Elliot H. Smith
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View article: Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala
Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala Open
Direct electrical stimulation of the human brain has been used for numerous clinical and scientific applications. At present, however, little is known about how intracranial stimulation affects activity at the microscale. In this study, we…
View article: Author response: Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala
Author response: Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala Open
View article: Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala
Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala Open
Direct electrical stimulation of the human brain has been used for numerous clinical and scientific applications. At present, however, little is known about how intracranial stimulation affects activity at the microscale. In this study, we…
View article: Author response: Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala
Author response: Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala Open
View article: Eye movements organize excitability state, information coding and network connectivity in the human hippocampus
Eye movements organize excitability state, information coding and network connectivity in the human hippocampus Open
Natural vision is an active sensing process that entails frequent eye movements to sample the environment. Nonetheless vision is often studied using passive viewing with eye position held constant. Using closed-loop eye-tracking, with sacc…
View article: Frontotemporal bursting supports human working memory
Frontotemporal bursting supports human working memory Open
Cortical neural activity varies dynamically during memory periods, when relevant information is not present in the environment. But how those dynamics are related to a code defining working memory (WM) performance is not known. Recent data…
View article: Cell-type-specific responses to single-pulse electrical stimulation of the human brain
Cell-type-specific responses to single-pulse electrical stimulation of the human brain Open
This study bridges a gap in the neuromodulation field by examining the single-unit, cell-type-specific FR responses to direct electrical stimulation of the human brain. We show that low-frequency, single-pulse stimulation broadly elicits s…
View article: Human brain network control of creativity
Human brain network control of creativity Open
Summary The ability to think creatively is fundamental to human cognition, shaping how we interact with the world and navigate complex problems. Creativity depends on the interaction of multiple large-scale brain networks, but how these ne…
View article: Rodent and human seizures demonstrate a dynamic interplay with spreading depolarizations
Rodent and human seizures demonstrate a dynamic interplay with spreading depolarizations Open
View article: Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala
Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala Open
Direct electrical stimulation of the human brain has been used for numerous clinical and scientific applications. Previously, we demonstrated that intracranial theta burst stimulation (TBS) of the basolateral amygdala (BLA) can enhance dec…
View article: Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala
Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala Open
Direct electrical stimulation of the human brain has been used for numerous clinical and scientific applications. At present, however, little is known about how intracranial stimulation affects activity at the microscale. In this study, we…
View article: Protocol for detecting and analyzing non-oscillatory traveling waves from high-spatiotemporal-resolution human electrophysiological recordings
Protocol for detecting and analyzing non-oscillatory traveling waves from high-spatiotemporal-resolution human electrophysiological recordings Open
Innovations in electrophysiological recordings and computational analytic techniques enable high-resolution analysis of neural traveling waves. Here, we present a protocol for the detection and analysis of traveling waves from multi-day mi…
View article: A neuronal code for object representation and memory in the human amygdala and hippocampus
A neuronal code for object representation and memory in the human amygdala and hippocampus Open
How the brain encodes, recognizes, and memorizes general visual objects is a fundamental question in neuroscience. Here, we investigated the neural processes underlying visual object perception and memory by recording from 3173 single neur…
View article: On brain stimulation in epilepsy
On brain stimulation in epilepsy Open
Brain stimulation has, for many decades, been considered as a potential solution for the unmet needs of the many people living with drug-resistant epilepsy. Clinically, there are several different approaches in use, including vagus nerve s…
View article: Cell-type specific responses to single-pulse electrical stimulation of the human brain
Cell-type specific responses to single-pulse electrical stimulation of the human brain Open
Neuromodulation techniques, such as deep brain stimulation, intraoperative brain mapping, and responsive neurostimulation, use electricity to alter brain activity. Despite daily clinical use in thousands of patients, it remains fundamental…
View article: Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala
Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala Open
Direct electrical stimulation of the human brain has been used for numerous clinical and scientific applications. At present, however, little is known about how intracranial stimulation affects activity at the microscale. In this study, we…
View article: More widespread and rigid neuronal representation of reward expectation underlies impulsive choices
More widespread and rigid neuronal representation of reward expectation underlies impulsive choices Open
Summary Impulsive choices prioritize smaller, more immediate rewards over larger, delayed, or potentially uncertain rewards. Impulsive choices are a critical aspect of substance use disorders and maladaptive decision-making across the life…
View article: A neuronal code for object representation and memory in the human amygdala and hippocampus
A neuronal code for object representation and memory in the human amygdala and hippocampus Open
How the brain encodes, recognizes, and memorizes general visual objects is a fundamental question in neuroscience. Here, we investigated the neural processes underlying visual object perception and memory by recording from 3173 single neur…
View article: Circadian changes in aperiodic activity are correlated with seizure reduction in patients with mesial temporal lobe epilepsy treated with responsive neurostimulation
Circadian changes in aperiodic activity are correlated with seizure reduction in patients with mesial temporal lobe epilepsy treated with responsive neurostimulation Open
Objectives Responsive neurostimulation (RNS) is an established therapy for drug‐resistant epilepsy that delivers direct electrical brain stimulation in response to detected epileptiform activity. However, despite an overall reduction in se…
View article: Aberrant fast spiking interneuronal activity precedes seizure transitions in humans
Aberrant fast spiking interneuronal activity precedes seizure transitions in humans Open
There is active debate regarding how GABAergic function changes during seizure initiation and propagation, and whether interneuronal activity drives or impedes the pathophysiology. Here, we track cell-type specific firing during spontaneou…
View article: Characterization of spatiotemporal dynamics of binary and graded tonic pain in humans using intracranial recordings
Characterization of spatiotemporal dynamics of binary and graded tonic pain in humans using intracranial recordings Open
Pain is a complex experience involving sensory, emotional, and cognitive aspects, and multiple networks manage its processing in the brain. Examining how pain transforms into a behavioral response can shed light on the networks’ relationsh…
View article: Closed-loop stimulation in periods with less epileptiform activity drives improved epilepsy outcomes
Closed-loop stimulation in periods with less epileptiform activity drives improved epilepsy outcomes Open
In patients with drug-resistant epilepsy, electrical stimulation of the brain in response to epileptiform activity can make seizures less frequent and debilitating. This therapy, known as closed-loop responsive neurostimulation (RNS), aims…
View article: Pretrial predictors of conflict response efficacy in the human prefrontal cortex
Pretrial predictors of conflict response efficacy in the human prefrontal cortex Open
View article: Cell-type specific and multiscale dynamics of human focal seizures in limbic structures
Cell-type specific and multiscale dynamics of human focal seizures in limbic structures Open
The relationship between clinically accessible epileptic biomarkers and neuronal activity underlying the transition to seizure is complex, potentially leading to imprecise delineation of epileptogenic brain areas. In particular, the patter…
View article: Macroscale traveling waves evoked by single-pulse stimulation of the human brain
Macroscale traveling waves evoked by single-pulse stimulation of the human brain Open
Understanding the spatiotemporal dynamics of neural signal propagation is fundamental to unraveling the complexities of brain function. Emerging evidence suggests that cortico-cortical evoked potentials (CCEPs) resulting from single-pulse …
View article: Psychophysical pain encoding in the cingulate cortex predicts responsiveness of electrical stimulation
Psychophysical pain encoding in the cingulate cortex predicts responsiveness of electrical stimulation Open
Background The anterior cingulate cortex (ACC) plays an important role in the cognitive and emotional processing of pain. Prior studies have used deep brain stimulation (DBS) to treat chronic pain, but results have been inconsistent. This …
View article: “Characterization of spatiotemporal dynamics of binary and graded tonic pain in humans using intracranial recordings”
“Characterization of spatiotemporal dynamics of binary and graded tonic pain in humans using intracranial recordings” Open
Pain is a complex experience involving sensory, emotional, and cognitive aspects, and multiple networks manage its processing in the brain. Examining how pain transforms into a behavioral response can shed light on the networks’ relationsh…
View article: Cell-type specific and multiscale dynamics of human focal seizures in limbic structures
Cell-type specific and multiscale dynamics of human focal seizures in limbic structures Open
The relationship between clinically accessible epileptic biomarkers and neuronal activity underlying the seizure transition is complex, potentially leading to imprecise delineation of epileptogenic brain areas. In particular, the pattern o…
View article: Increased neural encoding of reward expectation underlies impulsive choices
Increased neural encoding of reward expectation underlies impulsive choices Open
View article: Human prefrontal neurons encode economic risk and risk prediction error
Human prefrontal neurons encode economic risk and risk prediction error Open