptoms: evidence from nine UK longitudinal studies
Characterising patterns of COVID-19 and long COVID symptoms: evidence from nine UK longitudinal studies Open
Multiple studies across global populations have established the primary symptoms characterising Coronavirus Disease 2019 (COVID-19) and long COVID. However, as symptoms may also occur in the absence of COVID-19, a lack of appropriate contr…
View article: Author response: Antibody levels following vaccination against SARS-CoV-2: associations with post-vaccination infection and risk factors in two UK longitudinal studies
Author response: Antibody levels following vaccination against SARS-CoV-2: associations with post-vaccination infection and risk factors in two UK longitudinal studies Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Methods Results Discussion Data availability References Decision letter Author response Article and author information Metrics Abstract Background: Severe acut…
View article: Psychological distress, depression, anxiety, and life satisfaction following COVID-19 infection: evidence from 11 UK longitudinal population studies
Psychological distress, depression, anxiety, and life satisfaction following COVID-19 infection: evidence from 11 UK longitudinal population studies Open
View article: Inequalities in healthcare disruptions during the COVID-19 pandemic: evidence from 12 UK population-based longitudinal studies
Inequalities in healthcare disruptions during the COVID-19 pandemic: evidence from 12 UK population-based longitudinal studies Open
Objectives We investigated associations between multiple sociodemographic characteristics (sex, age, occupational social class, education and ethnicity) and self-reported healthcare disruptions during the early stages of the COVID-19 pande…