Elizabeth Smith
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View article: A Pilot Study: Comparative Effects of Green Tea Extract and Duloxetine on Oxaliplatin-Induced Allodynia in a Murine Model
A Pilot Study: Comparative Effects of Green Tea Extract and Duloxetine on Oxaliplatin-Induced Allodynia in a Murine Model Open
Background/Objectives: The purpose of this preclinical pilot study was to explore the potential of green tea extract (GTE) to mitigate and/or prevent oxaliplatin-induced allodynia and axonal damage in rats, when compared to duloxetine (DLX…
View article: Parents providing palliative care for children with cancer
Parents providing palliative care for children with cancer Open
Parents of children with cancer provide paediatric palliative care (PPC). However, the activities they perform remain underexplored, especially in low- and middle-income countries (LMICs) where the care heavily relies on family involvement…
View article: Impact of Trauma Verification Level on Management and Outcomes of Combined Traumatic Brain and Solid Organ Injuries: An NTDB Retrospective Review
Impact of Trauma Verification Level on Management and Outcomes of Combined Traumatic Brain and Solid Organ Injuries: An NTDB Retrospective Review Open
Background Level-I and level-II trauma centers are required to offer equivalent resources since “The Orange Book.” This study evaluates differences between level-I and level-II management of solid organ injury (SOI) with traumatic brain in…
View article: Understanding the association between fatigue and neurocognitive functioning in patients with glioma: A cross-sectional multinational study
Understanding the association between fatigue and neurocognitive functioning in patients with glioma: A cross-sectional multinational study Open
Background Fatigue and neurocognitive impairment are highly prevalent in patients with glioma, significantly impacting health-related quality of life. Despite the presumed association between these two factors, evidence remains sparse. The…
View article: Patient-targeted education (ePRO-E) to increase ePRO intent within an Alliance clinical trial (A221805-SI1)
Patient-targeted education (ePRO-E) to increase ePRO intent within an Alliance clinical trial (A221805-SI1) Open
Background The Patient Cloud ePRO app was adopted by the National Cancer Institute National Clinical Trials Network (NCTN) to facilitate capturing electronic patient-reported (ePRO) outcome data, but use has been low. The study objectives …
View article: Viability and Outcomes With Revascularization or Medical Therapy in Ischemic Ventricular Dysfunction
Viability and Outcomes With Revascularization or Medical Therapy in Ischemic Ventricular Dysfunction Open
Importance In the Revascularization for Ischemic Ventricular Dysfunction (REVIVED-BCIS2) trial, percutaneous coronary intervention (PCI) did not improve outcomes for patients with ischemic left ventricular dysfunction. Whether myocardial v…
View article: Electronic Patient-Reported Outcome Data Collection Systems in Oncology Clinical Trials: A Survey of Clinical Research Professionals (an Alliance Study)
Electronic Patient-Reported Outcome Data Collection Systems in Oncology Clinical Trials: A Survey of Clinical Research Professionals (an Alliance Study) Open
PURPOSE To describe clinical research professionals (CRPs)’ experiences with electronic patient-reported outcome (ePRO) data collection systems in oncology clinical trials and identify correlates of CRPs' attitude toward technology. METHOD…
View article: Characterizing Subcortical Structural Heterogeneity in Autism
Characterizing Subcortical Structural Heterogeneity in Autism Open
Autism presents with significant phenotypic and neuroanatomical heterogeneity, and neuroimaging studies of the thalamus, globus pallidus and striatum in autism have produced inconsistent and contradictory results. These structures are crit…
View article: Unfolding parental knowledge, attitudes, and beliefs toward palliative care for children with cancer
Unfolding parental knowledge, attitudes, and beliefs toward palliative care for children with cancer Open
Background Parents’ views toward pediatric palliative care (PPC) remain underexplored, especially in low/middle‐income countries where care relies heavily on families. A better understanding of parents’ perspectives would inform strategies…
View article: Adolescents and Young Adults With Sickle Cell Disease
Adolescents and Young Adults With Sickle Cell Disease Open
Objectives: Some patients with sickle cell disease (SCD) have features of nociplastic pain. While research suggests that many patients with nociplastic pain consume more opioids due to opioid nonresponsiveness, little is known about the im…
View article: Supplementary Data from SCH 2047069, a Novel Oral Kinesin Spindle Protein Inhibitor, Shows Single-Agent Antitumor Activity and Enhances the Efficacy of Chemotherapeutics
Supplementary Data from SCH 2047069, a Novel Oral Kinesin Spindle Protein Inhibitor, Shows Single-Agent Antitumor Activity and Enhances the Efficacy of Chemotherapeutics Open
Supplementary Tables 1, 2, and 3 and Supplementary Figures 1 and 2
View article: Data from SCH 2047069, a Novel Oral Kinesin Spindle Protein Inhibitor, Shows Single-Agent Antitumor Activity and Enhances the Efficacy of Chemotherapeutics
Data from SCH 2047069, a Novel Oral Kinesin Spindle Protein Inhibitor, Shows Single-Agent Antitumor Activity and Enhances the Efficacy of Chemotherapeutics Open
Kinesin spindle protein (KSP) is a mitotic kinesin required for the formation of the bipolar mitotic spindle, and inhibition of this motor protein results in mitotic arrest and cell death. KSP inhibitors show preclinical antitumor activity…
View article: Figure S2 from Paclitaxel Plasma Concentration after the First Infusion Predicts Treatment-Limiting Peripheral Neuropathy
Figure S2 from Paclitaxel Plasma Concentration after the First Infusion Predicts Treatment-Limiting Peripheral Neuropathy Open
Supplementary Figure 2: Paclitaxel Exposure in Patients Who Did or Did Not Experience Peripheral Neuropathy-Induced Treatment Disruption. Patients who experienced PN-induced treatment disruption had greater median paclitaxel Tc>0.05 than p…
View article: Data from Paclitaxel Plasma Concentration after the First Infusion Predicts Treatment-Limiting Peripheral Neuropathy
Data from Paclitaxel Plasma Concentration after the First Infusion Predicts Treatment-Limiting Peripheral Neuropathy Open
Purpose: Paclitaxel exposure, specifically the maximum concentration (Cmax) and amount of time the concentration remains above 0.05 μmol/L (Tc>0.05), has been associated with the occurrence of paclitaxel-induced peripheral neuropathy. The …
View article: Data from SCH 2047069, a Novel Oral Kinesin Spindle Protein Inhibitor, Shows Single-Agent Antitumor Activity and Enhances the Efficacy of Chemotherapeutics
Data from SCH 2047069, a Novel Oral Kinesin Spindle Protein Inhibitor, Shows Single-Agent Antitumor Activity and Enhances the Efficacy of Chemotherapeutics Open
Kinesin spindle protein (KSP) is a mitotic kinesin required for the formation of the bipolar mitotic spindle, and inhibition of this motor protein results in mitotic arrest and cell death. KSP inhibitors show preclinical antitumor activity…
View article: Supplementary Data from SCH 2047069, a Novel Oral Kinesin Spindle Protein Inhibitor, Shows Single-Agent Antitumor Activity and Enhances the Efficacy of Chemotherapeutics
Supplementary Data from SCH 2047069, a Novel Oral Kinesin Spindle Protein Inhibitor, Shows Single-Agent Antitumor Activity and Enhances the Efficacy of Chemotherapeutics Open
Supplementary Tables 1, 2, and 3 and Supplementary Figures 1 and 2
View article: Figure S2 from Paclitaxel Plasma Concentration after the First Infusion Predicts Treatment-Limiting Peripheral Neuropathy
Figure S2 from Paclitaxel Plasma Concentration after the First Infusion Predicts Treatment-Limiting Peripheral Neuropathy Open
Supplementary Figure 2: Paclitaxel Exposure in Patients Who Did or Did Not Experience Peripheral Neuropathy-Induced Treatment Disruption. Patients who experienced PN-induced treatment disruption had greater median paclitaxel Tc>0.05 than p…
View article: Figure S1 from Paclitaxel Plasma Concentration after the First Infusion Predicts Treatment-Limiting Peripheral Neuropathy
Figure S1 from Paclitaxel Plasma Concentration after the First Infusion Predicts Treatment-Limiting Peripheral Neuropathy Open
Supplementary Figure 1: Consort Diagram. Of the sixty-five patients enrolled on the prospective observational clinical trial (UMCC2014.002), 60 were eligible for analysis. Analyses of each exposure metric used a subset of these patients du…
View article: Figure S1 from Paclitaxel Plasma Concentration after the First Infusion Predicts Treatment-Limiting Peripheral Neuropathy
Figure S1 from Paclitaxel Plasma Concentration after the First Infusion Predicts Treatment-Limiting Peripheral Neuropathy Open
Supplementary Figure 1: Consort Diagram. Of the sixty-five patients enrolled on the prospective observational clinical trial (UMCC2014.002), 60 were eligible for analysis. Analyses of each exposure metric used a subset of these patients du…
View article: Data from Paclitaxel Plasma Concentration after the First Infusion Predicts Treatment-Limiting Peripheral Neuropathy
Data from Paclitaxel Plasma Concentration after the First Infusion Predicts Treatment-Limiting Peripheral Neuropathy Open
Purpose: Paclitaxel exposure, specifically the maximum concentration (Cmax) and amount of time the concentration remains above 0.05 μmol/L (Tc>0.05), has been associated with the occurrence of paclitaxel-induced peripheral neuropathy. The …
View article: Comparison of Pre-Diagnosis Physical Activity and Its Correlates between Lung and Other Cancer Patients: Accelerometer Data from the UK Biobank Prospective Cohort
Comparison of Pre-Diagnosis Physical Activity and Its Correlates between Lung and Other Cancer Patients: Accelerometer Data from the UK Biobank Prospective Cohort Open
Purpose: Physical activity (PA) plays an important role in health outcomes for people with cancer, and pre-diagnosis PA influences PA behaviors after cancer treatment. Less is known about the PA of lung cancer patients, and the strong hist…
View article: The Primary Care-Population Medicine (PC-PM) Program at Brown University – Early Outcomes
The Primary Care-Population Medicine (PC-PM) Program at Brown University – Early Outcomes Open
CONTEXT: The Primary Care – Population Medicine Program at Brown University (PC-PM), the first of its kind, awards both a Medical Degree and a Master of Science in Population Medicine, and seamlessly integrates Health Systems Science (HSS)…
View article: P69 COVID vaccine uptake in young persons on immunosuppression under the care of tertiary paediatric rheumatology service
P69 COVID vaccine uptake in young persons on immunosuppression under the care of tertiary paediatric rheumatology service Open
Introduction/Background COVID-19 disease, caused by SARS-CoV-2 virus, first emerged as a presentation of severe respiratory disease in 2019. Although children exhibit mild disease, concerns were raised about serious infection in immunocomp…
View article: Rib fixation in patients with severe rib fractures and pulmonary contusions: Is it safe?
Rib fixation in patients with severe rib fractures and pulmonary contusions: Is it safe? Open
BACKGROUND Pulmonary contusion has been considered a contraindication to surgical stabilization of rib fractures (SSRFs). This study aimed to evaluate the association between pulmonary contusion severity and outcomes after SSRF. We hypothe…