Ellen R. Richie
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View article: Insulin-like growth factor 2 as a driving force for exponential expansion and differentiation of the neonatal thymus
Insulin-like growth factor 2 as a driving force for exponential expansion and differentiation of the neonatal thymus Open
Like all organs, the thymus grows in size and function rapidly during development, but this growth comes to a halt after birth. However, the molecular mechanisms behind such a transition in the thymus remain obscure. Using single-cell RNA …
View article: Coordinated changes in thymic stromal and hematopoietic cells that define the perinatal to juvenile transition
Coordinated changes in thymic stromal and hematopoietic cells that define the perinatal to juvenile transition Open
SUMMARY T cells in the perinatal thymus have distinct phenotypes and functions that may be instructed by age-specific features of the microenvironment. We evaluated molecular and cellular profiles of thymic stromal cells, including thymic …
View article: Transposable elements regulate thymus development and function
Transposable elements regulate thymus development and function Open
Transposable elements (TEs) are repetitive sequences representing ~45% of the human and mouse genomes and are highly expressed by medullary thymic epithelial cells (mTECs). In this study, we investigated the role of TEs on T-cell developme…
View article: Reviewer #2 (Public Review): Transposable elements regulate thymus development and function
Reviewer #2 (Public Review): Transposable elements regulate thymus development and function Open
Transposable elements (TE) are repetitive sequences representing ∼45% of the human and mouse genomes and are highly expressed by medullary thymic epithelial cells (mTEC). In this study, we investigated the role of TEs on T-cell development…
View article: Author Response: Transposable elements regulate thymus development and function
Author Response: Transposable elements regulate thymus development and function Open
Transposable elements (TE) are repetitive sequences representing ∼45% of the human and mouse genomes and are highly expressed by medullary thymic epithelial cells (mTEC). In this study, we investigated the role of TEs on T-cell development…
View article: Reviewer #1 (Public Review): Transposable elements regulate thymus development and function
Reviewer #1 (Public Review): Transposable elements regulate thymus development and function Open
Transposable elements (TE) are repetitive sequences representing ∼45% of the human and mouse genomes and are highly expressed by medullary thymic epithelial cells (mTEC). In this study, we investigated the role of TEs on T-cell development…
View article: Transposable elements regulate thymus development and function
Transposable elements regulate thymus development and function Open
Transposable elements (TE) are repetitive sequences representing ∼45% of the human and mouse genomes and are highly expressed by medullary thymic epithelial cells (mTEC). In this study, we investigated the role of TEs on T-cell development…
View article: Transposable elements regulate thymus development and function
Transposable elements regulate thymus development and function Open
Transposable elements (TE) are repetitive sequences representing ∼45% of the human and mouse genomes and are highly expressed by medullary thymic epithelial cells (mTEC). In this study, we investigated the role of transposable elements (TE…
View article: Reviewer #1 (Public Review): Transposable elements regulate thymus development and function
Reviewer #1 (Public Review): Transposable elements regulate thymus development and function Open
Transposable elements (TE) are repetitive sequences representing ∼45% of the human and mouse genomes and are highly expressed by medullary thymic epithelial cells (mTEC). In this study, we investigated the role of transposable elements (TE…
View article: Transposable elements regulate thymus development and function
Transposable elements regulate thymus development and function Open
Transposable elements (TEs) are repetitive sequences representing ~45% of the human and mouse genomes and are highly expressed by medullary thymic epithelial cells (mTECs). In this study, we investigated the role of TEs on T-cell developme…
View article: Transposable elements regulate thymus development and function
Transposable elements regulate thymus development and function Open
Transposable elements (TE) are repetitive sequences representing ∼45% of the human and mouse genomes and are highly expressed by medullary thymic epithelial cells (mTEC). In this study, we investigated the role of TEs on T-cell development…
View article: The initial age‐associated decline in early T‐cell progenitors reflects fewer pre‐thymic progenitors and altered signals in the bone marrow and thymus microenvironments
The initial age‐associated decline in early T‐cell progenitors reflects fewer pre‐thymic progenitors and altered signals in the bone marrow and thymus microenvironments Open
Age‐related thymus involution results in decreased T‐cell production, contributing to increased susceptibility to pathogens and reduced vaccine responsiveness. Elucidating mechanisms underlying thymus involution will inform strategies to r…
View article: Supplementary Tables S1-S9 and Figures S1-S9 from Dimeric p53 Mutant Elicits Unique Tumor-Suppressive Activities through an Altered Metabolic Program
Supplementary Tables S1-S9 and Figures S1-S9 from Dimeric p53 Mutant Elicits Unique Tumor-Suppressive Activities through an Altered Metabolic Program Open
Table S1 shows predicted off target sites for p53TD mutant mice. Table S2 shows upregulated PPAR target genes in p53AD vs p53-null. Table S3 shows ATAC-seq and RNA-seq congruent genes in p53AD vs p53 null. Table S4 shows p53half site analy…
View article: Data from Dimeric p53 Mutant Elicits Unique Tumor-Suppressive Activities through an Altered Metabolic Program
Data from Dimeric p53 Mutant Elicits Unique Tumor-Suppressive Activities through an Altered Metabolic Program Open
Cancer-related alterations of the p53 tetramerization domain (TD) abrogate wild-type (WT) p53 function. They result in a protein that preferentially forms monomers or dimers, which are also normal p53 states under basal cellular conditions…
View article: Supplementary Tables S1-S9 and Figures S1-S9 from Dimeric p53 Mutant Elicits Unique Tumor-Suppressive Activities through an Altered Metabolic Program
Supplementary Tables S1-S9 and Figures S1-S9 from Dimeric p53 Mutant Elicits Unique Tumor-Suppressive Activities through an Altered Metabolic Program Open
Table S1 shows predicted off target sites for p53TD mutant mice. Table S2 shows upregulated PPAR target genes in p53AD vs p53-null. Table S3 shows ATAC-seq and RNA-seq congruent genes in p53AD vs p53 null. Table S4 shows p53half site analy…
View article: Data from Dimeric p53 Mutant Elicits Unique Tumor-Suppressive Activities through an Altered Metabolic Program
Data from Dimeric p53 Mutant Elicits Unique Tumor-Suppressive Activities through an Altered Metabolic Program Open
Cancer-related alterations of the p53 tetramerization domain (TD) abrogate wild-type (WT) p53 function. They result in a protein that preferentially forms monomers or dimers, which are also normal p53 states under basal cellular conditions…
View article: Supplementary Tables S1-S9 and Figures S1-S9 from Dimeric p53 Mutant Elicits Unique Tumor-Suppressive Activities through an Altered Metabolic Program
Supplementary Tables S1-S9 and Figures S1-S9 from Dimeric p53 Mutant Elicits Unique Tumor-Suppressive Activities through an Altered Metabolic Program Open
Table S1 shows predicted off target sites for p53TD mutant mice. Table S2 shows upregulated PPAR target genes in p53AD vs p53-null. Table S3 shows ATAC-seq and RNA-seq congruent genes in p53AD vs p53 null. Table S4 shows p53half site analy…
View article: Data from Dimeric p53 Mutant Elicits Unique Tumor-Suppressive Activities through an Altered Metabolic Program
Data from Dimeric p53 Mutant Elicits Unique Tumor-Suppressive Activities through an Altered Metabolic Program Open
Cancer-related alterations of the p53 tetramerization domain (TD) abrogate wild-type (WT) p53 function. They result in a protein that preferentially forms monomers or dimers, which are also normal p53 states under basal cellular conditions…
View article: Dimeric p53 Mutant Elicits Unique Tumor-Suppressive Activities through an Altered Metabolic Program
Dimeric p53 Mutant Elicits Unique Tumor-Suppressive Activities through an Altered Metabolic Program Open
Cancer-related alterations of the p53 tetramerization domain (TD) abrogate wild-type (WT) p53 function. They result in a protein that preferentially forms monomers or dimers, which are also normal p53 states under basal cellular conditions…
View article: Supplementary Tables S1-S9 and Figures S1-S9 from Dimeric p53 Mutant Elicits Unique Tumor-Suppressive Activities through an Altered Metabolic Program
Supplementary Tables S1-S9 and Figures S1-S9 from Dimeric p53 Mutant Elicits Unique Tumor-Suppressive Activities through an Altered Metabolic Program Open
Table S1 shows predicted off target sites for p53TD mutant mice. Table S2 shows upregulated PPAR target genes in p53AD vs p53-null. Table S3 shows ATAC-seq and RNA-seq congruent genes in p53AD vs p53 null. Table S4 shows p53half site analy…
View article: Central tolerance is impaired in the middle‐aged thymic environment
Central tolerance is impaired in the middle‐aged thymic environment Open
One of the earliest hallmarks of immune aging is thymus involution, which not only reduces the number of newly generated and exported T cells, but also alters the composition and organization of the thymus microenvironment. Thymic T‐cell e…
View article: An early decline in ETPs reflects fewer pre-thymic progenitors and altered signals from the thymus microenvironment
An early decline in ETPs reflects fewer pre-thymic progenitors and altered signals from the thymus microenvironment Open
Age-related thymus involution results in decreased T-cell production, contributing to increased susceptibility to pathogens. Elucidating mechanisms underlying involution will inform strategies to restore thymopoiesis. The thymus is coloniz…
View article: Central tolerance is impaired in the middle-aged thymic environment
Central tolerance is impaired in the middle-aged thymic environment Open
Summary One of the earliest hallmarks of immune aging is thymus involution, which not only reduces the number of newly generated and exported T cells, but also alters the composition and organization of the thymic microenvironment. Thymic …
View article: Age-Related Changes in Thymic Central Tolerance
Age-Related Changes in Thymic Central Tolerance Open
Thymic epithelial cells (TECs) and hematopoietic antigen presenting cells (HAPCs) in the thymus microenvironment provide essential signals to self-reactive thymocytes that induce either negative selection or generation of regulatory T cell…
View article: Polycomb Repressive Complex 2 is essential for development and maintenance of a functional TEC compartment
Polycomb Repressive Complex 2 is essential for development and maintenance of a functional TEC compartment Open
Thymic epithelial cells (TEC) are essential for thymocyte differentiation and repertoire selection. Despite their indispensable role in generating functional T cells, the molecular mechanisms that orchestrate TEC development from endoderma…
View article: Tissue-specific roles for sonic hedgehog signaling in establishing thymus and parathyroid organ fate
Tissue-specific roles for sonic hedgehog signaling in establishing thymus and parathyroid organ fate Open
The thymus and parathyroids develop from third pharyngeal pouch (3rd pp) endoderm. Our previous studies show that Shh null mice have smaller, aparathyroid primordia in which thymus fate specification extends into the pharynx. SHH signaling…