Ellen Tedaldi
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View article: HIV viral exposure and mortality in a multicenter ambulatory HIV adult cohort, United States, 1995-2016
HIV viral exposure and mortality in a multicenter ambulatory HIV adult cohort, United States, 1995-2016 Open
The aim of this study was to identify viral exposure (VE) measures and their relationship to mortality risk among persons with HIV.Prospective multicenter observational study to compare VE formulae.Eligible participants initiated first com…
View article: Emerging from the shadows: Trends in HIV ambulatory care, viral load testing, and viral suppression in a U.S. HIV cohort, 2019–2022: Impact of COVID-19 pandemic
Emerging from the shadows: Trends in HIV ambulatory care, viral load testing, and viral suppression in a U.S. HIV cohort, 2019–2022: Impact of COVID-19 pandemic Open
This article aimed at analyzing the acute impact and the longer-term recovery of COVID-19 pandemic effects on clinical encounter types, HIV viral load (VL) testing, and suppression (HIV VL < 200 copies/mL). This study was a longitudinal co…
View article: Incidence of Hyperlipidemia among Adults Initiating Antiretroviral Therapy in the HIV Outpatient Study (HOPS), USA, 2007–2021
Incidence of Hyperlipidemia among Adults Initiating Antiretroviral Therapy in the HIV Outpatient Study (HOPS), USA, 2007–2021 Open
Current U.S. guidelines recommend integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) as initial treatment for people with HIV (PWH). We assessed long-term effects of INSTI use on lipid profiles in routine HIV ca…
View article: Weight Gain and Metabolic Effects in Persons With HIV Who Switch to ART Regimens Containing Integrase Inhibitors or Tenofovir Alafenamide
Weight Gain and Metabolic Effects in Persons With HIV Who Switch to ART Regimens Containing Integrase Inhibitors or Tenofovir Alafenamide Open
Background: The timing and magnitude of antiretroviral therapy–associated weight change attributions are unclear. Setting: HIV Outpatient Study participants. Methods: We analyzed 2007–2018 records of virally suppressed (VS) persons without…
View article: Disparities in Treatment with Direct-Acting Hepatitis C Virus Antivirals Persist Among Adults Coinfected with HIV and Hepatitis C Virus in US Clinics, 2010–2018
Disparities in Treatment with Direct-Acting Hepatitis C Virus Antivirals Persist Among Adults Coinfected with HIV and Hepatitis C Virus in US Clinics, 2010–2018 Open
Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) coinfection carries substantial risk for all-cause mortality and liver-related morbidity and mortality, yet many persons coinfected with HIV/HCV remain untreated for HCV. We ex…
View article: HIV viral exposure and mortality in a multicenter ambulatory HIV adult cohort, United States, 1995–2016
HIV viral exposure and mortality in a multicenter ambulatory HIV adult cohort, United States, 1995–2016 Open
The aim of this study was to identify viral exposure (VE) measures and their relationship to mortality risk among persons with HIV. Prospective multicenter observational study to compare VE formulae. Eligible participants initiated first c…
View article: Hepatitis C Virus Testing Among Men With Human Immunodeficiency Virus Who Have Sex With Men: Temporal Trends and Racial/Ethnic Disparities
Hepatitis C Virus Testing Among Men With Human Immunodeficiency Virus Who Have Sex With Men: Temporal Trends and Racial/Ethnic Disparities Open
Background National guidelines recommend that sexually active people with human immunodeficiency virus (PWH) who are men who have sex with men (MSM) be tested for hepatitis C virus (HCV) infection at least annually. Hepatitis C virus testi…
View article: Impact of Age on Retention in Care and Viral Suppression
Impact of Age on Retention in Care and Viral Suppression Open
Retention in care is important for all HIV-infected persons and is strongly associated with initiation of antiretroviral therapy and viral suppression. However, it is unclear how retention in care and age interact to effect viral suppressi…
View article: Virologic and immunologic response to HAART, by age and regimen class
Virologic and immunologic response to HAART, by age and regimen class Open
To determine the impact of age and initial HAART regimen class on virologic and immunologic response within 24 months after initiation.
View article: The HIV Outpatient Study—25 Years of HIV Patient Care and Epidemiologic Research
The HIV Outpatient Study—25 Years of HIV Patient Care and Epidemiologic Research Open
Background The clinical epidemiology of treated HIV infection in the United States has dramatically changed in the past 25 years. Few sources of longitudinal data exist for people with HIV (PWH) spanning that period. Cohort data enable inv…
View article: Perceptions of Long-Acting Injectable Antiretroviral Treatment Regimens in a United States Urban Academic Medical Center
Perceptions of Long-Acting Injectable Antiretroviral Treatment Regimens in a United States Urban Academic Medical Center Open
Patient acceptance of long-acting injectable antiretroviral (LAI-ARV) HIV-1 regimens will determine uptake. Although previous literature reports high satisfaction, these data stem from clinical trials subject to selection bias. This cross-…
View article: Chlamydia and Gonorrhea Incidence and Testing Among Patients in the Human Immunodeficiency Virus Outpatient Study (HOPS), 2007−2017
Chlamydia and Gonorrhea Incidence and Testing Among Patients in the Human Immunodeficiency Virus Outpatient Study (HOPS), 2007−2017 Open
Background Although chlamydia (CT) and gonorrhea (GC) infections are increasing in the United States, there are limited data on their incidence, testing rates, and associated risk factors among persons living with HIV (PLWH), including by …
View article: 2498. Perceptions of Injectable Antiretrovirals in an Urban HIV Clinic
2498. Perceptions of Injectable Antiretrovirals in an Urban HIV Clinic Open
Background Although new injectable antiretrovirals (ARV) for HIV may soon be available, there is little research on patient preferences. We examined perceptions of injectable ARV among persons living with HIV (PLWH). Methods This cross-sec…
View article: Non-AIDS comorbidity burden differs by sex, race, and insurance type in aging adults in HIV care
Non-AIDS comorbidity burden differs by sex, race, and insurance type in aging adults in HIV care Open
Age-related increases existed in prevalence and number of NACMs, with disproportionate burden among women, NHBs, and the publicly insured. These groups should be targeted for screening and prevention strategies aimed at NACM reduction.
View article: Sleep disturbances in HIV-infected patients associated with depression and high risk of obstructive sleep apnea
Sleep disturbances in HIV-infected patients associated with depression and high risk of obstructive sleep apnea Open
Objective: To evaluate sleep disturbances in a diverse, contemporary HIV-positive patient cohort and to identify demographic, clinical, and immune correlates. Methods: A convenience sample of 176 patients from a racially and ethnically div…
View article: C - 16The Relationship Between Subjective Cognitive Function and Neuropsychological Performance in an Urban HIV+ Population
C - 16The Relationship Between Subjective Cognitive Function and Neuropsychological Performance in an Urban HIV+ Population Open
Objective: There are discrepancies in the literature as to whether perceived cognitive difficulties correlate with observed deficits on neuropsychological measures.Individuals with human immunodeficiency virus (HIV) are at an increased ris…
View article: Time spent with HIV viral load above 1500 copies/ml among patients in HIV care, 2000–2014
Time spent with HIV viral load above 1500 copies/ml among patients in HIV care, 2000–2014 Open
pPT above 1500 declined during 2000-2014. Results support decreasing HIV transmission risk from persons in HIV care over the last decade, and the need to focus interventions on patient groups more consistently viremic.
View article: Risk Factors and Incidence of Syphilis in Human Immunodeficiency Virus (HIV)–Infected Persons: The HIV Outpatient Study, 1999–2015
Risk Factors and Incidence of Syphilis in Human Immunodeficiency Virus (HIV)–Infected Persons: The HIV Outpatient Study, 1999–2015 Open
The increases in the syphilis incidence rate through 2015 reflect ongoing sexual risk and highlight the need for enhanced prevention interventions among HIV-infected patients in care.
View article: Correction: Trends of racial and ethnic disparities in virologic suppression among women in the HIV Outpatient Study, USA, 2010-2015
Correction: Trends of racial and ethnic disparities in virologic suppression among women in the HIV Outpatient Study, USA, 2010-2015 Open
[This corrects the article DOI: 10.1371/journal.pone.0189973.].
View article: Trends of racial and ethnic disparities in virologic suppression among women in the HIV Outpatient Study, USA, 2010-2015
Trends of racial and ethnic disparities in virologic suppression among women in the HIV Outpatient Study, USA, 2010-2015 Open
In the United States, women accounted for 19% of new HIV diagnoses in 2015 and were less likely to reach virologic suppression when compared to men. We assessed trends and disparities in virologic suppression among HIV-positive women to in…
View article: HIV RNA Suppression during and after Pregnancy among Women in the HIV Outpatient Study, 1996 to 2015
HIV RNA Suppression during and after Pregnancy among Women in the HIV Outpatient Study, 1996 to 2015 Open
Objective: To examine HIV viral suppression during/after pregnancy. Design: Prospective observational cohort. Methods: We identified pregnancies from 1996 to 2015. We examined HIV RNA viral load (VL), VL suppression (≤500 copies/mL), and a…
View article: Incidence of Hepatitis C Virus Infection in the Human Immunodeficiency Virus Outpatient Study Cohort, 2000–2013
Incidence of Hepatitis C Virus Infection in the Human Immunodeficiency Virus Outpatient Study Cohort, 2000–2013 Open
Background There are few recent studies of incident hepatitis C virus (HCV) infection among human immunodeficiency virus (HIV)-infected patients in the United States. Methods We studied HIV Outpatient Study (HOPS) participants seen in 9 HI…
View article: Correction: Corrigendum: Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9 Gene Editing
Correction: Corrigendum: Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9 Gene Editing Open
Scientific Reports 6: Article number: 22555; published online: 04 March 2016; updated: 07 July 2016 The Competing financial interests statement in this Article should read: “KK, WH, RK, and YZ are named inventors on patents that cover the …
View article: Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9 Gene Editing
Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9 Gene Editing Open
We employed an RNA-guided CRISPR/Cas9 DNA editing system to precisely remove the entire HIV-1 genome spanning between 5′ and 3′ LTRs of integrated HIV-1 proviral DNA copies from latently infected human CD4+ T-cells. Comprehensive assessmen…